Lupus

Diffuse Alveolar Hemorrhage in SLE Associated With Serious Disease Flare

Diffuse Alveolar Hemorrhage in SLE Associated With Serious Disease Flare

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This condition is associated with serious disease flare complicated by sepsis and a high mortality rate.

Biomarkers of Pulmonary Arterial Hypertension Risk in SLE

Biomarkers of Pulmonary Arterial Hypertension Risk in SLE

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Meta-analysis supports anti-RNP and anti-Sm antibodies as serological biomarkers of PAH risk in patients with systemic lupus erythematosus.

Patients With Systemic Lupus Erythematosus and Cognitive Dysfunction Prevalence

Patients With Systemic Lupus Erythematosus and Cognitive Dysfunction Prevalence

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MOCA is more effective than the Mini-Mental State Examination at detecting cognitive dysfunction.

Patients With Lupus Have Poor Quality of Sleep, Quality of Life

Patients With Lupus Have Poor Quality of Sleep, Quality of Life

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The majority of patients with systemic lupus erythematosus have poor quality of sleep.

Steroid Dosage as Risk Factor for Osteonecrosis in Patients With SLE

Steroid Dosage as Risk Factor for Osteonecrosis in Patients With SLE

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Cumulative steroid dosage is a risk factor for the development of osteonecrosis.

Lymphoma in Patients With Systemic Lupus Erythematosus: Expert Insights

Lymphoma in Patients With Systemic Lupus Erythematosus: Expert Insights

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In this expert interview, Sasha Bernatsky, MD, PhD, and Michelle Petri, MD, MPH, discuss the risk of non-Hodgkin lymphoma in SLE.

Lupus Severity, Treatment Affected By Socioeconomic Disparities

Lupus Severity, Treatment Affected By Socioeconomic Disparities

Socioeconomic and racial disparities are linked in the severity and treatment of lupus.

Lupus Low-disease Activity State Can Predict Flare-up Risk

Lupus Low-disease Activity State Can Predict Flare-up Risk

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Asia-Pacific Lupus Collaborative's low-disease activity score can predict risk of flare-ups, according to research from a group at Hong Kong University.

Reduced Lupus Risk Linked to Moderate Alcohol Consumption in Women

Reduced Lupus Risk Linked to Moderate Alcohol Consumption in Women

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The study evaluated 2 groups of women from the Nurses' Health Study (NHS) and NHSII cohorts, examining alcohol consumption and the onset of systemic lupus erythematosus.

The Handoff: Your Week in Rheumatology News - 3/24/17

The Handoff: Your Week in Rheumatology News - 3/24/17

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New guidelines for rheumatoid arthritis treatment with DMARDs and money being steered into lupus research highlight this week's The Handoff.

Reduced Psychosocial Reserve Linked to Increased SLE Disease Burden

Reduced Psychosocial Reserve Linked to Increased SLE Disease Burden

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Patients with systemic lupus erythematosus and low self-esteem reported higher levels of anxiety and depression.

Elevated Disease Markers Identified in Relatives of Patients With Lupus

Elevated Disease Markers Identified in Relatives of Patients With Lupus

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Changes in levels of soluble mediators may predict SLE transition in unaffected relatives of patients.

Lupus Family Planning Recommendations Issued by EULAR

Lupus Family Planning Recommendations Issued by EULAR

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A European League Against Rheumatism writing committee has issued recommendations for family planning for women with systemic lupus erythematosus and antiphospholipid syndrome based on a systemic review.

Lupus: Using Diet and Nutrition to Improve Symptoms and Outcomes

Lupus: Using Diet and Nutrition to Improve Symptoms and Outcomes

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Consuming adequate amounts of the right nutrients, and limiting others, can help relieve symptoms and improve outcomes in patients with systemic lupus erythematosus.

Lupus Among Autoimmune Diseases Tied to Subsequent Dementia Risk

Lupus Among Autoimmune Diseases Tied to Subsequent Dementia Risk

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Study reviewed information from 1.8 million individuals in England admitted to a hospital with an autoimmune disease.

The Handoff: Your Week in Rheumatology News - 2/17/17

The Handoff: Your Week in Rheumatology News - 2/17/17

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Clinical management recommendations for juvenile dermatomyositis, updated guidelines for low back pain treatment, and more of this week's news.

Lupus Research Grants Available for Post-Graduate Study

Lupus Research Grants Available for Post-Graduate Study

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The Lupus Foundation of America is now accepting applications for 8 grants, with dedicated awards to minority applicants, pediatric research, and research that has an impact on rural areas.

<i>In Vitro</i> Fertilization is Safe and Effective in SLE and APS

In Vitro Fertilization is Safe and Effective in SLE and APS

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Study evaluated the complications and success rates for IVF in women with systemic lupus erythematosus or antiphospholipid syndrome.

Systemic Lupus Erythematosus Increases Incidence of High-Risk HPV

Systemic Lupus Erythematosus Increases Incidence of High-Risk HPV

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Three-year follow-up shows statistically significant increase in cumulative presence of HPV infection.

Depression in Systemic Lupus Erythematosus Linked to Cardiovascular Disease

Depression in Systemic Lupus Erythematosus Linked to Cardiovascular Disease

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Women with systemic lupus erythematosus and depression were more likely to have increased carotid intima-media thickness compared with those with SLE without depression.

No Increased Risk of CV Death in Cutaneous Lupus Erythematosus

No Increased Risk of CV Death in Cutaneous Lupus Erythematosus

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Patients with cutaneous lupus erythematosus (CLE) were assessed for their risk of cerebrovascular accidents, ischemic heart disease, and peripheral arterial disease.

Efficacy of Targeted Interferon-α Inhibition in SLE

Efficacy of Targeted Interferon-α Inhibition in SLE

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Eligible participants participated in a phase IIb trial of sifalimumab to determine the drug's effect on moderate-to-severe active SLE.

EULAR Updates Recommendations for Reproductive Planning in SLE

EULAR Updates Recommendations for Reproductive Planning in SLE

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Multidisciplinary experts provide 12 recommendations for the planning and management of pregnancy in systemic lupus erythematosus and/or antiphospholipid syndrome.

Long-Term Rates of SLE Flares After Clinical Remission

Long-Term Rates of SLE Flares After Clinical Remission

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Retrospective data from a single center showed that 22.4% of patients with SLE will have a disease flare even after 3 years of remission. What are the implications for clinical follow-up?

New IFN-α Monoclonal Antibody Effective in Moderate to Severe SLE

New IFN-α Monoclonal Antibody Effective in Moderate to Severe SLE

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A greater percentage of patients who received sifalimumab achieved an SLE responder index response at week 52 compared with placebo.

Revisiting SLE-Related Intestinal Pseudo-Obstruction

Revisiting SLE-Related Intestinal Pseudo-Obstruction

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Intestinal pseudo-obstruction has been considered a rare complication of SLE, but the condition has not been well defined, with most information coming from case reports.

SLE Associated With Elevated Risk for Atherosclerosis

SLE Associated With Elevated Risk for Atherosclerosis

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Atherosclerosis was found to be prevalent among Danish patients with lupus without prior cardiovascular disease. Research demonstrated that atherosclerosis screening focused on one vascular territory is insufficient to make a diagnosis.

Unbalanced B-cell Receptor Signaling Promotes B-cell Survival in SLE

Unbalanced B-cell Receptor Signaling Promotes B-cell Survival in SLE

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An imbalance between serine and tyrosine phosphatases contributes to a dysregulation of B-cell receptor signaling in patients with SLE.

Improvements in Muscle Strength May Reduce Disability in SLE

Improvements in Muscle Strength May Reduce Disability in SLE

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A study was conducted examining the correlation between muscle strength, muscle mass, and physical disability in adult women with SLE. The researchers found that muscle strength was inversely related to physical disability in SLE.

Incidence of ASCVD  Increased in African Americans and Young Adults With Inflammatory CTD

Incidence of ASCVD Increased in African Americans and Young Adults With Inflammatory CTD

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CTD is associated with higher prevalence of atherosclerotic cardiovascular disease in African Americans and in young adults.

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