Rheumatoid Arthritis

Meta-Analysis: RA Treatment Outcomes Post-Methotrexate Failure

Meta-Analysis: RA Treatment Outcomes Post-Methotrexate Failure

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The efficacy and tolerance of triple oral DMARD therapy vs. anti-TNF drugs plus methotrexate, was explored.

FDA Delays Approval of JAK Inhibitor Baricitinib

FDA Delays Approval of JAK Inhibitor Baricitinib

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After 3-month extension to review, regulator says NDA for baricitinib cannot be approved in its current form.

Rheumatoid Arthritis Increases Mortality Risk in <i>Staphylococcus aureus</i> Infections

Rheumatoid Arthritis Increases Mortality Risk in Staphylococcus aureus Infections

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Prospective cohort study examines clinical characteristics and outcomes of S aureus bacteremia in patients with rheumatoid arthritis.

Biosimilar Confidence: Physician-Patient Communication Sets the Tone

Biosimilar Confidence: Physician-Patient Communication Sets the Tone

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Jonathan Krant, MD, FACP, confronts the issues surrounding biosimilar substitution for biologic treatments.

The Handoff: Your Week in Rheumatology News - 4/14/17

The Handoff: Your Week in Rheumatology News - 4/14/17

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This week, a phase III trial for investigational drug voclosporin for lupus nephritis treatment was approved, prolonged insomnia may lead to less robust bone formation — causing osteoporosis and bone fractures — and researchers found that women who drink a moderate amount of alcohol daily have a reduced risk of developing systemic lupus erythmatosus.

Methotrexate-treated Rheumatoid Arthritis: No Liver Damage With Moderate Alcohol Use

Methotrexate-treated Rheumatoid Arthritis: No Liver Damage With Moderate Alcohol Use

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Study analyzed medical records to determine whether alcohol consumption increases hepatotoxic risk in patients with rheumatoid arthritis being treated with methotrexate.

Second Biologic Effective in Rheumatoid Arthritis After Initial Treatment Failure

Second Biologic Effective in Rheumatoid Arthritis After Initial Treatment Failure

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Investigators conduct a systematic review to evaluate the risks and benefits of biologics as monotherapy or in combination with methotrexate in patients with rheumatoid arthritis who have not responded to previous biologic treatment.

The Handoff: Your Week in Rheumatology News - 4/7/17

The Handoff: Your Week in Rheumatology News - 4/7/17

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WCO 2017, FDA grants Rituxan Breakthrough Therapy status, and a close-up of pediatric Sjögren's syndrome highlight this week's The Handoff.

FDA Grants Breakthrough Therapy Designation to Rituxan

FDA Grants Breakthrough Therapy Designation to Rituxan

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FDA gives breakthrough therapy designation to rituxan for treatment of pemphigus vulgaris and is indicated for treating rheumatoid arthritis

Rheumatoid Arthritis, Systemic Sclerosis Patients Should Have Hand Function Evaluated

Rheumatoid Arthritis, Systemic Sclerosis Patients Should Have Hand Function Evaluated

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Study evaluated hand function and potential influence of functional loss on patients' overall physical functions, health-related quality of life, and psychological status in patients with rheumatoid arthritis and systemic sclerosis.

JAK/STAT Inhibitors:  A New Treatment Target for Rheumatoid Arthritis

JAK/STAT Inhibitors: A New Treatment Target for Rheumatoid Arthritis

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Janus kinase and signal transducers and activators of transcription inhibitors represent promising treatment targets in RA.

Knee Osteoarthritis in Early Rheumatoid Arthritis May Affect Disease Activity Evaluation

Knee Osteoarthritis in Early Rheumatoid Arthritis May Affect Disease Activity Evaluation

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A small study from Romania evaluated whether the presence of osteoarthritis had an effect on the parameters used to evaluate disease activity in patients with early rheumatoid arthritis.

Ultrasound Finds Distinct Ankle Pathologies In Rheumatic Diseases

Ultrasound Finds Distinct Ankle Pathologies In Rheumatic Diseases

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Ultrasonography detects different ankle pathologies in various inflammatory rheumatic diseases.

Rheumatoid Arthritis Increases Nonischemic Heart Failure Risk

Rheumatoid Arthritis Increases Nonischemic Heart Failure Risk

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Study uses registry data from Sweden to evaluate heart failure risk before and after diagnosis of rheumatoid arthritis.

The Handoff: Your Week in Rheumatology News - 3/24/17

The Handoff: Your Week in Rheumatology News - 3/24/17

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New guidelines for rheumatoid arthritis treatment with DMARDs and money being steered into lupus research highlight this week's The Handoff.

Tocilizumab Highly Effective in Refractory Juvenile Idiopathic Arthritis-associated Uveitis

Tocilizumab Highly Effective in Refractory Juvenile Idiopathic Arthritis-associated Uveitis

Tocilizumab therapy showed rapid improvement in ocular parameters for uveitis in juvenile idiopathic arthritis patients.

Glucocorticoids for Early Rheumatoid Arthritis Demonstrate Good Long-term Safety

Glucocorticoids for Early Rheumatoid Arthritis Demonstrate Good Long-term Safety

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Researchers examined the long-term safety of glucocorticoid use in patients with early rheumatoid arthritis, defined as disease duration <6 months, from the multicenter observational Etude et Suivi des POlyarthrites Indifférenciées Récentes (ESPOIR) cohort.

EULAR Updates Rheumatoid Arthritis Treatment Guidelines for DMARDs

EULAR Updates Rheumatoid Arthritis Treatment Guidelines for DMARDs

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EULAR has released new recommendations for rheumatoid arthritis management with disease-modifying antirheumatic drugs.

Sirukumab Rapidly Improves Rheumatoid Arthritis Symptoms in Difficult-to-Treat Patients

Sirukumab Rapidly Improves Rheumatoid Arthritis Symptoms in Difficult-to-Treat Patients

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Study examined patients with active rheumatoid arthritis who failed to derive benefit from or were intolerant to TNF-inhibitor therapy.

Rheumatoid Arthritis Increases Heart Failure Risk

Rheumatoid Arthritis Increases Heart Failure Risk

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Analysis finds rapid increase in the risk of non-ischemic heart failure after onset of rheumatoid arthritis.

High-dose Steroids Increase Serious Infection Risk in Pregnant Women With Inflammatory Conditions

High-dose Steroids Increase Serious Infection Risk in Pregnant Women With Inflammatory Conditions

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An observational cohort study of 4961 women with completed pregnancies and a recorded diagnosis of systemic inflammatory conditions.

Arthritis Disability Up 20% Since 2002, Says CDC Report

Arthritis Disability Up 20% Since 2002, Says CDC Report

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One in four adults in the U.S. have been diagnosed with arthritis.

Secukinumab Improves Symptoms in TNF Inhibitor-Refractory Rheumatoid Arthritis

Secukinumab Improves Symptoms in TNF Inhibitor-Refractory Rheumatoid Arthritis

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A phase 3, double-blind, randomized placebo-controlled study was conducted in 551 patients with active rheumatoid arthritis who received secukinumab, abatacept, or placebo.

Minimal Amount of TNF Inhibitor Transfers to Breast Milk, Study Finds

Minimal Amount of TNF Inhibitor Transfers to Breast Milk, Study Finds

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Study evaluated breast milk samples from 17 lactating mothers diagnosed with rheumatoid arthritis, Crohn's disease, psoriatic arthritis, and axial spondyloarthritis/ankylosing spondylitis.

Lupus Among Autoimmune Diseases Tied to Subsequent Dementia Risk

Lupus Among Autoimmune Diseases Tied to Subsequent Dementia Risk

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Study reviewed information from 1.8 million individuals in England admitted to a hospital with an autoimmune disease.

The Handoff: Your Week in Rheumatology News - 3/3/17

The Handoff: Your Week in Rheumatology News - 3/3/17

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Connecticut considers rheumatoid arthritis and fibromyalgia for medical marijuana treatment, while Lyme disease-carrying deer ticks continue to invade Michigan. All this and more in this week's edition.

Arthritis and Incident Myocardial Infarction Risk

Arthritis and Incident Myocardial Infarction Risk

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Research comes from meta-analysis of 25 population-based studies on 5 major forms of arthritis.

Tocilizumab Cardiovascular Risk in Rheumatoid Arthritis

Tocilizumab Cardiovascular Risk in Rheumatoid Arthritis

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Cohort study of patients with rheumatoid arthritis who newly initiated tocilizumab or tumor necrosis factor inhibitor therapy using multi-database claims data.

Baricitinib Superior to Adalimumab for Rheumatoid Arthritis Treatment

Baricitinib Superior to Adalimumab for Rheumatoid Arthritis Treatment

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Phase 3 trial in patients taking baricitinib, adalimumab, or placebo in addition to methotrexate background therapy.

Cytomegalovirus Connection With Rheumatoid Arthritis Cardiovascular Disease Risk: An Expert Interview

Cytomegalovirus Connection With Rheumatoid Arthritis Cardiovascular Disease Risk: An Expert Interview

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Florian Kern, deputy director of research at Brighton and Sussex Medical School in the United Kingdom, discusses his recently published review wherein he and his colleagues make the case that cytomegalovirus is a major driver of cardiovascular disease in patients with rheumatoid arthritis.

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