Rheumatoid Arthritis

RA Treatment During Pregnancy: Is Infection Risk Greater in Offspring?

RA Treatment During Pregnancy: Is Infection Risk Greater in Offspring?

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Children exposed to TNFi's during the gestational period were found not to have a significantly higher risk of developing serious infections.

HBV Status Linked to Disease Activity and Progression in Rheumatoid Arthritis

HBV Status Linked to Disease Activity and Progression in Rheumatoid Arthritis

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Patients with rheumatoid arthritis with chronic hepatitis B virus infection demonstrated greater radiographic progression and poorer clinical response at 1 year.

Risks Associated With Co-Administration of Aspirin and Other NSAIDs

Risks Associated With Co-Administration of Aspirin and Other NSAIDs

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In patients with rheumatoid arthritis or osteoarthritis who are at higher risk for cardiovascular events, celecoxib may be safer compared with naproxen or ibuprofen when these drugs are taken alone or in combination with aspirin.

Corticosteroid-Related Adverse Events Examined Based on Dose, Duration

Corticosteroid-Related Adverse Events Examined Based on Dose, Duration

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Using a privately-insured administrative database, researchers examined a total of 78,704 patients with autoimmune or inflammatory disease diagnoses between 2006 and 2015.

RA: Low Probability of Achieving LDA With Lack of Early Response to Tofacitinib

RA: Low Probability of Achieving LDA With Lack of Early Response to Tofacitinib

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This study sought to examine the link between early disease activity changes and attainment of LDA and remission targets in tofacitinib-treated patients with RA.

Severe Obesity Linked to Rapid Progression of Disability in Rheumatoid Arthritis

Severe Obesity Linked to Rapid Progression of Disability in Rheumatoid Arthritis

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Severe obesity is associated with more rapid progression of disability in rheumatoid arthritis.

Patients With Rheumatic Diseases Need to Be Monitored for HBV Reactivation

Patients With Rheumatic Diseases Need to Be Monitored for HBV Reactivation

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Clinicians need to monitor reactivation of the hepatitis B virus in patients with rheumatic diseases by testing for elevation of liver enzymes and HBV DNA levels.

Temporary Methotrexate Discontinuation in RA: Ensuring Vaccination Immunogenicity

Temporary Methotrexate Discontinuation in RA: Ensuring Vaccination Immunogenicity

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Rheumatologists should coordinate with the patient's primary care provider to facilitate an effective and comprehensive vaccination schedule.

Incidence of Cardiovascular Events Similar in Rheumatoid Arthritis, Spondyloarthritis

Incidence of Cardiovascular Events Similar in Rheumatoid Arthritis, Spondyloarthritis

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The incidence of adverse cardiovascular events in patients with RA do not differ significantly compared with those with PsA or axSpA.

Decreased Muscle Performance Linked to Increased Disease Activity in Rheumatoid Arthritis

Decreased Muscle Performance Linked to Increased Disease Activity in Rheumatoid Arthritis

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Poorer muscle performance composite scores are associated with increased Disease Activity Scores for 28 joints in patients with rheumatoid arthritis.

Effects of Certolizumab Pegol Exposure on Pregnancy Outcomes in Women With Rheumatic Disease

Effects of Certolizumab Pegol Exposure on Pregnancy Outcomes in Women With Rheumatic Disease

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Researchers sought to provide information on pregnancy outcomes, including major congenital malformations and other maternal and fetal adverse outcomes, in women treated with certolizumab pegol.

FDA Advisory Committee Recommends Against Approval of Baricitinib at Higher Dose for RA

FDA Advisory Committee Recommends Against Approval of Baricitinib at Higher Dose for RA

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The FDA advisory panel voted in favor of baricitinib for the treatment of rheumatoid arthritis, but only recommended approval of the 2 mg dose.

Precision Medicine in Rheumatology: Personalizing Treatment for Improved Clinical Outcomes

Precision Medicine in Rheumatology: Personalizing Treatment for Improved Clinical Outcomes

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Judith A. James, MD, PhD, discusses the developments of precision medicine in rheumatology at the 2018 State-of-the-Art Clinical Symposium.

GI Safety Compared for NSAIDs in Patients With Arthritis

GI Safety Compared for NSAIDs in Patients With Arthritis

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The randomized, double-blind, controlled trial (N=24,081) included patients with rheumatoid arthritis or osteoarthritis who required chronic NSAID treatment.

Expert Q&A: Effects of Collaborative Care Models on Patient Satisfaction in Rheumatoid Arthritis

Expert Q&A: Effects of Collaborative Care Models on Patient Satisfaction in Rheumatoid Arthritis

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John M. Davis III, MD, MS, from the Mayo Clinic in Rochester, Minnesota, and Jennifer Gorman, MD, MPH, from The Polyclinic in Seattle, Washington, discuss the evolving collaborative care therapy model in RA.

Certain RA Treatments Tied to Improvements in Blood Pressure

Certain RA Treatments Tied to Improvements in Blood Pressure

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Certain disease-modifying therapies for rheumatoid arthritis may have a positive effect on blood pressure.

Biosimilar Etanercept SB4 May Decrease Disease Activity in Inflammatory Rheumatic Disease

Biosimilar Etanercept SB4 May Decrease Disease Activity in Inflammatory Rheumatic Disease

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Nonmandatory transitioning from originator etanercept to biosimilar etanercept SB4 using a specifically designed communication strategy showed a slightly lower persistence rate and smaller decreases in disease activity.

Top-Line Results Announced for Investigational RA Treatment Upadacitinib

Top-Line Results Announced for Investigational RA Treatment Upadacitinib

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At week 12, results showed 71% in the upadacitinib group had achieved ACR20, compared to 63% and 36% in the adalimumab and placebo groups, respectively.

Quality of Life in Rheumatoid Arthritis Improved With Filgotinib

Quality of Life in Rheumatoid Arthritis Improved With Filgotinib

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The results of 2 randomized controlled trials showed that filgotinib improved quality of life when given in combination with methotrexate or as monotherapy in rheumatoid arthritis.

Women With SLE Become Pregnant More Easily vs Women With Rheumatoid Arthritis

Women With SLE Become Pregnant More Easily vs Women With Rheumatoid Arthritis

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Researchers examined differences in the ability to get pregnant in women with systemic lupus erythematosus and rheumatoid arthritis.

Higher Preoperative Disease Activity Linked to RA Flares After Arthroplasty

Higher Preoperative Disease Activity Linked to RA Flares After Arthroplasty

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Higher preoperative disease activity increased risk for postoperative flares in patients with rheumatoid arthritis who underwent total hip arthroplasty or total knee arthroplasty.

Risk Factors for Oral Methotrexate Failure Identified in Inflammatory Polyarthritis

Risk Factors for Oral Methotrexate Failure Identified in Inflammatory Polyarthritis

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Investigators sought to evaluate the rate and predictors of oral methotrexate failure.

Sirukumab Effective in Rheumatoid Arthritis Refractory to Methotrexate or Sulfasalazine

Sirukumab Effective in Rheumatoid Arthritis Refractory to Methotrexate or Sulfasalazine

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In patients with rheumatoid arthritis refractory to methotrexate and sulfasalazine, sirukumab monotherapy is generally tolerable with measurable efficacy over the course of 52 weeks.

FDA Label Update for Certolizumab Pegol Affects Women of Childbearing Age

FDA Label Update for Certolizumab Pegol Affects Women of Childbearing Age

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The FDA has approved a label update to include pharmacokinetic data showing low transfer of certolizumab pegol through placenta and minimal transfer to breast milk from mother to infant.

Novel Gene Variants Associated With CVD Identified in Patients With SLE and RA

Novel Gene Variants Associated With CVD Identified in Patients With SLE and RA

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The IL-19 risk allele is associated with stroke and myocardial infarction in patients with systemic lupus erythematosus and rheumatoid arthritis, but not in the general population.

Chikungunya Virus: What Every Rheumatologist Should Know

Chikungunya Virus: What Every Rheumatologist Should Know

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Chikungunya virus has become a disease of global concern due to its potentially disabling consequences and its efficient transmission.

Biologic Use During Pregnancy Not Linked to Risk for Preterm Delivery

Biologic Use During Pregnancy Not Linked to Risk for Preterm Delivery

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Researchers assessed the risk for preterm delivery and small-for-gestational-age births in women with autoimmune diseases using biologics during pregnancy.

Bone Strength Significantly Lower in Patients With ACPA-Positive Rheumatoid Arthritis

Bone Strength Significantly Lower in Patients With ACPA-Positive Rheumatoid Arthritis

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Results confirm that failure load and stiffness of bone are significantly impaired in men and women with rheumatoid arthritis.

MRI-Detected Erosions May Not Be Specific to Rheumatoid Arthritis

MRI-Detected Erosions May Not Be Specific to Rheumatoid Arthritis

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Erosions may also be detected in patients with other arthritides and in symptom-free individuals.

Pregnancy in Rheumatic Disease: Managing Potentially Teratogenic Medications

Pregnancy in Rheumatic Disease: Managing Potentially Teratogenic Medications

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Petros Efthimiou, MD, a rheumatologist at NYU Langone Health, discusses how clinicians should approach prescribing potentially teratogenic drugs in pregnancy.

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