Scleroderma

SPAR Model May Predict Mild Interstitial Lung Disease in Systemic Sclerosis

SPAR Model May Predict Mild Interstitial Lung Disease in Systemic Sclerosis

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The SPAR prediction model might be helpful for the risk stratification of mild ILD in patients with SSc in clinical practice.

PAH in Systemic Sclerosis Increases Risk for Early Mortality

PAH in Systemic Sclerosis Increases Risk for Early Mortality

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The majority of deaths in patients with systemic sclerosis-associated pulmonary arterial hypertension occurred within 4 years of diagnosis.

Sildenafil, Bosentan Combination vs Sildenafil Monotherapy in SSc-Associated PAH

Sildenafil, Bosentan Combination vs Sildenafil Monotherapy in SSc-Associated PAH

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There was no significant difference in efficacy between sildenafil and bosentan initial combination therapy and sildenafil monotherapy in patients with systemic sclerosis-related pulmonary arterial hypertension.

Smoking Not Associated With Systemic Sclerosis-Specific Cutaneous, Pulmonary Manifestations

Smoking Not Associated With Systemic Sclerosis-Specific Cutaneous, Pulmonary Manifestations

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Smoking status in patients with systemic sclerosis was not significantly associated with systemic sclerosis-specific cutaneous or pulmonary changes.

PAH-Associated Connective Tissue Diseases: A Case for Separating SSc, SLE

PAH-Associated Connective Tissue Diseases: A Case for Separating SSc, SLE

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Recent evidence suggests that systemic sclerosis and SLE in pulmonary arterial hypertension should be considered separate diseases.

LPA1 Receptor Antagonist SAR100842 Safe, Well Tolerated in Systemic Sclerosis

LPA1 Receptor Antagonist SAR100842 Safe, Well Tolerated in Systemic Sclerosis

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The investigational drug SAR100842 was safe, moderately effective, and well tolerated in patients with early diffuse cutaneous systemic sclerosis.

Expert Insight: Detecting Pulmonary Arterial Hypertension in Patients With Systemic Sclerosis

Expert Insight: Detecting Pulmonary Arterial Hypertension in Patients With Systemic Sclerosis

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Although pulmonary arterial hypertension occurs in a minority of patients with systemic sclerosis, clinicians must be attentive to it, as it can emerge at any point over the course of the disease.

Scleroderma Phenotype, Autoantibodies May Identify Patients at Risk for Cancer

Scleroderma Phenotype, Autoantibodies May Identify Patients at Risk for Cancer

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Stratification by clinical features and autoantibody response identify scleroderma subgroups with distinct risks for cancer.

Independent Predictors of VTE Identified in Systemic Sclerosis

Independent Predictors of VTE Identified in Systemic Sclerosis

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Researchers evaluated the prevalence, risk factors, and effect of venous thromboembolism on survival in systemic sclerosis.

Predicting Skin Score Changes in Early Diffuse Systemic Sclerosis

Predicting Skin Score Changes in Early Diffuse Systemic Sclerosis

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Two predictive models for progressive skin thickening in patients with early diffuse cutaneous systemic sclerosis were developed to use in clinical practice and to improve recruitment in clinical trials.

Social Anxiety in Systemic Sclerosis: Comparing Patient Assessment Tools

Social Anxiety in Systemic Sclerosis: Comparing Patient Assessment Tools

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Investigators assessed 3 versions of the Brief Fear of Negative Evaluation scale in patients with systemic sclerosis.

Scleroderma and Breast Cancer: Examining Outcomes of Radiation Therapy

Scleroderma and Breast Cancer: Examining Outcomes of Radiation Therapy

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Researchers sought to determine the prevalence of radiation complications in patients with systemic scleroderma and breast cancer.

Stem Cell Transplant May Benefit Patients With Systemic Sclerosis

Stem Cell Transplant May Benefit Patients With Systemic Sclerosis

Patients who underwent autologous hematopoietic stem cell transplant for systemic sclerosis saw improvements in quality of life.

PAH Incidence in Systemic Sclerosis: Does Algorithm Use Affect Reported Incidence?

PAH Incidence in Systemic Sclerosis: Does Algorithm Use Affect Reported Incidence?

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Use of the DETECT algorithm did not change incidence of PAH, but led to an increased frequency of cases of borderline pulmonary hypertension.

Early Scleroderma Disability May Be Affected by Skin Thickening, Poor Hand Function

Early Scleroderma Disability May Be Affected by Skin Thickening, Poor Hand Function

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These results likely indicate the importance of skin thickening in contributing to impairment of hand function.

Patients With Early SSc-PAH Development Have Substantial Rate of Disease Progression

Patients With Early SSc-PAH Development Have Substantial Rate of Disease Progression

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Patients with systemic sclerosis and early-diagnosed pulmonary arterial hypertension had disease progression over a relatively short period of time.

Predicting Mortality in Systemic Sclerosis-PAH With CT Signs of Veno-Occlusive Disease

Predicting Mortality in Systemic Sclerosis-PAH With CT Signs of Veno-Occlusive Disease

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A blinded analysis sought to determine whether CT signs of pulmonary veno-occlusive disease are common and predictive of mortality in patients with systemic sclerosis and pulmonary arterial hypertension.

Assessment of Life Expectancy in Scleroderma-Associated Pulmonary Arterial Hypertension

Assessment of Life Expectancy in Scleroderma-Associated Pulmonary Arterial Hypertension

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Patients with scleroderma-associated isolated pulmonary arterial hypertension (SSc-PAH) have a slightly higher mortality risk than patients SSc-PAH with concomitant interstitial lung disease.

Pulmonary Arterial Hypertension in Systemic Sclerosis: Swift Diagnosis and Effective Treatment

Pulmonary Arterial Hypertension in Systemic Sclerosis: Swift Diagnosis and Effective Treatment

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Rheumatology specialists should be aware of the clinical features of SSc-PAH, as well as the tools available to facilitate a prompt, accurate diagnosis.

Key Hemodynamic Differences Noted With Scleroderma-Associated PAH vs Idiopathic PAH

Key Hemodynamic Differences Noted With Scleroderma-Associated PAH vs Idiopathic PAH

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Patients with systemic sclerosis-associated pulmonary arterial hypertension display important differences in hemodynamic and pulmonary function parameters compared with patients with idiopathic PAH.

Systemic Sclerosis: Capillaroscopic and Ultrasonographic Evaluations

Systemic Sclerosis: Capillaroscopic and Ultrasonographic Evaluations

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Microvascular damage evaluated using nailfold capillaroscopy and macrovascular features that include ulnar artery occlusion, assessed per hand power Doppler ultrasonography, have demonstrated associations with the main digital manifestations of systemic sclerosis.

Systematic Sclerosis Ulcers Benefit from Hyperbaric Oxygen Treatment

Systematic Sclerosis Ulcers Benefit from Hyperbaric Oxygen Treatment

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Hyperbaric oxygen therapy completely healed 4 patient's systemic sclerosis ulcers.

Systemic Sclerosis Linked to Occupational Heavy Metal Exposure

Systemic Sclerosis Linked to Occupational Heavy Metal Exposure

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Median levels of 24 elements were assessed in patients with systemic sclerosis and matched controls.

Immunosuppressants Effective for Early Diffuse Cutaneous Systemic Sclerosis Treatment

Immunosuppressants Effective for Early Diffuse Cutaneous Systemic Sclerosis Treatment

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Prospective, observational study assessed 4 treatment protocols and their effects on skin thickening.

Raynaud Phenomenon: Revisiting a Cold Weather Problem

Raynaud Phenomenon: Revisiting a Cold Weather Problem

A thorough work-up can differentiate between primary and secondary forms, mitigating progression of a more severe underlying disease.

Efficacy of Open-Label Tocilizumab in Early Systemic Sclerosis

Efficacy of Open-Label Tocilizumab in Early Systemic Sclerosis

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Dinesh Khanna, MD, MSc, discusses results of the open-label portion of a trial evaluating the safety and efficacy of placebo-treated patients with systemic sclerosis who were switched to received open-label tocilizumab.

Emerging Research in Pediatric Localized Scleroderma

Emerging Research in Pediatric Localized Scleroderma

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Sarah Taber, MD, briefly reviews her ongoing research on genetic drivers of localized scleroderma in pediatric patients.

Predictors of Gangrene in Patients With SSc and Digital Ulcers

Predictors of Gangrene in Patients With SSc and Digital Ulcers

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Researchers sought to clarify the rates and risk factors of gangrene formation in patients with SSc utilizing the Digital Ulcer Outcomes Registry.

Decreasing Morbidity Associated With Scleroderma By Addressing Pain Management

Decreasing Morbidity Associated With Scleroderma By Addressing Pain Management

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As part of Scleroderma Awareness Month, physicians specializing in the management of scleroderma discuss mitigating effects of scleroderma-related pain and improving quality of life for their patients.

Ischemic Digital Ulcers Not Reduced by Endothelin-1 Blocker Macitentan in SSc

Ischemic Digital Ulcers Not Reduced by Endothelin-1 Blocker Macitentan in SSc

Treatment with the endothelin-1 blocker macitentan did not reduce the incidence of new digital ulcers over 16 weeks.

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