Gout

Gout, Urate-Lowering Therapy Not Associated With Risk for Fragility Fracture

Gout, Urate-Lowering Therapy Not Associated With Risk for Fragility Fracture

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The use of urate-lowering therapy in patients with gout had neither beneficial nor adverse effects on long-term fracture risk.

Pegloticase Retreatment Effective for Gout After Gap in Therapy

Pegloticase Retreatment Effective for Gout After Gap in Therapy

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The study authors retrospectively analyzed the charts of 4 chronic gout patients from a practice-based rheumatology clinic.

Incident Gout Risk, Serum Urate, and Comorbidities: What Are the Links?

Incident Gout Risk, Serum Urate, and Comorbidities: What Are the Links?

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Ethnicity and hypertension have an association with incident gout that is not fully explained by differences in serum urate.

Crystal-Proven Gout, Gout Severity Factors Linked to Cardiovascular Disease

Crystal-Proven Gout, Gout Severity Factors Linked to Cardiovascular Disease

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Investigators sought to examine the prevalence of CVD in patients with crystal-proven gout compared with control patients with arthritis.

Racial Variations Linked to Risk for Allopurinol-Associated Adverse Reactions

Racial Variations Linked to Risk for Allopurinol-Associated Adverse Reactions

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Researchers found that the overall risk for hospitalization due to allopurinol-associated severe cutaneous adverse reactions is rare.

Examining Unmet Needs of Joint Disease Associated With Calcium Pyrophosphate Crystal Deposition

Examining Unmet Needs of Joint Disease Associated With Calcium Pyrophosphate Crystal Deposition

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Addressing the challenges associated with clinical management of calcium pyrophosphate crystal deposition must start with understanding the unmet needs of associated joint damage and establishing a clearly defined strategy to address these needs.

Corticosteroids May Be an Effective Alternative to NSAIDs in Acute Gout Pain

Corticosteroids May Be an Effective Alternative to NSAIDs in Acute Gout Pain

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Corticosteroids appear to be a reasonable alternative to NSAIDs for the treatment of acute pain as a result of gout.

Fenofibrate Decreases Plasma Uric Acid Concentration, Gout Events in T2D

Fenofibrate Decreases Plasma Uric Acid Concentration, Gout Events in T2D

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Fenofibrate may be a valuable adjunct therapy in type 2 diabetes to reduce the burden of gout.

Allopurinol Dose Escalation May Not Improve Survival in Patients With Gout

Allopurinol Dose Escalation May Not Improve Survival in Patients With Gout

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Investigators sought to determine whether allopurinol dose escalation is associated with all-cause mortality.

Ultrasound Reliably Identifies Calcium Pyrophosphate Deposition Disease

Ultrasound Reliably Identifies Calcium Pyrophosphate Deposition Disease

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Ultrasound is a reliable diagnostic tool for identifying calcium pyrophosphate deposition disease.

Febuxostat vs Allopurinol Evaluated in Patients With Gout, CVD

Febuxostat vs Allopurinol Evaluated in Patients With Gout, CVD

Febuxostat is noninferior to allopurinol for rates of adverse CV events but is associated with higher all-cause and CV mortality in patients with gout and CVD.

Development of Clinically Evident Gout: A Closer Look at Elevated Serum Urate Levels

Development of Clinically Evident Gout: A Closer Look at Elevated Serum Urate Levels

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Serum urate level is a strong predictor of incident gout, but only about half of patients with hyperuricemia develop clinically evident gout.

Ocular Complications of Gout: The Spectrum of Urate Crystal Deposition

Ocular Complications of Gout: The Spectrum of Urate Crystal Deposition

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A patient with a history of uncontrolled gout presents with highly refractile, crystal-like macular lesions.

Elevated Serum Uric Acid Levels May Increase Risk for Dementia in Older Adults

Elevated Serum Uric Acid Levels May Increase Risk for Dementia in Older Adults

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Risk for dementia may be increased with high serum uric acid levels in elderly individuals.

Examining the Connection Between Gout and Metabolic Syndrome

Examining the Connection Between Gout and Metabolic Syndrome

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Assessing the relationship between gout and the metabolic syndrome may provide insight into the management of both conditions.

Higher Monosodium Urate Crystal Depositions With Greater Disease Severity in Allopurinol-Treated Gout

Higher Monosodium Urate Crystal Depositions With Greater Disease Severity in Allopurinol-Treated Gout

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In patients with gout who are treated with allopurinol, monosodium urate crystal depositions are higher with evidence of greater disease severity.

Febuxostat Lowers Blood Pressure in Patients With Hyperuricemia and Hypertension

Febuxostat Lowers Blood Pressure in Patients With Hyperuricemia and Hypertension

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Febuxostat may lower blood pressure in patients with hyperuricemia, hypertension, and normal renal function.

Allopurinol Use May Lower Risk for Peripheral Arterial Disease

Allopurinol Use May Lower Risk for Peripheral Arterial Disease

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New allopurinol use was associated with a reduced risk of incident peripheral arterial disease.

Metoprolol Elevates Serum Uric Acid and Gout Risk in African Americans

Metoprolol Elevates Serum Uric Acid and Gout Risk in African Americans

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As the risk of developing gout is high in patients with hypertension, management of serum uric acid levels may improve patient outcomes.

Gout Flares Reduced by Febuxostat Increase Plus Low-Dose Colchicine

Gout Flares Reduced by Febuxostat Increase Plus Low-Dose Colchicine

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A stepwise dose increase in febuxostat plus low-dose colchicine prophylaxis was effective in the reduction of gout flares compared with febuxostat alone.

Gout Increases Incident Stroke Risk by the Same Magnitude as Diabetes

Gout Increases Incident Stroke Risk by the Same Magnitude as Diabetes

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A recent study assessed whether gout is a cardiovascular risk equivalent for stroke and myocardial infarction, similar to diabetes.

FDA Alert: Febuxostat May Increase Risk of Heart-Related Adverse Events, Death

FDA Alert: Febuxostat May Increase Risk of Heart-Related Adverse Events, Death

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Gout medication febuxostat (Uloric) was associated with an increased risk of heart-related death and death from all causes.

Online Consultation System Benefits Rheumatic Disease Management

Online Consultation System Benefits Rheumatic Disease Management

The SSDM series of applications is cost-effective for patients of rheumatologists.

Treatment Options to Explore When Serum Uric Acid Targets Are Not Attained

Treatment Options to Explore When Serum Uric Acid Targets Are Not Attained

Machelle Manuel, PhD, discusses further gout treatment options to consider when target serum urate levels are not attained.

High-Dose Lesinurad Deemed Unsuitable as Monotherapy for Gout

High-Dose Lesinurad Deemed Unsuitable as Monotherapy for Gout

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Despite rapidly lowering serum uric acid levels, lesinurad cannot be recommended alone at 400 mg per day, due to substantial adverse events.

Gout Flares May Be Reduced With Febuxostat

Gout Flares May Be Reduced With Febuxostat

A recent clinical trial has shown promising results that the drug febuxostat is effective at reducing gout flares in adults with early gout.

FDA Approves Duzallo for Hyperuricemia Associated With Uncontrolled Gout

FDA Approves Duzallo for Hyperuricemia Associated With Uncontrolled Gout

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The US FDA has approved a new fixed-dose and dual-mechanism treatment option for uncontrolled gout.

Lesinurad, Febuxostat Combination Treatment Improves Tophaceous Gout Symptoms

Lesinurad, Febuxostat Combination Treatment Improves Tophaceous Gout Symptoms

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Patients with tophaceous gout undergoing combination therapy with lesinurad and febuxostat showed a greater degree of symptom resolution than with febuxostat monotherapy.

Recall: Gout Pills Found in Platelet Inhibitor Sample Bottle

Recall: Gout Pills Found in Platelet Inhibitor Sample Bottle

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Accidental patient dosing with Zurampic can potentially cause adverse renal effects such as acute renal failure; this is more common if Zurampic is given alone without a xanthine oxidase inhibitor.

Analysis of Factors Improving Rx Adherence in Patients with Gout

Analysis of Factors Improving Rx Adherence in Patients with Gout

Belief about medicines, presence of comorbidity, and being married positively influence adherence to medication.

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