Ankylosing spondylitis

Spondyloarthritis Increases Risk for Dysrhythmias and Aortic Regurgitation

Spondyloarthritis Increases Risk for Dysrhythmias and Aortic Regurgitation

By

The risk for aortic regurgitation and cardiac rhythm abnormalities was evaluated in a nationwide cohort of patients with spondyloarthritis.

Sustained Reduction in axSpA Joint Inflammation With Certolizumab Pegol

Sustained Reduction in axSpA Joint Inflammation With Certolizumab Pegol

By

Decreases in spinal and sacroiliac joint inflammation on MRI were maintained through 204 weeks with certolizumab pegol treatment.

Biologic DMARDs Do Not Reduce Spinal Fracture Risk in Ankylosing Spondylitis

Biologic DMARDs Do Not Reduce Spinal Fracture Risk in Ankylosing Spondylitis

By

Spinal fracture-free survival among patients with AS was not significantly affected by the use of bDMARD therapy.

Use of Secukinumab in Ankylosing Spondylitis: Efficacy and Safety

Use of Secukinumab in Ankylosing Spondylitis: Efficacy and Safety

By

Investigators examined the long-term safety and efficacy of a subcutaneous maintenance dose of secukinumab 150 and 300 mg.

Do Biologic DMARDs Affect Spinal Fracture Risk in Ankylosing Spondylitis?

Do Biologic DMARDs Affect Spinal Fracture Risk in Ankylosing Spondylitis?

By

Male gender and the Charlson Comorbidity Index score contributed significantly to fracture risk in this population.

What Is the Best Site for Assessing Bone Loss in Ankylosing Spondylitis?

What Is the Best Site for Assessing Bone Loss in Ankylosing Spondylitis?

By

Research suggests that the best site to assess bone loss in patients with ankylosing spondylitis is the femoral neck.

Low-Dose CT Scans Detect Bone Proliferation in Ankylosing Spondylitis

Low-Dose CT Scans Detect Bone Proliferation in Ankylosing Spondylitis

By

Low-dose computed tomography detects more bone proliferation in patients with ankylosing spondylitis compared with conventional radiography.

Discontinuation of Biosimilar Infliximab Associated With Subjective Complaints

Discontinuation of Biosimilar Infliximab Associated With Subjective Complaints

By

Transitioning from an originator agent to its biosimilar has the potential to reduce healthcare costs without compromising outcomes.

Etanercept for Spondyloarthritis: Impact on Disease Progression

Etanercept for Spondyloarthritis: Impact on Disease Progression

By

The use of tumor necrosis factor inhibitors to modify structural changes in axial spondyloarthritis may prevent progression to spinal disease.

Endothelial Function Improves With Methotrexate, Anti-TNF Therapy in Inflammatory Arthritis

Endothelial Function Improves With Methotrexate, Anti-TNF Therapy in Inflammatory Arthritis

By

Although the effect of antirheumatic drugs on inflammatory arthritic conditions has not been fully elucidated, treatment with methotrexate and tumor necrosis factor inhibitors has been found to improve endothelial dysfunction in this population.

Online Consultation System Benefits Rheumatic Disease Management

Online Consultation System Benefits Rheumatic Disease Management

The SSDM series of applications is cost-effective for patients of rheumatologists.

Long-Term Safety of Adalimumab in Immune-Related Diseases Analyzed

Long-Term Safety of Adalimumab in Immune-Related Diseases Analyzed

By

Investigators sought to determine the long-term safety of adalimumab use in patients with arthritis and other immune-related diseases.

Predictors of Accelerated Atherosclerosis in Spondyloarthritis Without Overt CVD

Predictors of Accelerated Atherosclerosis in Spondyloarthritis Without Overt CVD

By

Predictors of subclinical accelerated atherosclerosis were examined in a recent study of patients with spondyloarthritis without overt cardiovascular disease.

Minimal Transfer of Certolizumab Pegol to Mature Breast Milk

Minimal Transfer of Certolizumab Pegol to Mature Breast Milk

By

The first lactation study of its kind evaluated whether a biologic drug is transferred into mature breast milk

FDA Approval of Biosimilar Cyltezo for Multiple Indications

FDA Approval of Biosimilar Cyltezo for Multiple Indications

By

Cyltezo subcutaneous injection has been approved by the FDA.

BMI and Treatment Response to TNF Inhibitors in Ankylosing Spondylitis

BMI and Treatment Response to TNF Inhibitors in Ankylosing Spondylitis

By

In patients with AS, those with a BMI in the overweight or obese range had a lower likelihood of clinical improvement with tumor necrosis factor inhibitor therapy.

Nonradiographic Axial Spondyloarthritis May Be Revealed by MRI

Nonradiographic Axial Spondyloarthritis May Be Revealed by MRI

By

A study analyzes whether underlying sacroiliac erosions may be present in patients with nonradiographic axial spondylarthritis who have normal radiographs.

Markers of Radiographic Spinal Progression in Ankylosing Spondylitis

Markers of Radiographic Spinal Progression in Ankylosing Spondylitis

By

Serum leptin and high molecular weight adiponectin have an inverse relationship with radiographic spinal progression in patients with ankylosing spondylitis.

Early Predictors of Poor Long-Term Treatment Response in Spondyloarthritis

Early Predictors of Poor Long-Term Treatment Response in Spondyloarthritis

By

Determining which patients are unlikely to respond to therapy early on may help reduce unnecessary treatment and contain costs.

Anti-TNF-α Rx Improves Sleep in Ankylosing Spondylitis

Anti-TNF-α Rx Improves Sleep in Ankylosing Spondylitis

Patients saw a reduction in PSQI scores, but no change in polysomnography parameters.

Abnormal Chest Radiograph in Uveitis Often Sarcoidosis

Abnormal Chest Radiograph in Uveitis Often Sarcoidosis

Patients with panuveitis more often had biopsy-confirmed sarcoidosis than those with other anatomical locations of uveitis (20% vs 4%).

Systemic Therapy Associated With Improved Visual Acuity in Uveitis

Systemic Therapy Associated With Improved Visual Acuity in Uveitis

At seven-year follow-up, visual acuity was better with systemic therapy than with intravitreous fluocinolone acetonide implants.

MTX + Adalimumab Effective in JIA-Associated Uveitis

MTX + Adalimumab Effective in JIA-Associated Uveitis

In children with active juvenile idiopathic arthritis, the treatment combination controls eye inflammation.

Biosimilar Confidence: Physician-Patient Communication Sets the Tone

Biosimilar Confidence: Physician-Patient Communication Sets the Tone

By

Jonathan Krant, MD, FACP, confronts the issues surrounding biosimilar substitution for biologic treatments.

Etanercept May Increase Risk of Anterior Uveitis in Ankylosing Spondylitis

Etanercept May Increase Risk of Anterior Uveitis in Ankylosing Spondylitis

By

Researchers examined whether different TNF inhibitors were associated with different rates of anterior uveitis in patients with ankylosing spondylitis undergoing treatment with adalimumab, etanercept, or infliximab.

High-dose Steroids Increase Serious Infection Risk in Pregnant Women With Inflammatory Conditions

High-dose Steroids Increase Serious Infection Risk in Pregnant Women With Inflammatory Conditions

By

An observational cohort study of 4961 women with completed pregnancies and a recorded diagnosis of systemic inflammatory conditions.

Minimal Amount of TNF Inhibitor Transfers to Breast Milk, Study Finds

Minimal Amount of TNF Inhibitor Transfers to Breast Milk, Study Finds

By

Study evaluated breast milk samples from 17 lactating mothers diagnosed with rheumatoid arthritis, Crohn's disease, psoriatic arthritis, and axial spondyloarthritis/ankylosing spondylitis.

The Handoff: Your Week in Rheumatology News - 3/3/17

The Handoff: Your Week in Rheumatology News - 3/3/17

By

Connecticut considers rheumatoid arthritis and fibromyalgia for medical marijuana treatment, while Lyme disease-carrying deer ticks continue to invade Michigan. All this and more in this week's edition.

Arthritis and Incident Myocardial Infarction Risk

Arthritis and Incident Myocardial Infarction Risk

By

Research comes from meta-analysis of 25 population-based studies on 5 major forms of arthritis.

NSAIDs Limited For Providing Back Pain Relief

NSAIDs Limited For Providing Back Pain Relief

Only 1 in 6 patients who take NSAIDs for back pain achieved benefits from the therapy.

Sign Up for Free e-newsletters