Spondyloarthritis

Inflammation of Sacroiliac Joint in Axial Spondyloarthritis vs Healthy Participants

Inflammation of Sacroiliac Joint in Axial Spondyloarthritis vs Healthy Participants

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Inflammation shown on MRI of the sacroiliac joint (MRI-SI) is prevalent in axSpA (±30%), but the specificity is not well known.

Abatacept Improves Outcomes in Patients With Active Psoriatic Arthritis

Abatacept Improves Outcomes in Patients With Active Psoriatic Arthritis

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Administration of abatacept may improve patient-reported outcomes in individuals with active psoriatic arthritis and elevated levels of C-reactive protein, irrespective of tumor necrosis factor inhibitor treatment history.

Draft Psoriatic Arthritis Guideline Presented at ACR 2017

Draft Psoriatic Arthritis Guideline Presented at ACR 2017

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The guideline includes recommendations for treating adult patients with active psoriatic arthritis.

Secukinumab Effective for Inhibiting Radiographic Progression in PsA

Secukinumab Effective for Inhibiting Radiographic Progression in PsA

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Regardless of dose, patients taking secukinumab were more likely to experience no radiographic progression compared with placebo.

TNF Inhibitors Decrease Extraarticular Manifestations in Ankylosing Spondylitis

TNF Inhibitors Decrease Extraarticular Manifestations in Ankylosing Spondylitis

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Treatment with TNF inhibitors has led to improvement in physical function and quality of life in patients with ankylosing spondylitis.

Tofacitinib Improves Patient-Reported Outcomes for Active Psoriatic Arthritis

Tofacitinib Improves Patient-Reported Outcomes for Active Psoriatic Arthritis

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Results from phase 3 trials OPAL Broaden (NCT01877668) and OPAL Beyond (NCT01882439) presented at the American College of Rheumatology 2017 in San Diego, California.

Local Inflammation Predicts Structural Damage in Axial Spondyloarthritis

Local Inflammation Predicts Structural Damage in Axial Spondyloarthritis

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Researchers recruited patients with recent onset axial spondyloarthritis and conducted MRI of the spine or MRI of the sacroiliac joints at baseline, 2 years, and 5 years.

Therapeutic Goal Achievement Independent of Cardiovascular Risk in Psoriatic Arthritis

Therapeutic Goal Achievement Independent of Cardiovascular Risk in Psoriatic Arthritis

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With the exception of sedentary lifestyle, cardiovascular risk factors were not found to impact the likelihood of achieving minimal disease activity among patients with psoriatic arthritis.

Higher Prevalence of Depression, ADHD Observed Among Women With Psoriatic Arthritis

Higher Prevalence of Depression, ADHD Observed Among Women With Psoriatic Arthritis

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Researchers observed a higher prevalence of psychiatric disorders among female patients with psoriatic arthritis.

High BMI, Obesity Predict Worse Disease Outcomes in Axial Spondyloarthropathy

High BMI, Obesity Predict Worse Disease Outcomes in Axial Spondyloarthropathy

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Recognition of the negative consequences of being obese is vital to effectively managing axial spondyloarthropathy.

Pregnancy Outcomes in SLE vs Other Connective Tissue, Inflammatory Rheumatic Conditions

Pregnancy Outcomes in SLE vs Other Connective Tissue, Inflammatory Rheumatic Conditions

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Real-world data indicate that although most patients with systemic lupus erythematosus or connective tissue diseases have successful pregnancies, more adverse pregnancy outcomes occur.

Long-Term Safety of Adalimumab in Immune-Related Diseases Analyzed

Long-Term Safety of Adalimumab in Immune-Related Diseases Analyzed

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Investigators sought to determine the long-term safety of adalimumab use in patients with arthritis and other immune-related diseases.

Biomarkers of Peripheral and Axial Arthritis in Psoriatic Disease

Biomarkers of Peripheral and Axial Arthritis in Psoriatic Disease

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Study confirms the validity of previously identified bone-turnover biomarkers for psoriatic disease-associated arthritis and for axial arthritis.

Etanercept May Slow Radiographic Sacroiliac Joint Progression in Axial Spondyloarthritis

Etanercept May Slow Radiographic Sacroiliac Joint Progression in Axial Spondyloarthritis

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In patients with recent-onset axial spondyloarthritis (axSpA), the long-term use of etanercept may result in a lower rate of radiographic progression in the sacroiliac joint.

TNF Blockers and Reduced Spinal Radiographic Progression in Ankylosing Spondylitis

TNF Blockers and Reduced Spinal Radiographic Progression in Ankylosing Spondylitis

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TNFi therapy in ankylosing spondylitis has a clinically relevant inhibitory effect on spinal radiographic progression.

Psoriatic Arthritits Patients Maintain Clinical Improvement With Long-Term Secukinumab

Psoriatic Arthritits Patients Maintain Clinical Improvement With Long-Term Secukinumab

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Results from the FUTURE 2 study show that secukinumab improves signs and symptoms in patients with active psoriatic arthritis through 2 years of therapy.

Predictors of Accelerated Atherosclerosis in Spondyloarthritis Without Overt CVD

Predictors of Accelerated Atherosclerosis in Spondyloarthritis Without Overt CVD

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Predictors of subclinical accelerated atherosclerosis were examined in a recent study of patients with spondyloarthritis without overt cardiovascular disease.

Real-World Data Validates Minimal Disease Activity Index in PsA

Real-World Data Validates Minimal Disease Activity Index in PsA

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Overall improvements in rates of minimal disease activity are achieved in patients with PsA when they are treated with anti-tumor necrosis factor agents

Sonographic Enthesitis as a Potential Marker of Radiographic Damage Severity in PsA

Sonographic Enthesitis as a Potential Marker of Radiographic Damage Severity in PsA

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The association between sonographic enthesitis and severity of radiographic features of peripheral and axial joint damage in psoriatic arthritis was examined in a cross-sectional study.

Nonradiographic Axial Spondyloarthritis May Be Revealed by MRI

Nonradiographic Axial Spondyloarthritis May Be Revealed by MRI

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A study analyzes whether underlying sacroiliac erosions may be present in patients with nonradiographic axial spondylarthritis who have normal radiographs.

Ultrasound-Detected Synovitis Predicts Short-term PsA Disease Flare

Ultrasound-Detected Synovitis Predicts Short-term PsA Disease Flare

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The ability of Power Doppler Ultrasound to predict short-term psoriatic arthritis disease flare was investigated in a new study.

Markers of Radiographic Spinal Progression in Ankylosing Spondylitis

Markers of Radiographic Spinal Progression in Ankylosing Spondylitis

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Serum leptin and high molecular weight adiponectin have an inverse relationship with radiographic spinal progression in patients with ankylosing spondylitis.

Early Predictors of Poor Long-Term Treatment Response in Spondyloarthritis

Early Predictors of Poor Long-Term Treatment Response in Spondyloarthritis

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Determining which patients are unlikely to respond to therapy early on may help reduce unnecessary treatment and contain costs.

Guidelines for Peri-Op Care in Rheumatic Disease

Guidelines for Peri-Op Care in Rheumatic Disease

These guidelines address the use of antirheumatic drugs for adults with RA, SpA, JIA, and SLE undergoing THA or TKA.

Risk for Endocrine Comorbidities Increased in Psoriatic Arthritis

Risk for Endocrine Comorbidities Increased in Psoriatic Arthritis

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Researchers evaluated the prevalence of several endocrine disorders in patients with psoriatic arthritis.

GRAPPA-OMERACT: PsA Outcomes Measures Updated for Greater Inclusion of Patient Concerns

GRAPPA-OMERACT: PsA Outcomes Measures Updated for Greater Inclusion of Patient Concerns

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The domains for outcome measurement in clinical trials of psoriatic arthritis were updated by the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis and endorsed by Outcome Measures in Rheumatology.

GRAPPA-OMERACT: Updated PsA Outcomes Measures Offer Greater Inclusion of Patient Concerns

GRAPPA-OMERACT: Updated PsA Outcomes Measures Offer Greater Inclusion of Patient Concerns

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The domains for outcome measurement in clinical trials of psoriatic arthritis were updated by the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis and endorsed by Outcome Measures in Rheumatology.

Infliximab Biosimilar Now FDA Approved for RA, PsA, AS

Infliximab Biosimilar Now FDA Approved for RA, PsA, AS

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Renflexis is a TNF blocker indicated for Crohn's disease, pediatric Crohn's disease, ulcerative colitis, rheumatoid arthritis in combination with methotrexate, ankylosing spondylitis, psoriatric arthritis, and plaque psoriasis.

Biosimilar Confidence: Physician-Patient Communication Sets the Tone

Biosimilar Confidence: Physician-Patient Communication Sets the Tone

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Jonathan Krant, MD, FACP, confronts the issues surrounding biosimilar substitution for biologic treatments.

Women Have Lower Psoriasis Area and Severity Index Scores Than Men

Women Have Lower Psoriasis Area and Severity Index Scores Than Men

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Women were found to have a lower median of scores in the Psoriasis Area and Severity Index than men.

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