Gout

Higher Monosodium Urate Crystal Depositions With Greater Disease Severity in Allopurinol-Treated Gout

Higher Monosodium Urate Crystal Depositions With Greater Disease Severity in Allopurinol-Treated Gout

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In patients with gout who are treated with allopurinol, monosodium urate crystal depositions are higher with evidence of greater disease severity.

Febuxostat Lowers Blood Pressure in Patients With Hyperuricemia and Hypertension

Febuxostat Lowers Blood Pressure in Patients With Hyperuricemia and Hypertension

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Febuxostat may lower blood pressure in patients with hyperuricemia, hypertension, and normal renal function.

Allopurinol Use May Lower Risk for Peripheral Arterial Disease

Allopurinol Use May Lower Risk for Peripheral Arterial Disease

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New allopurinol use was associated with a reduced risk of incident peripheral arterial disease.

Metoprolol Elevates Serum Uric Acid and Gout Risk in African Americans

Metoprolol Elevates Serum Uric Acid and Gout Risk in African Americans

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As the risk of developing gout is high in patients with hypertension, management of serum uric acid levels may improve patient outcomes.

Gout Flares Reduced by Febuxostat Increase Plus Low-Dose Colchicine

Gout Flares Reduced by Febuxostat Increase Plus Low-Dose Colchicine

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A stepwise dose increase in febuxostat plus low-dose colchicine prophylaxis was effective in the reduction of gout flares compared with febuxostat alone.

Gout Increases Incident Stroke Risk by the Same Magnitude as Diabetes

Gout Increases Incident Stroke Risk by the Same Magnitude as Diabetes

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A recent study assessed whether gout is a cardiovascular risk equivalent for stroke and myocardial infarction, similar to diabetes.

FDA Alert: Febuxostat May Increase Risk of Heart-Related Adverse Events, Death

FDA Alert: Febuxostat May Increase Risk of Heart-Related Adverse Events, Death

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Gout medication febuxostat (Uloric) was associated with an increased risk of heart-related death and death from all causes.

Online Consultation System Benefits Rheumatic Disease Management

Online Consultation System Benefits Rheumatic Disease Management

The SSDM series of applications is cost-effective for patients of rheumatologists.

Treatment Options to Explore When Serum Uric Acid Targets Are Not Attained

Treatment Options to Explore When Serum Uric Acid Targets Are Not Attained

Machelle Manuel, PhD, discusses further gout treatment options to consider when target serum urate levels are not attained.

High-Dose Lesinurad Deemed Unsuitable as Monotherapy for Gout

High-Dose Lesinurad Deemed Unsuitable as Monotherapy for Gout

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Despite rapidly lowering serum uric acid levels, lesinurad cannot be recommended alone at 400 mg per day, due to substantial adverse events.

Gout Flares May Be Reduced With Febuxostat

Gout Flares May Be Reduced With Febuxostat

A recent clinical trial has shown promising results that the drug febuxostat is effective at reducing gout flares in adults with early gout.

FDA Approves Duzallo for Hyperuricemia Associated With Uncontrolled Gout

FDA Approves Duzallo for Hyperuricemia Associated With Uncontrolled Gout

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The US FDA has approved a new fixed-dose and dual-mechanism treatment option for uncontrolled gout.

Lesinurad, Febuxostat Combination Treatment Improves Tophaceous Gout Symptoms

Lesinurad, Febuxostat Combination Treatment Improves Tophaceous Gout Symptoms

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Patients with tophaceous gout undergoing combination therapy with lesinurad and febuxostat showed a greater degree of symptom resolution than with febuxostat monotherapy.

Recall: Gout Pills Found in Platelet Inhibitor Sample Bottle

Recall: Gout Pills Found in Platelet Inhibitor Sample Bottle

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Accidental patient dosing with Zurampic can potentially cause adverse renal effects such as acute renal failure; this is more common if Zurampic is given alone without a xanthine oxidase inhibitor.

Analysis of Factors Improving Rx Adherence in Patients with Gout

Analysis of Factors Improving Rx Adherence in Patients with Gout

Belief about medicines, presence of comorbidity, and being married positively influence adherence to medication.

DASH Diet May Help Lower Occurrence of Gout

DASH Diet May Help Lower Occurrence of Gout

Following the diet may be a good option for patients who prefer to avoid medication.

Low Serum Uric Acid Levels Significantly Reduce Gout Risk

Low Serum Uric Acid Levels Significantly Reduce Gout Risk

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Reduced levels of serum uric acid are associated with markedly fewer new-onset gout and gout flares.

Age, Tophi Linked to Mortality in Gout

Age, Tophi Linked to Mortality in Gout

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The presence of tophi at baseline was associated with an almost 3-fold increased risk for death from all causes.

Systematic Review Analyzes Antihypertensive Effects of Hyperuricemia Pharmacotherapy

Systematic Review Analyzes Antihypertensive Effects of Hyperuricemia Pharmacotherapy

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There was low quality evidence from three trials indicating no reduction in systolic (-6.2mmHg, 95% CI: -12.8 to 0.5) or diastolic (-3.9mmHg, 95% CI: -9.2 to 1.4) 24-hour ambulatory BP with uric acid lowering drugs vs. placebo.

Clinician Round Table: The Role of Diet in Gout Management

Clinician Round Table: The Role of Diet in Gout Management

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A panel of clinician experts discusses the pivotal role of diet in the management of chronic gout.

Allopurinol Use In Concomitant Gout and Diabetes Lowers Cardiovascular Event Risk

Allopurinol Use In Concomitant Gout and Diabetes Lowers Cardiovascular Event Risk

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Study analyzes insurance claims data to examine the relationship between allopurinol use in patients with both gout and diabetes and its effect on cardiovascular event risk.

Ultrasound Finds Distinct Ankle Pathologies In Rheumatic Diseases

Ultrasound Finds Distinct Ankle Pathologies In Rheumatic Diseases

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Ultrasonography detects different ankle pathologies in various inflammatory rheumatic diseases.

Arthritis and Incident Myocardial Infarction Risk

Arthritis and Incident Myocardial Infarction Risk

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Research comes from meta-analysis of 25 population-based studies on 5 major forms of arthritis.

The Handoff: Your Week in Rheumatology News - 2/17/17

The Handoff: Your Week in Rheumatology News - 2/17/17

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Clinical management recommendations for juvenile dermatomyositis, updated guidelines for low back pain treatment, and more of this week's news.

Do Risk Prediction Tools Underestimate Incidence of Carotid Plaque in Gout?

Do Risk Prediction Tools Underestimate Incidence of Carotid Plaque in Gout?

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Study evaluated cardiovascular risk in patients with a new diagnosis of gout using risk prediction tools and carotid ultrasound.

Gout Associated With Increased Hip Fracture Risk in Women

Gout Associated With Increased Hip Fracture Risk in Women

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Prospective study examines women with a history of gout and risk of hip and wrist fractures.

Fixed-Dose Combination Drug for Hyperuricemia Accepted for Review by FDA

Fixed-Dose Combination Drug for Hyperuricemia Accepted for Review by FDA

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The Food and Drug Administration (FDA) has accepted for review the New Drug Application (NDA) for Duzallo (lesinurad/allopurinol fixed-dose combination; Ironwood) for the treatment of hyperuricemia in patients with uncontrolled gout.

Increased Attention on Gout  Favors Patients in Need

Increased Attention on Gout Favors Patients in Need

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Machelle Manuel, PhD, vice president of medical scientific affairs, at Ironwood Pharmaceuticals discusses new hyperuricemia treatment options.

Sound Bite: Clinician Researcher Discusses Newly Available Lesinurad Data

Sound Bite: Clinician Researcher Discusses Newly Available Lesinurad Data

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Puja Paul Khanna, MD, MPH, sat down with Rheumatology Advisor to discuss the safety profile of lesinurad.

Should Febuxostat Be Used in Patients With Prior Skin Reaction to Allopurinol?

Should Febuxostat Be Used in Patients With Prior Skin Reaction to Allopurinol?

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A study found that 1 in 5 patients with history of prior skin reaction to allopurinol also developed similar reaction after febuxostat treatment.

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