Osteoporosis

Denosumab Promising for TDT-Induced Osteoporosis Treatment

Denosumab Promising for TDT-Induced Osteoporosis Treatment

Denosumab may be beneficial for managing transfusion-dependent thalassemia-induced osteoporosis.

An Intermediary Role for Insulin Resistance in the Adipose-Bone Mass Relationship in Adolescents

An Intermediary Role for Insulin Resistance in the Adipose-Bone Mass Relationship in Adolescents

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Insulin resistance may play an intermediary role in the relationship between adiposity and lumbar spine bone mass in adolescents.

High Bone Mineral Density Predicts Progression of Knee, Hip Osteoarthritis

High Bone Mineral Density Predicts Progression of Knee, Hip Osteoarthritis

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Researchers examined the longitudinal relationship between bone mineral density and the incidence and progression of knee, hip, and hand osteoarthritis.

Vitamin D Supplementation Has No Effect on Musculoskeletal Health

Vitamin D Supplementation Has No Effect on Musculoskeletal Health

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There is little justification for the use of vitamin D supplements to maintain or improve musculoskeletal health.

RAAS Inhibitors Do Not Increase Fracture Risk, Osteoporosis in Postmenopausal Women

RAAS Inhibitors Do Not Increase Fracture Risk, Osteoporosis in Postmenopausal Women

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RAAS inhibitors do not have a deleterious effect on skeletal health in postmenopausal women.

Zoledronate Lowers Fracture Risk in Women With Osteopenia

Zoledronate Lowers Fracture Risk in Women With Osteopenia

The risk for fragility fractures is significantly lower in women with osteopenia who receive zoledronate than in those who receive placebo.

Diabetes Associated With Elevated Risk for Arthritis, Osteoporosis

Diabetes Associated With Elevated Risk for Arthritis, Osteoporosis

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Osteoarthritis was the most common form of arthritis in patients with diabetes but rheumatoid arthritis had the most pronounced association with diabetes.

Bone Mineral Density Improved With Intravenous Ibandronate in Osteoporosis

Bone Mineral Density Improved With Intravenous Ibandronate in Osteoporosis

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Investigators assessed the effectiveness of intravenous ibandronate on bone mineral density in patients with osteoporosis who did not respond to oral bisphosphonates.

Drug Holidays May Reduce Risk for Atypical Femur Fracture

Drug Holidays May Reduce Risk for Atypical Femur Fracture

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Bisphosphonate holidays of 3 to 5 years have been recommended as a means of achieving the antifracture benefit of the medication.

Effects of Vitamin D3 Treatment on Bone Strength in Postmenopausal Women

Effects of Vitamin D3 Treatment on Bone Strength in Postmenopausal Women

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Investigators sought to determine the effects of vitamin D3 supplementation in postmenopausal women with low serum 25(OH)D and high parathyroid hormone levels.

Early Life Exposures Affect Bone Density in Young Adulthood

Early Life Exposures Affect Bone Density in Young Adulthood

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Early life exposures, such as maternal smoking and breastfeeding, may have effects on bone mineral density in young adulthood.

Bone Mineral Density Changes After Anastrozole in Postmenopausal Women

Bone Mineral Density Changes After Anastrozole in Postmenopausal Women

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In postmenopausal women who were randomly assigned anastrozole, bone mineral density showed significant improvement at the lumbar spine.

Glucocorticoids Linked to Significant Bone Deficit in Pediatric Crohn Disease

Glucocorticoids Linked to Significant Bone Deficit in Pediatric Crohn Disease

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Glucocorticoid therapy was linked to significant bone deficits across multiple axial sites, regardless of disease activity.

MicroRNAs Linked to Increased Cortical Bone Porosity in Postmenopausal Women With History of Fracture

MicroRNAs Linked to Increased Cortical Bone Porosity in Postmenopausal Women With History of Fracture

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Findings suggest potential pathomechanistic links between miRNAs and cortical porosity. .

Effects of Concurrent Osteoarthritis, Osteoporosis on Bone Quality in Postmenopausal Women

Effects of Concurrent Osteoarthritis, Osteoporosis on Bone Quality in Postmenopausal Women

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Researchers sought to determine the differences in muscle and bone quality in postmenopausal women with osteoporosis, osteoarthritis, or both.

Consensus-Based Recommendations Released to Improve Osteoporosis Diagnosis, Treatment

Consensus-Based Recommendations Released to Improve Osteoporosis Diagnosis, Treatment

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The ASBMR Secondary Fracture Prevention Initiative Coalition outlined recommendations to improve efforts to increase diagnosis and treatment of individuals who are at high risk for osteoporosis.

Risk for Subsequent Osteoporotic Fracture Elevated in Men vs Women

Risk for Subsequent Osteoporotic Fracture Elevated in Men vs Women

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The risk for subsequent osteoporotic fracture was elevated for both sexes over a 25-year follow-up period.

Fifteen Genetic Determinants of Fracture Identified

Fifteen Genetic Determinants of Fracture Identified

Fifteen genetic determinants of fracture, which are also associated with bone mineral density, have been identified.

Advanced Glycation End Products and esRAGE Predict Hip Fractures in Older Men

Advanced Glycation End Products and esRAGE Predict Hip Fractures in Older Men

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Investigators assess whether circulating advanced glycation end products and esRAGE were associated with bone turnover and risk for fracture.

Poststroke Statin Therapy Associated With Lower Risk for Osteoporosis, Fractures

Poststroke Statin Therapy Associated With Lower Risk for Osteoporosis, Fractures

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A variety of underlying mechanisms may be attributed to the role of statins in preventing bone-related disorders.

Lower Postoperative Mortality With Hip Fracture Surgery on Day of Admission

Lower Postoperative Mortality With Hip Fracture Surgery on Day of Admission

Postoperative mortality is lower for medically stable older patients who undergo surgery for hip fracture on the day of admission or the following day.

Influence of Weight Loss, Resistance Training, and Aerobic Training on Bone Health

Influence of Weight Loss, Resistance Training, and Aerobic Training on Bone Health

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Investigators assessed the effect of exercise modality during dietary-induced on bone health.

Sedation Level After Hip Fracture Repair May Not Affect Delirium Risk

Sedation Level After Hip Fracture Repair May Not Affect Delirium Risk

For older patients undergoing hip fracture repair, the level of sedation does not affect delirium risk overall.

Real-World Data Show Reduced Fracture Rates in Teriparatide-Treated Osteoporosis

Real-World Data Show Reduced Fracture Rates in Teriparatide-Treated Osteoporosis

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Rates of incident clinical vertebral fracture, incident nonvertebral fracture, hip fracture, and clinical fractures decreased 6 months after initiation of teriparatide.

Genetic Screening May Predict Osteoporosis and Fracture Risk

Genetic Screening May Predict Osteoporosis and Fracture Risk

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Genetic testing may identify individuals with an increased risk for osteoporosis and bone fracture.

One-Third of Canadian Patients Get Hip Fracture Repair Within 24 Hours

One-Third of Canadian Patients Get Hip Fracture Repair Within 24 Hours

Only one-third of Canadian patients received hip fracture repair surgery within the desired 24 hours.

HbA1c-Corrected FRAX Score May Better Predict Fracture Risk in Type 2 Diabetes

HbA1c-Corrected FRAX Score May Better Predict Fracture Risk in Type 2 Diabetes

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A corrected HbA1c factor may improve the ability to predict the risk for fracture by the FRAX algorithm in T2D.

Decreased Osteoporosis Treatment Initiation Observed After Hip Fracture

Decreased Osteoporosis Treatment Initiation Observed After Hip Fracture

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Researchers observed a reduction in subsequent nonvertebral fracture rates in patients who initiated osteoporosis treatment.

Effect of Mediterranean Diet Plus Vitamin D3 on Bone Density in Osteoporosis

Effect of Mediterranean Diet Plus Vitamin D3 on Bone Density in Osteoporosis

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Investigators examined the effect of consuming a Mediterranean-style diet for 1 year on inflammatory response and bone health in the elderly.

Empagliflozin Does Not Increase Fracture Risk in Type 2 Diabetes

Empagliflozin Does Not Increase Fracture Risk in Type 2 Diabetes

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The risk for bone fractures was not increased in patients with type 2 diabetes using empagliflozin compared with placebo or glimepiride.

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