Ankylosing spondylitis

Online Consultation System Benefits Rheumatic Disease Management

Online Consultation System Benefits Rheumatic Disease Management

The SSDM series of applications is cost-effective for patients of rheumatologists.

Long-Term Safety of Adalimumab in Immune-Related Diseases Analyzed

Long-Term Safety of Adalimumab in Immune-Related Diseases Analyzed

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Investigators sought to determine the long-term safety of adalimumab use in patients with arthritis and other immune-related diseases.

Predictors of Accelerated Atherosclerosis in Spondyloarthritis Without Overt CVD

Predictors of Accelerated Atherosclerosis in Spondyloarthritis Without Overt CVD

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Predictors of subclinical accelerated atherosclerosis were examined in a recent study of patients with spondyloarthritis without overt cardiovascular disease.

Minimal Transfer of Certolizumab Pegol to Mature Breast Milk

Minimal Transfer of Certolizumab Pegol to Mature Breast Milk

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The first lactation study of its kind evaluated whether a biologic drug is transferred into mature breast milk

FDA Approval of Biosimilar Cyltezo for Multiple Indications

FDA Approval of Biosimilar Cyltezo for Multiple Indications

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Cyltezo subcutaneous injection has been approved by the FDA.

BMI and Treatment Response to TNF Inhibitors in Ankylosing Spondylitis

BMI and Treatment Response to TNF Inhibitors in Ankylosing Spondylitis

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In patients with AS, those with a BMI in the overweight or obese range had a lower likelihood of clinical improvement with tumor necrosis factor inhibitor therapy.

Nonradiographic Axial Spondyloarthritis May Be Revealed by MRI

Nonradiographic Axial Spondyloarthritis May Be Revealed by MRI

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A study analyzes whether underlying sacroiliac erosions may be present in patients with nonradiographic axial spondylarthritis who have normal radiographs.

Markers of Radiographic Spinal Progression in Ankylosing Spondylitis

Markers of Radiographic Spinal Progression in Ankylosing Spondylitis

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Serum leptin and high molecular weight adiponectin have an inverse relationship with radiographic spinal progression in patients with ankylosing spondylitis.

Early Predictors of Poor Long-Term Treatment Response in Spondyloarthritis

Early Predictors of Poor Long-Term Treatment Response in Spondyloarthritis

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Determining which patients are unlikely to respond to therapy early on may help reduce unnecessary treatment and contain costs.

Anti-TNF-α Rx Improves Sleep in Ankylosing Spondylitis

Anti-TNF-α Rx Improves Sleep in Ankylosing Spondylitis

Patients saw a reduction in PSQI scores, but no change in polysomnography parameters.

Abnormal Chest Radiograph in Uveitis Often Sarcoidosis

Abnormal Chest Radiograph in Uveitis Often Sarcoidosis

Patients with panuveitis more often had biopsy-confirmed sarcoidosis than those with other anatomical locations of uveitis (20% vs 4%).

Systemic Therapy Associated With Improved Visual Acuity in Uveitis

Systemic Therapy Associated With Improved Visual Acuity in Uveitis

At seven-year follow-up, visual acuity was better with systemic therapy than with intravitreous fluocinolone acetonide implants.

MTX + Adalimumab Effective in JIA-Associated Uveitis

MTX + Adalimumab Effective in JIA-Associated Uveitis

In children with active juvenile idiopathic arthritis, the treatment combination controls eye inflammation.

Biosimilar Confidence: Physician-Patient Communication Sets the Tone

Biosimilar Confidence: Physician-Patient Communication Sets the Tone

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Jonathan Krant, MD, FACP, confronts the issues surrounding biosimilar substitution for biologic treatments.

Etanercept May Increase Risk of Anterior Uveitis in Ankylosing Spondylitis

Etanercept May Increase Risk of Anterior Uveitis in Ankylosing Spondylitis

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Researchers examined whether different TNF inhibitors were associated with different rates of anterior uveitis in patients with ankylosing spondylitis undergoing treatment with adalimumab, etanercept, or infliximab.

High-dose Steroids Increase Serious Infection Risk in Pregnant Women With Inflammatory Conditions

High-dose Steroids Increase Serious Infection Risk in Pregnant Women With Inflammatory Conditions

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An observational cohort study of 4961 women with completed pregnancies and a recorded diagnosis of systemic inflammatory conditions.

Minimal Amount of TNF Inhibitor Transfers to Breast Milk, Study Finds

Minimal Amount of TNF Inhibitor Transfers to Breast Milk, Study Finds

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Study evaluated breast milk samples from 17 lactating mothers diagnosed with rheumatoid arthritis, Crohn's disease, psoriatic arthritis, and axial spondyloarthritis/ankylosing spondylitis.

The Handoff: Your Week in Rheumatology News - 3/3/17

The Handoff: Your Week in Rheumatology News - 3/3/17

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Connecticut considers rheumatoid arthritis and fibromyalgia for medical marijuana treatment, while Lyme disease-carrying deer ticks continue to invade Michigan. All this and more in this week's edition.

Arthritis and Incident Myocardial Infarction Risk

Arthritis and Incident Myocardial Infarction Risk

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Research comes from meta-analysis of 25 population-based studies on 5 major forms of arthritis.

NSAIDs Limited For Providing Back Pain Relief

NSAIDs Limited For Providing Back Pain Relief

Only 1 in 6 patients who take NSAIDs for back pain achieved benefits from the therapy.

ASAS/EULAR Revise Axial Spondyloarthritis Management Recommendations

ASAS/EULAR Revise Axial Spondyloarthritis Management Recommendations

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Collaborative document provides guidance on non-pharmacological and pharmacological management in patients with axial spondyloarthritis.

Risk Factors For NSAID Hypersensitivity Reaction Identified

Risk Factors For NSAID Hypersensitivity Reaction Identified

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A retrospective cohort study found 1 in 5 non-steroidal anti-inflammatory drug (NSAID) adverse drug reactions is a hypersensitivity reaction.

Treatment Efficacy and Clinical Burden in Nonradiographic Axial Spondyloarthritis vs Ankylosing Spondylitis

Treatment Efficacy and Clinical Burden in Nonradiographic Axial Spondyloarthritis vs Ankylosing Spondylitis

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New research compared treatment efficacy by drug class and clinical and humanistic burdens of nr-axSpA with those of AS.

Janssen Seeks FDA Approval for Golimumab in PsA and AS

Janssen Seeks FDA Approval for Golimumab in PsA and AS

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The sBLAs included data from two Phase 3 studies that assessed the safety and efficacy of Simponi Aria 2mg/kg infusion every 8 weeks after two starter doses at Weeks 0 and 4 in adults with active psoriatic arthritis.

Greater AS Partial Remission With IFX + NSAID vs NSAID Monotherapy

Greater AS Partial Remission With IFX + NSAID vs NSAID Monotherapy

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Data from a recent trail show patients with early axial spondyloarthritis (axSpA) had better outcomes when treated with IFX + NPX than with NPX monotherapy.

Cervical BME Correlates With Neck Pain in RA and AS

Cervical BME Correlates With Neck Pain in RA and AS

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Study examines the relationship between bone marrow edema and neck pain in patients with rheumatoid arthritis and ankylosing spondylitis.

Reproducibility of SIJ Classification in Axial SpA

Reproducibility of SIJ Classification in Axial SpA

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The reproducibility of radiographic SIJ classification and potential drivers of disagreement were examined in a SpA inception cohort.

Matching-Adjusted Indirect Comparison of Secukinumab, Adalimumab in AS

Matching-Adjusted Indirect Comparison of Secukinumab, Adalimumab in AS

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Secukinumab treatment was associated with higher ASAS 20 response rates at weeks 16, 24, and 52 and ASAS 40 at weeks 24 and 52 compared with treatment with adalimumab.

Comparative Efficacy of  TNF-α Inhibitors Evaluated in AS

Comparative Efficacy of TNF-α Inhibitors Evaluated in AS

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In this meta-analysis, the researchers found that all TNF-α inhibitors were more effective at treating AS than placebo in direct comparisons, but no differences in efficacy or safety were found between individual TNF-α inhibitors in indirect comparisons.

Updated EULAR Guidelines for RA CVD Risk Management

Updated EULAR Guidelines for RA CVD Risk Management

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The European League Against Rheumatism has released updated management guidelines to address cardiovascular disease risk assessment in patients with rheumatoid arthritis and other inflammatory arthritides.

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