Gout

Uric Acid Predicts AKI Risk After Cardiac Surgery

Uric Acid Predicts AKI Risk After Cardiac Surgery

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Serum uric acid levels above the median prior to cardiac surgery is independently associated with 5.5-fold increased odds of postoperative acute kidney injury.

Gout Increases Atrial Fibrillation Risk in the Elderly

Gout Increases Atrial Fibrillation Risk in the Elderly

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A study of Medicare patients found that atrial fibrillation was nearly twice as likely to develop in those with vs without gout.

Patients With Early-Onset Gout Develop Earlier Metabolic Comorbidities, Severe Joint Involvement

Patients With Early-Onset Gout Develop Earlier Metabolic Comorbidities, Severe Joint Involvement

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Patients with early-onset gout experience more severe acute joint involvement and earlier metabolic comorbidities than those with common gout.

Gout Associated With Increased Risk of Developing Erectile Dysfunction

Gout Associated With Increased Risk of Developing Erectile Dysfunction

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Data show that gout is associated with an increased risk of developing erectile dysfunction.

Hospitalization Increases Risk for Acute Gout Flares

Hospitalization Increases Risk for Acute Gout Flares

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Researchers sought to assess the risk for in-hospital gout flares in patients with gout.

Both High and  Low Uric Acid Levels Tied to Higher Mortality

Both High and Low Uric Acid Levels Tied to Higher Mortality

Both high and low uric acid levels are associated with an increased risk for mortality.

Emergency Department Visits for Gout Rise Dramatically

Emergency Department Visits for Gout Rise Dramatically

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A study documents a 27% increase in visits to emergency departments for a primary diagnosis of acute gout from 2006 to 2014.

Genetically High Plasma Vitamin C Not Associated With Risk for Hyperuricemia

Genetically High Plasma Vitamin C Not Associated With Risk for Hyperuricemia

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Data suggest that vitamin C supplementation should not be recommended to lower plasma urate.

Medication Adherence Low in Patients With Gout Initiating Allopurinol Therapy

Medication Adherence Low in Patients With Gout Initiating Allopurinol Therapy

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Medication adherence also remained low in patients who reinitiate treatment after a gap in therapy.

Similar Cardiovascular Risk Reported in Patients Initiating Febuxostat vs Allopurinol

Similar Cardiovascular Risk Reported in Patients Initiating Febuxostat vs Allopurinol

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Recent data showed no difference in the risk for myocardial infarction, stroke, new-onset heart failure, coronary revascularization, or all-cause mortality between patients initiating febuxostat compared with allopurinol.

Febuxostat vs Allopurinol in Gout: Assessing the Implications of CV Safety

Febuxostat vs Allopurinol in Gout: Assessing the Implications of CV Safety

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The FDA recently issued a public safety alert in response to the results of CARES trial, which showed increased CV and all-cause mortality in patients with gout and established CVD who were treated with febuxostat therapy.

Monosodium Urate Crystal Deposits Common in Asymptomatic Sons of Individuals With Gout

Monosodium Urate Crystal Deposits Common in Asymptomatic Sons of Individuals With Gout

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Asymptomatic sons of people with gout frequently have hyperuricemia and monosodium urate crystal deposits.

DECT Superior to Ultrasound for Identification of Gouty Knee Arthritis

DECT Superior to Ultrasound for Identification of Gouty Knee Arthritis

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Dual-energy computed tomography was superior to ultrasound for diagnosing suspected gouty knee arthritis.

Allopurinol Medication Adherence Increased With Daily Text Message Reminders

Allopurinol Medication Adherence Increased With Daily Text Message Reminders

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Mobile phone text reminders could be an important tool to enhance medication adherence in people with gout.

Gout, Urate-Lowering Therapy Not Associated With Risk for Fragility Fracture

Gout, Urate-Lowering Therapy Not Associated With Risk for Fragility Fracture

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The use of urate-lowering therapy in patients with gout had neither beneficial nor adverse effects on long-term fracture risk.

Pegloticase Retreatment Effective for Gout After Gap in Therapy

Pegloticase Retreatment Effective for Gout After Gap in Therapy

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The study authors retrospectively analyzed the charts of 4 chronic gout patients from a practice-based rheumatology clinic.

Incident Gout Risk, Serum Urate, and Comorbidities: What Are the Links?

Incident Gout Risk, Serum Urate, and Comorbidities: What Are the Links?

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Ethnicity and hypertension have an association with incident gout that is not fully explained by differences in serum urate.

Crystal-Proven Gout, Gout Severity Factors Linked to Cardiovascular Disease

Crystal-Proven Gout, Gout Severity Factors Linked to Cardiovascular Disease

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Investigators sought to examine the prevalence of CVD in patients with crystal-proven gout compared with control patients with arthritis.

Racial Variations Linked to Risk for Allopurinol-Associated Adverse Reactions

Racial Variations Linked to Risk for Allopurinol-Associated Adverse Reactions

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Researchers found that the overall risk for hospitalization due to allopurinol-associated severe cutaneous adverse reactions is rare.

Examining Unmet Needs of Joint Disease Associated With Calcium Pyrophosphate Crystal Deposition

Examining Unmet Needs of Joint Disease Associated With Calcium Pyrophosphate Crystal Deposition

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Addressing the challenges associated with clinical management of calcium pyrophosphate crystal deposition must start with understanding the unmet needs of associated joint damage and establishing a clearly defined strategy to address these needs.

Corticosteroids May Be an Effective Alternative to NSAIDs in Acute Gout Pain

Corticosteroids May Be an Effective Alternative to NSAIDs in Acute Gout Pain

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Corticosteroids appear to be a reasonable alternative to NSAIDs for the treatment of acute pain as a result of gout.

Fenofibrate Decreases Plasma Uric Acid Concentration, Gout Events in T2D

Fenofibrate Decreases Plasma Uric Acid Concentration, Gout Events in T2D

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Fenofibrate may be a valuable adjunct therapy in type 2 diabetes to reduce the burden of gout.

Allopurinol Dose Escalation May Not Improve Survival in Patients With Gout

Allopurinol Dose Escalation May Not Improve Survival in Patients With Gout

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Investigators sought to determine whether allopurinol dose escalation is associated with all-cause mortality.

Ultrasound Reliably Identifies Calcium Pyrophosphate Deposition Disease

Ultrasound Reliably Identifies Calcium Pyrophosphate Deposition Disease

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Ultrasound is a reliable diagnostic tool for identifying calcium pyrophosphate deposition disease.

Febuxostat vs Allopurinol Evaluated in Patients With Gout, CVD

Febuxostat vs Allopurinol Evaluated in Patients With Gout, CVD

Febuxostat is noninferior to allopurinol for rates of adverse CV events but is associated with higher all-cause and CV mortality in patients with gout and CVD.

Development of Clinically Evident Gout: A Closer Look at Elevated Serum Urate Levels

Development of Clinically Evident Gout: A Closer Look at Elevated Serum Urate Levels

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Serum urate level is a strong predictor of incident gout, but only about half of patients with hyperuricemia develop clinically evident gout.

Ocular Complications of Gout: The Spectrum of Urate Crystal Deposition

Ocular Complications of Gout: The Spectrum of Urate Crystal Deposition

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A patient with a history of uncontrolled gout presents with highly refractile, crystal-like macular lesions.

Elevated Serum Uric Acid Levels May Increase Risk for Dementia in Older Adults

Elevated Serum Uric Acid Levels May Increase Risk for Dementia in Older Adults

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Risk for dementia may be increased with high serum uric acid levels in elderly individuals.

Examining the Connection Between Gout and Metabolic Syndrome

Examining the Connection Between Gout and Metabolic Syndrome

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Assessing the relationship between gout and the metabolic syndrome may provide insight into the management of both conditions.

Higher Monosodium Urate Crystal Depositions With Greater Disease Severity in Allopurinol-Treated Gout

Higher Monosodium Urate Crystal Depositions With Greater Disease Severity in Allopurinol-Treated Gout

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In patients with gout who are treated with allopurinol, monosodium urate crystal depositions are higher with evidence of greater disease severity.

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