Serum leptin and high molecular weight adiponectin have an inverse relationship with radiographic spinal progression in patients with ankylosing spondylitis.
Determining which patients are unlikely to respond to therapy early on may help reduce unnecessary treatment and contain costs.
Patients saw a reduction in PSQI scores, but no change in polysomnography parameters.
Patients with panuveitis more often had biopsy-confirmed sarcoidosis than those with other anatomical locations of uveitis (20% vs 4%).
At seven-year follow-up, visual acuity was better with systemic therapy than with intravitreous fluocinolone acetonide implants.
In children with active juvenile idiopathic arthritis, the treatment combination controls eye inflammation.
Jonathan Krant, MD, FACP, confronts the issues surrounding biosimilar substitution for biologic treatments.
Researchers examined whether different TNF inhibitors were associated with different rates of anterior uveitis in patients with ankylosing spondylitis undergoing treatment with adalimumab, etanercept, or infliximab.
An observational cohort study of 4961 women with completed pregnancies and a recorded diagnosis of systemic inflammatory conditions.
Study evaluated breast milk samples from 17 lactating mothers diagnosed with rheumatoid arthritis, Crohn's disease, psoriatic arthritis, and axial spondyloarthritis/ankylosing spondylitis.
Connecticut considers rheumatoid arthritis and fibromyalgia for medical marijuana treatment, while Lyme disease-carrying deer ticks continue to invade Michigan. All this and more in this week's edition.
Research comes from meta-analysis of 25 population-based studies on 5 major forms of arthritis.
Only 1 in 6 patients who take NSAIDs for back pain achieved benefits from the therapy.
Collaborative document provides guidance on non-pharmacological and pharmacological management in patients with axial spondyloarthritis.
A retrospective cohort study found 1 in 5 non-steroidal anti-inflammatory drug (NSAID) adverse drug reactions is a hypersensitivity reaction.
Treatment Efficacy and Clinical Burden in Nonradiographic Axial Spondyloarthritis vs Ankylosing SpondylitisJanuary 06, 2017
New research compared treatment efficacy by drug class and clinical and humanistic burdens of nr-axSpA with those of AS.
The sBLAs included data from two Phase 3 studies that assessed the safety and efficacy of Simponi Aria 2mg/kg infusion every 8 weeks after two starter doses at Weeks 0 and 4 in adults with active psoriatic arthritis.
Data from a recent trail show patients with early axial spondyloarthritis (axSpA) had better outcomes when treated with IFX + NPX than with NPX monotherapy.
Study examines the relationship between bone marrow edema and neck pain in patients with rheumatoid arthritis and ankylosing spondylitis.
The reproducibility of radiographic SIJ classification and potential drivers of disagreement were examined in a SpA inception cohort.
Secukinumab treatment was associated with higher ASAS 20 response rates at weeks 16, 24, and 52 and ASAS 40 at weeks 24 and 52 compared with treatment with adalimumab.
In this meta-analysis, the researchers found that all TNF-α inhibitors were more effective at treating AS than placebo in direct comparisons, but no differences in efficacy or safety were found between individual TNF-α inhibitors in indirect comparisons.
The European League Against Rheumatism has released updated management guidelines to address cardiovascular disease risk assessment in patients with rheumatoid arthritis and other inflammatory arthritides.
A biosimilar to adalimumab (adalimumab-atto (Amjevita®, Amgen) has been approved by the US Food and Drug Administration (FDA) to treat moderately to severely active rheumatoid arthritis, active psoriatic arthritis, and active ankylosing spondylitis.
Various studies have examined the link between ankylosing spondylitis (AS) and multiple malignances and autoimmune diseases.
Delayed diagnosis is associated with worse outcomes and poor treatment responses in patients with spondyloarthritis. Andrew Vreede, MD, University of Wisconsin School of Medicine and Public Health, presents a talk about how delays in diagnosing spondyloarthritis can affect access to therapy and long-term outcomes.
Hip-joint lesions, number of affected peripheral arthritis joints, ASO, and CIC were found to be associated with higher rates of uveitis in AS.
Clinical Implications of the Recommended Approval of 2 Biosimilars: Interview With Allan Gibofsky MDJuly 28, 2016
Rheumatology Advisor speaks with Allan Gibofsky, MD, a professor of medicine and public health at Weill Cornell Medical College and an attending rheumatologist at Hospital for Special Surgery in New York, about the recent panel recommendation for FDA approval of biosimilar versions of adalimumab and etanercept.
Patients with AS frequently present with radiographic vertebral fractures, a risk that is more pronounced with older patients, baseline low bone mineral density and those with advanced disease.
Male patients with ankylosing spondylitis had significant decreases in both total and appendicular lean mass, which were both related to higher disease activity and bone loss.
Rheumatology Advisor Articles
- Yoga Equally Effective as PT for Chronic Low Back Pain
- Study finds increased CRP, ESR levels in obese women with RA is related to fat mass rather than disease activity
- Potential Upswing in Tick-borne Infections Predicted
- Lower Risk for Hip Fracture With Alendronate Use Among Older Patients
- Impoved Pain Relief After Total Knee Arthroplasty With SNB Plus FNB
- Chondroitin Sulfate Effective for Knee Osteoarthritis
- Post-Menopause, Early Post-Menopause Associated With Increased Risk of RA
- Yoga Equally Effective as PT for Chronic Low Back Pain
- Markers of Radiographic Spinal Progression in Ankylosing Spondylitis
- Ultrasound More Accurate Diagnosis of Hand Osteoarthritis Than Radiography
- Improved Diagnosis of CVD in Patients With RA: Expert Insights
- Osteoporosis Tx Romosozumab Continues License Application
- Patient Involvement Can Reduce X-Ray Imaging Errors
- Psoriatic Arthritis, Cardiovascular Health Improved With Etanercept Therapy
- Is it Worth Evaluating Accountable Care Organization Cost Savings?