Gout

Gout Associated With Worse Outcomes in Obstructive Coronary Artery Disease

Gout Associated With Worse Outcomes in Obstructive Coronary Artery Disease

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A history of gout was associated with worse outcomes in patients with obstructive coronary artery disease.

Gout Associated With Psoriatic Arthritis, Psoriasis in Adults

Gout Associated With Psoriatic Arthritis, Psoriasis in Adults

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Data show an increased prevalence of psoriasis in patients with gout compared with patients without gout.

Gout Increases Risk for Chronic Kidney Disease

Gout Increases Risk for Chronic Kidney Disease

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Gout may be a risk factor for the development of CKD stage ≥3.

Allopurinol Linked to Reduced Risk for CKD Stage ≥3 in Gout

Allopurinol Linked to Reduced Risk for CKD Stage ≥3 in Gout

For patients with gout, allopurinol is associated with a reduced risk for developing chronic kidney disease stage ≥3.

Panel Issues Consensus Statement on Management of Gouty Arthritis of the Foot and Ankle

Panel Issues Consensus Statement on Management of Gouty Arthritis of the Foot and Ankle

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An expert panel evaluated 23 separate statements related to the etiology, diagnosis, and treatment of gout.

High Gout Burden Found Among Solid Organ Transplant Recipients

High Gout Burden Found Among Solid Organ Transplant Recipients

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Study reveals an 11% prevalence of active gout among solid organ transplant recipients overall and a 13% prevalence among kidney transplant recipients.

Ultrasound Reveals Decreased Urate Deposits After Urate-Lowering Therapy in Gout

Ultrasound Reveals Decreased Urate Deposits After Urate-Lowering Therapy in Gout

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Ultrasound can show decreased urate deposition after urate lowering therapy.

Failure to Meet Optimal Urate Levels Increases Mortality Risk in Gout

Failure to Meet Optimal Urate Levels Increases Mortality Risk in Gout

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Patients with gout who did not reach a serum uric acid level below 6 mg/dL had a 2.4-fold increased risk for death.

Gout Linked to Higher Risk for Incident Parkinson Disease in Older Adults

Gout Linked to Higher Risk for Incident Parkinson Disease in Older Adults

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Gout may be associated with a higher risk for incident PD in older adults.

Gout Outcomes Improved With Nurse-Led Care

Gout Outcomes Improved With Nurse-Led Care

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In a British study, nurse-led care emphasizing patient education and engagement significantly improved the proportion of gout sufferers who achieved target serum urate levels.

Increased Levels of Plasma Leukotriene B<sub>4</sub> Found in Acute Gout

Increased Levels of Plasma Leukotriene B4 Found in Acute Gout

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The plasma level of leukotriene B4 was increased in patients with acute gout.

Diet Less Important Than Genes for High Serum Urate Levels

Diet Less Important Than Genes for High Serum Urate Levels

Diet explains little of the variation in serum urate levels in the general population, while genetic factors make a greater contribution.

Ultrasound Can Reveal Renal Medulla Urate Deposits in Tophaceous Gout

Ultrasound Can Reveal Renal Medulla Urate Deposits in Tophaceous Gout

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Ultrasound examination may be used to detect crystal deposition in the renal medulla in patients with tophaceous gout.

Examining Referral Patterns for DECT in Diagnosis, Management of Gout

Examining Referral Patterns for DECT in Diagnosis, Management of Gout

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Researchers examined the use of dual-energy computed tomography gout imaging in clinical practice from 2007 to 2016.

Monosodium Urate Measured With DECT Predicts Risk for Flare in Gout

Monosodium Urate Measured With DECT Predicts Risk for Flare in Gout

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The extent of monosodium urate burden measured with dual-energy computed tomography can predict the risk for disease flares in patients with gout.

Routine Knee, Metatarsophalangeal Joint Examination May Improve Gout Diagnosis

Routine Knee, Metatarsophalangeal Joint Examination May Improve Gout Diagnosis

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Researchers evaluated the distribution of ultrasound features of lower-limb joints and the risk factors of tophus in patients with gout.

Clinical Gout-Related Benefits Not Demonstrated With Lesinurad Combination Therapy

Clinical Gout-Related Benefits Not Demonstrated With Lesinurad Combination Therapy

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Although a combination of lesinurad 200 mg and xanthine oxidase inhibitor therapy was effective and well-tolerated among patients with gout, clinical gout-related benefits were not improved.

Patients With Obstructive Sleep Apnea Have Increased Risk for Gout

Patients With Obstructive Sleep Apnea Have Increased Risk for Gout

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People with obstructive sleep apnea continued to be at higher risk of developing gout after the first year of obstructive sleep apnea diagnosis.

Gout Attack Risk Lowered With Interleukin-1ß Blockade

Gout Attack Risk Lowered With Interleukin-1ß Blockade

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Inhibition of IL-1ß with canakinumab significantly decreased gout attack risk at all baseline serum uric acid (SUA) levels and without changing SUA levels.

Limited Evidence for Teratogenicity of Allopurinol Use During Pregnancy

Limited Evidence for Teratogenicity of Allopurinol Use During Pregnancy

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Researchers found insufficient evidence of teratogenicity for allopurinol taken prior to or during pregnancy.

Managing Gout in Patients Undergoing Bariatric Surgery

Managing Gout in Patients Undergoing Bariatric Surgery

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Although bariatric surgery is the most effective treatment strategy for severe obesity, there is a dearth of research regarding the effects of this procedure on patients with gout.

Patients With Gout Have Lower Prevalence of Colorectal Cancer

Patients With Gout Have Lower Prevalence of Colorectal Cancer

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The 10-year prevalence of colonoscopy-documented colorectal cancer was 0.8% among gout patients vs 3.7% among osteoarthritis patients.

Gout Linked to Increased Risk for Hearing Loss in the Elderly

Gout Linked to Increased Risk for Hearing Loss in the Elderly

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Gout was associated with a higher risk of developing hearing loss in older adults.

Urate Levels Predict Long-Term Gout Risk

Urate Levels Predict Long-Term Gout Risk

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In a large Swedish study of middle-aged individuals, increments in baseline serum urate levels were associated with progressively increased risks of gout over a mean 28 years of follow-up.

Long-Term Safety Data Raise No New Concerns for Approved Lesinurad Dose in Gout

Long-Term Safety Data Raise No New Concerns for Approved Lesinurad Dose in Gout

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Treating patients with gout with lesinurad 200 mg and xanthine oxidase inhibitors for 24 months revealed no new safety concerns.

Inadequate Response to Allopurinol Dose Escalation Associated With Younger Age, Low Adherence

Inadequate Response to Allopurinol Dose Escalation Associated With Younger Age, Low Adherence

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A minority of people with gout never reach target serum urate levels when allopurinol dose is increased in a treat-to-target manner.

Elevated Ferritin Levels Associated With Risk for Gout, Flare Frequency

Elevated Ferritin Levels Associated With Risk for Gout, Flare Frequency

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Increased ferritin levels were associated with gout and flare frequency.

Obesity Associated With Increased Risk for Gout, Higher Serum Urate Concentrations

Obesity Associated With Increased Risk for Gout, Higher Serum Urate Concentrations

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Overall obesity is associated with an increased risk for gout and with higher serum urate concentrations.

Urate-Lowering Therapy May Not Mediate Arthroplasty Risk in Gout

Urate-Lowering Therapy May Not Mediate Arthroplasty Risk in Gout

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Patients with gout have an increased risk for total joint replacement, which may not be reduced by urate-lowering treatment.

Extended-Release vs Immediate-Release Febuxostat in Gout With Renal Impairment

Extended-Release vs Immediate-Release Febuxostat in Gout With Renal Impairment

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Researchers assessed the efficacy and safety of febuxostat extended release and immediate release in patients with gout and normal or impaired renal function.

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