Rheumatoid Arthritis Headlines

Precision Medicine in Rheumatology: Personalizing Treatment for Improved Clinical Outcomes

Precision Medicine in Rheumatology: Personalizing Treatment for Improved Clinical Outcomes

Judith A. James, MD, PhD, discusses the developments of precision medicine in rheumatology at the 2018 State-of-the-Art Clinical Symposium.

GI Safety Compared for NSAIDs in Patients With Arthritis

GI Safety Compared for NSAIDs in Patients With Arthritis

The randomized, double-blind, controlled trial (N=24,081) included patients with rheumatoid arthritis or osteoarthritis who required chronic NSAID treatment.

Certain RA Treatments Tied to Improvements in Blood Pressure

Certain RA Treatments Tied to Improvements in Blood Pressure

Certain disease-modifying therapies for rheumatoid arthritis may have a positive effect on blood pressure.

Biosimilar Etanercept SB4 May Decrease Disease Activity in Inflammatory Rheumatic Disease

Biosimilar Etanercept SB4 May Decrease Disease Activity in Inflammatory Rheumatic Disease

Nonmandatory transitioning from originator etanercept to biosimilar etanercept SB4 using a specifically designed communication strategy showed a slightly lower persistence rate and smaller decreases in disease activity.

Quality of Life in Rheumatoid Arthritis Improved With Filgotinib

Quality of Life in Rheumatoid Arthritis Improved With Filgotinib

The results of 2 randomized controlled trials showed that filgotinib improved quality of life when given in combination with methotrexate or as monotherapy in rheumatoid arthritis.

Women With SLE Become Pregnant More Easily vs Women With Rheumatoid Arthritis

Women With SLE Become Pregnant More Easily vs Women With Rheumatoid Arthritis

Researchers examined differences in the ability to get pregnant in women with systemic lupus erythematosus and rheumatoid arthritis.

Higher Preoperative Disease Activity Linked to RA Flares After Arthroplasty

Higher Preoperative Disease Activity Linked to RA Flares After Arthroplasty

Higher preoperative disease activity increased risk for postoperative flares in patients with rheumatoid arthritis who underwent total hip arthroplasty or total knee arthroplasty.

Risk Factors for Oral Methotrexate Failure Identified in Inflammatory Polyarthritis

Risk Factors for Oral Methotrexate Failure Identified in Inflammatory Polyarthritis

Investigators sought to evaluate the rate and predictors of oral methotrexate failure.

Sirukumab Effective in Rheumatoid Arthritis Refractory to Methotrexate or Sulfasalazine

Sirukumab Effective in Rheumatoid Arthritis Refractory to Methotrexate or Sulfasalazine

In patients with rheumatoid arthritis refractory to methotrexate and sulfasalazine, sirukumab monotherapy is generally tolerable with measurable efficacy over the course of 52 weeks.

FDA Label Update for Certolizumab Pegol Affects Women of Childbearing Age

FDA Label Update for Certolizumab Pegol Affects Women of Childbearing Age

The FDA has approved a label update to include pharmacokinetic data showing low transfer of certolizumab pegol through placenta and minimal transfer to breast milk from mother to infant.

Novel Gene Variants Associated With CVD Identified in Patients With SLE and RA

Novel Gene Variants Associated With CVD Identified in Patients With SLE and RA

The IL-19 risk allele is associated with stroke and myocardial infarction in patients with systemic lupus erythematosus and rheumatoid arthritis, but not in the general population.

Biologic Use During Pregnancy Not Linked to Risk for Preterm Delivery

Biologic Use During Pregnancy Not Linked to Risk for Preterm Delivery

Researchers assessed the risk for preterm delivery and small-for-gestational-age births in women with autoimmune diseases using biologics during pregnancy.

Bone Strength Significantly Lower in Patients With ACPA-Positive Rheumatoid Arthritis

Bone Strength Significantly Lower in Patients With ACPA-Positive Rheumatoid Arthritis

Results confirm that failure load and stiffness of bone are significantly impaired in men and women with rheumatoid arthritis.

MRI-Detected Erosions May Not Be Specific to Rheumatoid Arthritis

MRI-Detected Erosions May Not Be Specific to Rheumatoid Arthritis

Erosions may also be detected in patients with other arthritides and in symptom-free individuals.

Synovial Joint Biopsy Techniques: Arthroscopy vs Ultrasound-Guided Methods

Synovial Joint Biopsy Techniques: Arthroscopy vs Ultrasound-Guided Methods

Data support the integration of ultrasound-guided methods along with arthroscopy into clinical trial protocols requiring sequential joint sampling for subsequent histological and molecular analysis.

Rheumatoid Arthritis and Diabetes: Reducing Cardiovascular Risk

Rheumatoid Arthritis and Diabetes: Reducing Cardiovascular Risk

For patients with rheumatoid arthritis, abatacept conferred a greater reduction in CVD risk compared with TNF inihibitors.

Rheumatoid Arthritis Exposure In Utero Increases Chronic Disease Risk in Children

Rheumatoid Arthritis Exposure In Utero Increases Chronic Disease Risk in Children

Maternal RA exposure in utero may increase the risk for certain chronic conditions, including RA, thyroid disease, and epilepsy.

Predicting Loss of Remission in RA Treated With Etanercept-Methotrexate

Predicting Loss of Remission in RA Treated With Etanercept-Methotrexate

Investigators sought to determine which characteristics are predictive of remission induction and subsequent loss of remission in patients with moderately active RA.

Adalimumab Effective in JIA-Associated Uveitis Unresponsive to Methotrexate

Adalimumab Effective in JIA-Associated Uveitis Unresponsive to Methotrexate

Adalimumab was well tolerated and associated with persistent uveitis improvement in most cases.

Topical vs Oral NSAIDs for Rheumatoid Arthritis: Examining Cardiovascular Risks

Topical vs Oral NSAIDs for Rheumatoid Arthritis: Examining Cardiovascular Risks

Researchers assessed the rates of composite cardiovascular events in people with RA using NSAIDs to treat musculoskeletal pain.

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