Bone Mineral Density

Updated UK Clinical Guidelines for Osteoporosis Emphasize Risk Assessment and Prevention

Updated UK Clinical Guidelines for Osteoporosis Emphasize Risk Assessment and Prevention

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The UK National Osteoporosis Guideline Group released updated guidelines for the prevention of fragility fracture in postmenopausal women and in men aged 50 years or older.

Low Hip BMD Associated With Higher HF Risk in Certain Patient Subgroups

Low Hip BMD Associated With Higher HF Risk in Certain Patient Subgroups

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Total hip BMD was associated with heart failure risk in black and non-black men, with an interaction by race.

DXA Not Useful for Workup of Vertebral Compression Deformities With Normal BMD

DXA Not Useful for Workup of Vertebral Compression Deformities With Normal BMD

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Researchers compared the efficacy of dual-energy x-ray absorptiometry with lateral x-ray in assessing vertebral fractures.

The Handoff: Your Week in Rheumatology News - 4/14/17

The Handoff: Your Week in Rheumatology News - 4/14/17

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This week, a phase III trial for investigational drug voclosporin for lupus nephritis treatment was approved, prolonged insomnia may lead to less robust bone formation — causing osteoporosis and bone fractures — and researchers found that women who drink a moderate amount of alcohol daily have a reduced risk of developing systemic lupus erythmatosus.

Postmenopause Osteoporosis Drug Denosumab Demonstrates Long-term Safety

Postmenopause Osteoporosis Drug Denosumab Demonstrates Long-term Safety

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Three-year fracture study examines the effects of osteoporosis drug denosumab on fractures, bone mineral density, and bone turnover markers in postmenopausal women with osteoporosis.

Anti-fracture Therapy Prevents Bone Loss in Women After Critical Illness

Anti-fracture Therapy Prevents Bone Loss in Women After Critical Illness

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Prospective observational cohort study examines association between post-ICU administration of anti-fracture therapy or glucocorticoids and longitudinal changes in bone mineral density.

Testosterone Treatment Increases Bone Mineral Density and Strength in Older Men

Testosterone Treatment Increases Bone Mineral Density and Strength in Older Men

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Testosterone treatments help improve volumetric bone mineral density and bone strength in elderly men with low testosterone.

Utility of Trabecular Bone Score in Assessing Bone Quality in Type 2 Diabetes

Utility of Trabecular Bone Score in Assessing Bone Quality in Type 2 Diabetes

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The trabecular bone score may provides an acute, albeit indirect, measurement of bone quality in patients with type 2 diabetes.

Predicting Vertebral Fracture Risk After Bisphosphonate Drug Holiday

Predicting Vertebral Fracture Risk After Bisphosphonate Drug Holiday

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Study examines the predictive value for vertebral fractures of bone mineral density and bone turnover markers after a 5-year drug holiday.

Bone Metabolism Risks Associated With Tenofovir for Hepatitis B Infection

Bone Metabolism Risks Associated With Tenofovir for Hepatitis B Infection

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Long-term tenofovir treatment for hepatitis B infection is linked with abnormal phosphorus metabolism in a recent study.

VIDEO: Updated Clinical Trial Results for Abaloparatide

VIDEO: Updated Clinical Trial Results for Abaloparatide

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Lorraine Fitzpatrick, MD, discusses updated results from the ACTIVE phase 3 clinical trial.

Postmenopausal Hormone Therapy Improves Bone Structure

Postmenopausal Hormone Therapy Improves Bone Structure

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Higher Trabecular Bone Scores were found in postmenopausal women taking hormone replacement therapy compared with women who had never used hormone therapy.

Protectective Effects of DMARDs on Bone Loss

Protectective Effects of DMARDs on Bone Loss

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DMARDs have been shown to be effective in halting progressive bone loss in rheumatoid arthritis.

Stimulant Use Linked to Low Lumbar, Femur BMD in Adolescents

Stimulant Use Linked to Low Lumbar, Femur BMD in Adolescents

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Pediatric and adolescent patients who used stimulants to treat ADHD were found to have low bone density and bone mineral content.

Call to Action Issued to Address Ongoing Osteoporosis Treatment Crisis

Call to Action Issued to Address Ongoing Osteoporosis Treatment Crisis

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Kenneth Saag, MD, president of the National Osteoporosis Foundation (NOF), co-chair of the National Bone Health Alliance, and Rheumatology Advisor advisory board member, reports on the recent changes that have led to the current state of osteoporosis treatment in the US.

Association Between Time Spent Sitting and BMD Investigated

Association Between Time Spent Sitting and BMD Investigated

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Findings showing that sedentary time was not significantly linked to bone mineral density weaken the previous association between physical activity and bone mineral density.

Fracture Risk With ARBs, CCBs, ACE Inhibitors Compared

Fracture Risk With ARBs, CCBs, ACE Inhibitors Compared

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The use of ARBs was associated with lower incidence of non-vertebral fractures than ACE inhibitors or CCBs.

Denosumab vs Risendronate for GC-Induced Osteoporosis

Denosumab vs Risendronate for GC-Induced Osteoporosis

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Denosumab treatment led to significant increases in BMD at the lumbar spine and total hip at 12 months as compared to risedronate, both in patients receiving continuing glucocorticoid therapy and those just starting glucocorticoid therapy.

Bone Turnover Markers Used to Create New Bone Balance Index

Bone Turnover Markers Used to Create New Bone Balance Index

To better predict bone loss during the menopausal transition, researchers created the bone balance index using bone turnover markers to measure net bone formation.

Are Changes in Serial DXA Scans Reliable Indicators of Fracture Risk?

Are Changes in Serial DXA Scans Reliable Indicators of Fracture Risk?

Interval changes in bone mineral density (BMD) detected by dual-energy x-ray absorptiometry (DXA) are associated with fracture risk in women starting osteoporosis treatment

OCP Less Effective Than HRT at Increasing Lumbar BMD in POF

OCP Less Effective Than HRT at Increasing Lumbar BMD in POF

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In women with premature ovarian failure, hormone replacement therapy was associated with greater increases in bone mineral density.

Lower Peak Bone Mass, Osteogenic Precursors With HIV T-Cell Activation

Lower Peak Bone Mass, Osteogenic Precursors With HIV T-Cell Activation

Lower BMD and abnormal trabecular bone microstructure with reduced bone strength was found in men with early HIV infection

Automated Messages in EHR Increased DXA Screening, Osteoporosis Rx

Automated Messages in EHR Increased DXA Screening, Osteoporosis Rx

After introducing the electronic health record pop-up messages, the rate of DXA prescriptions increased.

Advanced Glycation Endproducts May Decrease Bone Material Strength Indices in T2D

Advanced Glycation Endproducts May Decrease Bone Material Strength Indices in T2D

Advanced glycation endproducts were linked to reduced bone material properties in postmenopausal women with type 2 diabetes.

Can High-Dose Folic Acid During Lactation Reverse SSRI-Induced Bone Resorption?

Can High-Dose Folic Acid During Lactation Reverse SSRI-Induced Bone Resorption?

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High doses of folic acid appeared to mitigate the effects of bone loss.

Phase 3 Trial Results for Investigational Sclerostin Inhibitor

Phase 3 Trial Results for Investigational Sclerostin Inhibitor

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Amgen and UCB announced results from a phase 3 study evaluating romosozumab for the treatment of osteoporosis in men.

Changes in Bisphosphonate Use Resulting From FDA Safety Anouncements

Changes in Bisphosphonate Use Resulting From FDA Safety Anouncements

The usage of bisphosphonates decreased as a result of safety announcements issued by the United States Food and Drug Administration (FDA) regarding potential adverse effects of bisphosphonates after hip fracture.

Updated Recommendations for Development of Peak Bone Mass

Updated Recommendations for Development of Peak Bone Mass

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Following a systematic evidence review, the National Osteoporosis Foundation (NOF) has developed practice guidelines based on the graded strength of current evidence.

Bone Modulation Strategies for the Prevention of Osteoporosis-Associated Fractures

Bone Modulation Strategies for the Prevention of Osteoporosis-Associated Fractures

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Nearly half of all fractures in women over age 50 are associated with osteoporosis.

Retraction Requested for Study of Nitroglycerin in Bone Density

Retraction Requested for Study of Nitroglycerin in Bone Density

Investigation found that the lead author fabricated data used to support the finding that nitroglycerin improved bone density in older women.

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