Osteoarthritis

Sprifermin Improved Cartilage Morphology, Thickness in Knee Osteoarthritis

Sprifermin Improved Cartilage Morphology, Thickness in Knee Osteoarthritis

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Sprifermin has a positive effect on cartilage morphology and cartilage thickness in radiographic knee osteoarthritis.

Depressive Symptom Onset Linked to Disease Severity in Knee OA

Depressive Symptom Onset Linked to Disease Severity in Knee OA

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To effectively treat individuals with radiographic knee OA and comorbid depressive disorder, it is necessary to use a combined treatment strategy of 2 interventions delivered in parallel to simultaneously target each condition.

RA Associated With Greater Reduction in Short-Term Disease Burden vs Osteoarthritis

RA Associated With Greater Reduction in Short-Term Disease Burden vs Osteoarthritis

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Investigators analyzed MDHAQ/RAPID3 scores in patients with osteoarthritis or rheumatoid arthritis to assess disease burden associated with each rheumatic disease.

Zoledronic Acid May Not Improve Knee Osteoarthritis-Related Pain, Function Long-Term

Zoledronic Acid May Not Improve Knee Osteoarthritis-Related Pain, Function Long-Term

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Zoledronic acid did not significantly reduce knee pain or bone marrow lesion size overall in patients with knee osteoarthritis over 24 months.

NSAID Use Mediates CVD Risk in Osteoarthritis

NSAID Use Mediates CVD Risk in Osteoarthritis

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Nonsteroidal anti-inflammatory drug use mediated a substantial amount of cardiovascular disease risk in osteoarthritis.

BMI May Sufficiently Capture Knee OA Risk Associated With Increased Localized Adiposity

BMI May Sufficiently Capture Knee OA Risk Associated With Increased Localized Adiposity

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Researchers sought to determine whether central or peripheral adiposity measures are associated with incident radiographic knee osteoarthritis independent of BMI.

Hormonal, Reproductive Factors Associated With Knee Osteoarthritis in Women

Hormonal, Reproductive Factors Associated With Knee Osteoarthritis in Women

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Investigators sought to determine whether female reproductive and hormonal factors affect the incidence of total knee arthroplasty for osteoarthritis.

The Reliable Change Index: A Novel Approach to Estimate Osteoarthritis Progression

The Reliable Change Index: A Novel Approach to Estimate Osteoarthritis Progression

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The Reliable Change Index may be an effective method for identifying changes in joint space width in clinical and research settings.

Treatment for Prosthetic Joint Infections Gets FDA's QIDP Designation

Treatment for Prosthetic Joint Infections Gets FDA's QIDP Designation

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PJI is a challenging complication of joint arthroplasty with few effective treatment options.

New Combination Drug Approved to Treat Hypertension and OA Pain

New Combination Drug Approved to Treat Hypertension and OA Pain

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Consensi combines amlodipine besylate, a calcium-channel blocker, and celecoxib, a nonsteroidal anti-inflammatory drug.

Efficacy, Safety of OnabotulinumtoxinA Assessed for Knee OA Treatment

Efficacy, Safety of OnabotulinumtoxinA Assessed for Knee OA Treatment

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Investigators sought to evaluate intra-articular onabotulinumtoxinA 400 U and 200 U in reducing symptoms of knee OA in patients with nociceptive pain.

Patient-Reported Swelling vs MRI-Defined Effusion-Synovitis in OA With Meniscal Tear

Patient-Reported Swelling vs MRI-Defined Effusion-Synovitis in OA With Meniscal Tear

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Researchers sought to investigate the cross-sectional association between patient-reported swelling and effusion-synovitis on MRI in patients with OA and meniscal tear.

Late-Life Mobility Limitations Linked to Obesity After Arthroplasty for OA in Women

Late-Life Mobility Limitations Linked to Obesity After Arthroplasty for OA in Women

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Baseline obesity is associated with an increased risk for late-life mobility limitations in women undergoing joint replacement for OA.

Oral Risedronate May Reduce Bone Resorption After Total Hip Arthroplasty

Oral Risedronate May Reduce Bone Resorption After Total Hip Arthroplasty

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Risedronate could significantly reduce periprosthetic bone resorption in patients undergoing total hip arthroplasty.

Influence of Psychosocial, Sociodemographic Factors on Knee Osteoarthritis-Associated Pain

Influence of Psychosocial, Sociodemographic Factors on Knee Osteoarthritis-Associated Pain

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A set of psychosocial and sociodemographic factors may be associated with pain levels in patients with knee osteoarthritis.

Provider Counseling for Weight Loss Up for Arthritis, Obesity

Provider Counseling for Weight Loss Up for Arthritis, Obesity

In 2014, healthcare provider counseling for weight loss for adults with arthritis and overweight or obesity was 45.5%, which increased from 10.4% in 2002.

Myocardial Infarction Risk in Osteoarthritis, Spondyloarthritis Linked to Certain NSAIDs

Myocardial Infarction Risk in Osteoarthritis, Spondyloarthritis Linked to Certain NSAIDs

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The risk for myocardial infarction in patients with spondyloarthritis is increased in patients taking diclofenac, but not in patients taking naproxen.

Zilretta Benefits "Real-World" Patients With Knee OA, Says Study

Zilretta Benefits "Real-World" Patients With Knee OA, Says Study

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Interim data have been released from a phase 3b, open-label study that evaluated the safety and tolerability of repeat administration of Zilretta in patients with knee osteoarthritis.

Examining Unmet Needs of Joint Disease Associated With Calcium Pyrophosphate Crystal Deposition

Examining Unmet Needs of Joint Disease Associated With Calcium Pyrophosphate Crystal Deposition

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Addressing the challenges associated with clinical management of calcium pyrophosphate crystal deposition must start with understanding the unmet needs of associated joint damage and establishing a clearly defined strategy to address these needs.

Prevalence of Arthritis Assessed in the United States

Prevalence of Arthritis Assessed in the United States

Men, non-Hispanic blacks, and participants with low income or obesity had the most pronounced decrease in RA prevalence.

Tibiofemoral MRI May Be Predictive of Radiographic Knee OA in Overweight, Obese Women

Tibiofemoral MRI May Be Predictive of Radiographic Knee OA in Overweight, Obese Women

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Researchers sought to determine the predictive value of tibiofemoral MRI, patellofemoral MRI, and KLG1 for the incidence of clinical or radiographic knee OA.

GI Safety Compared for NSAIDs in Patients With Arthritis

GI Safety Compared for NSAIDs in Patients With Arthritis

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The randomized, double-blind, controlled trial (N=24,081) included patients with rheumatoid arthritis or osteoarthritis who required chronic NSAID treatment.

Intramuscular Triamcinolone Acetate Injection for OA Hip Pain

Intramuscular Triamcinolone Acetate Injection for OA Hip Pain

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In patients with painful hip osteoarthritis, an intramuscular glucocorticoid injection may effectively alleviate hip pain in the short-term.

Radiofrequency Ablation for Chronic Hip Pain in Osteoarthritis: Reviewing the Evidence

Radiofrequency Ablation for Chronic Hip Pain in Osteoarthritis: Reviewing the Evidence

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The available evidence suggests that radiofrequency ablation is a feasible treatment option for chronic hip pain associated with degenerative diseases.

Subcutaneous vs Intravenous Tanezumab for Knee, Hip Osteoarthritis

Subcutaneous vs Intravenous Tanezumab for Knee, Hip Osteoarthritis

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Intravenous and subcutaneous administration of tanezumab may provide similar analgesia and tolerability in patients with hip or knee osteoarthritis.

Bariatric Surgery Lessens Knee OA Pain More in Certain Patients

Bariatric Surgery Lessens Knee OA Pain More in Certain Patients

Laparoscopic gastric band surgery is associated with more improvement in knee osteoarthritis in younger patients and in patients without prior knee injury.

Intra-articular Knee Injection Increases Intraocular Pressure in Osteoarthritis

Intra-articular Knee Injection Increases Intraocular Pressure in Osteoarthritis

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Intraocular pressure was increased in patients who underwent a triamcinolone steroid knee injection, but not in patients who received a hyaluronic acid knee injection.

Managing Dietary Supplements and Complementary Medicines in Osteoarthritis

Managing Dietary Supplements and Complementary Medicines in Osteoarthritis

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Dietary supplements are widely used by patients with osteoarthritis, but the safety and efficacy of supplements remain unclear and are often misconstrued by mainstream media.

Total Hip Arthroplasty Revision Rate Examined From 2007 to 2013

Total Hip Arthroplasty Revision Rate Examined From 2007 to 2013

Patients aged 45 to 64 had an increase in the total hip arthroplasty revision rate from 2007 to 2013.

Reproductive, Hormonal Factors Affect Risk for Total Knee Arthroplasty in Women

Reproductive, Hormonal Factors Affect Risk for Total Knee Arthroplasty in Women

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Researchers sought to identify associations of female reproductive factors with incidence of total knee arthroplasty in osteoarthritis.

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