Clinical Trials

Evolution of Informed Consent in Medical Research: An Expert Interview

Evolution of Informed Consent in Medical Research: An Expert Interview

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New approaches to informed consent using technology advances are changing the way participants are informed and how researchers obtain their permission.

WHO, NIH, FDA Concerned Negative Data Lacking in Clinical Trial Results

WHO, NIH, FDA Concerned Negative Data Lacking in Clinical Trial Results

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Researchers find that 29% of data from trials went unreported from 1999 to 2009.

BLA Submitted for RA Investigational IL-6 Monoclonal Antibody

BLA Submitted for RA Investigational IL-6 Monoclonal Antibody

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A Biologics License Application (BLA) for sirukumab, a human monoclonal IgG1 kappa antibody targeting IL-6, was submitted by Janssen Biotech to the Food and Drug Administration (FDA) for the treatment of adults with moderately to severely active rheumatoid arthritis (RA).

Efficacy of IL-6 Inhibition in csDMARD-Inadequate Responders With PsA

Efficacy of IL-6 Inhibition in csDMARD-Inadequate Responders With PsA

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In the first randomized controlled study evaluating the efficacy of targeted IL-6 inhibition in PsA,researchers found that clazakizumab 100 mg significantly reduced PsA disease severity as quantified by ACR20 scores at week 16 post-randomization compared with placebo.

Clinical Data Sharing Rates From Industry-Funded Trials Low

Clinical Data Sharing Rates From Industry-Funded Trials Low

The proportion of clinical trials registered at ClinicalTrials.gov and sponsored by 4 pharmaceutical companies who reported sharing of data was examined

Biosimilars: Identifying Knowledge Gaps and Patient Perceptions

Biosimilars: Identifying Knowledge Gaps and Patient Perceptions

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Gaps in knowledge regarding biosimilars were recently identified by researchers between patients receiving these drugs, their caregivers, and the general population.

Lack of Older Adults Included in Rheumatoid Arthritis Clinical Trials May Be Hampering Care

Lack of Older Adults Included in Rheumatoid Arthritis Clinical Trials May Be Hampering Care

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A lack of clinical evidence is one of many significant barriers when it comes to providing optimal care for elderly-onset rheumatoid arthritis.

Minority of Physicians Consider Clinical Trials Early in Treatment Course

Minority of Physicians Consider Clinical Trials Early in Treatment Course

Failing to consider clinical trials in disease management can represent a significant missed opportunity on the part of both clinicians and patients.

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