Systemic lupus erythematosus (SLE)

Complement Pathway Activation Linked to Adverse Pregnancy Outcomes in Women With SLE

Complement Pathway Activation Linked to Adverse Pregnancy Outcomes in Women With SLE

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Complement pathway activation is associated with adverse pregnancy outcomes in women with systemic lupus erythematosus or antiphospholipid antibodies.

Lupus and Pregnancy: Counseling Strategies to Ensure Optimal Outcomes

Lupus and Pregnancy: Counseling Strategies to Ensure Optimal Outcomes

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Advances in the management of systemic lupus erythematosus have improved quality of life and outcomes for women who are considering pregnancy.

Smoking Status Linked to Risk for Anti-Double Stranded DNA SLE Subtype

Smoking Status Linked to Risk for Anti-Double Stranded DNA SLE Subtype

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Smoking is associated with risk for development of the anti-double-stranded DNA positive subtype of systemic lupus erythematosus.

Effects of Cerebrovascular Morbidity on Quality of Life in SLE

Effects of Cerebrovascular Morbidity on Quality of Life in SLE

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The frequency, attribution, clinical, and autoantibody status of patients with lupus who developed cerebrovascular events are reported in this study.

Does SLE Increase the Risk for Perioperative Major Adverse Cardiovascular Events?

Does SLE Increase the Risk for Perioperative Major Adverse Cardiovascular Events?

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Future research should look to improve perioperative management in people with systemic lupus erythematosus.

Nitrated Nucleosome Levels Linked to Neuropsychiatric Events in Systemic Lupus Erythematosus

Nitrated Nucleosome Levels Linked to Neuropsychiatric Events in Systemic Lupus Erythematosus

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At this time, no serological test can distinguish neuropsychiatric events resulting from SLE activity from events resulting from other causes.

Association Between Maternal Systemic Lupus Erythematosus and Asthma in Offspring

Association Between Maternal Systemic Lupus Erythematosus and Asthma in Offspring

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The risk for asthma may be increased in children born to mothers with systemic lupus erythematosus during pregnancy.

EULAR/ACR Systemic Lupus Erythematosus Classification Criteria Update

EULAR/ACR Systemic Lupus Erythematosus Classification Criteria Update

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EULAR and ACR jointly funded and collaborated on creating a set of criteria that can be used to more accurately identify patients with SLE for inclusion in clinical trials.

Smoking May Be Linked to Pathogenesis of Anti-double Stranded DNA in SLE

Smoking May Be Linked to Pathogenesis of Anti-double Stranded DNA in SLE

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Current smoking and >10 pack-years of smoking have demonstrated a strong and specific association with an increased risk for occurrence of anti-double-stranded DNA systemic lupus erythematosus.

In SLE, Medication Non-Adherence, Depression Are Prevalent

In SLE, Medication Non-Adherence, Depression Are Prevalent

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In patients with SLE, 62.1% did not adhere to their medication regimens and 35% of patients demonstrated a depressed mood.

Trauma Associated With Incident Systemic Lupus Erythematosus in Women

Trauma Associated With Incident Systemic Lupus Erythematosus in Women

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Identification of the biologic pathways by which psychosocial trauma may increase a woman's risk for autoimmune disorders is critical and may offer greater insight into disease etiology and strategies for prevention.

Drug-Induced Lupus Erythematosus: Clinical Presentation and Differential Diagnosis

Drug-Induced Lupus Erythematosus: Clinical Presentation and Differential Diagnosis

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Drug-induced lupus erythematosus refers to an idiosyncratic side effect of medications with clinical features similar to the autoimmune-driven idiopathic lupus erythematosus.

Comprehensive Methods Work to Determine SLE Incidence and Prevalence

Comprehensive Methods Work to Determine SLE Incidence and Prevalence

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Research confirmed the increased burden of SLE in black, Asian, and Hispanic women compared with white women.

Hydroxychloroquine Plus Low-Dose Aspirin Reduces Cardiovascular Events in Systemic Lupus Erythematosus

Hydroxychloroquine Plus Low-Dose Aspirin Reduces Cardiovascular Events in Systemic Lupus Erythematosus

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Long-term hydroxychloroquine use, combined with low-dose aspirin, protected against thrombosis in patients with systemic lupus erythematosus.

Diffuse Alveolar Hemorrhage in SLE Associated With Serious Disease Flare

Diffuse Alveolar Hemorrhage in SLE Associated With Serious Disease Flare

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This condition is associated with serious disease flare complicated by sepsis and a high mortality rate.

SLE Patients With Lupus Nephritis Have Higher Cardiovascular Event Risk

SLE Patients With Lupus Nephritis Have Higher Cardiovascular Event Risk

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Lupus nephritis a risk factor for some, but not all, cardiovascular outcomes in study of patients with SLE.

Efficacy of Influenza Vaccination in Adults With SLE

Efficacy of Influenza Vaccination in Adults With SLE

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Influenza vaccination reduced risk of hospitalization, pneumonia, ICU admission, in-hospital dialysis, and death.

RCT: Mind-Body Training Improves Depressive Symptoms in SLE

RCT: Mind-Body Training Improves Depressive Symptoms in SLE

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A randomized-control trial found that mind-body skills training improved depressive symptoms in patients with SLE.

Algorithmic Intervention Improves Access to SLE Specialty Care

Algorithmic Intervention Improves Access to SLE Specialty Care

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The institution of an algorithmic approach to diagnostic testing for SLE improved access to specialty care in a safety net system providing health care to the underserved.

FDA Issues PPI Classwide Warning for CLE, SLE

FDA Issues PPI Classwide Warning for CLE, SLE

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The US FDA has approved an update to the prescribing information for all proton pump inhibitors to include risk for cutaneous and systemic lupus erythematosus.

Amylase-Trypsin Inhibitors and Systemic Inflammation

Amylase-Trypsin Inhibitors and Systemic Inflammation

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Amylase-trypsin inhibitors (ATIs) found in wheat have been linked to inflammation in the lymph nodes, kidneys, spleen, and brain, and can worsen symptoms of RA, SLE, and MS.

Evaluating Necessity of Valvular Heart Disease Screening in SLE

Evaluating Necessity of Valvular Heart Disease Screening in SLE

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The researchers confirm a relatively high prevalence of significant VHD among patients with SLE and a confirmed association between VHD and aPL positivity.

Targeted IL-6 Inhibition With Sirukumab Ineffective in Lupus Nephritis

Targeted IL-6 Inhibition With Sirukumab Ineffective in Lupus Nephritis

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Targeted IL-6 inhibition with sirukumab did not demonstrate efficacy or acceptable safety in patients with active lupus nephritis concomitantly receiving immunosupprsant therapy.

SLE Pregnancy Outcomes Impacted by Maternal Race, Ethnicity

SLE Pregnancy Outcomes Impacted by Maternal Race, Ethnicity

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Researchers found significant disparities in pregnancy complications rates and hospitalization costs among white, black, and Hispanic women with systemic lupus erythematosus

Applying Precision Medicine to Systemic Lupus Erythematosus

Applying Precision Medicine to Systemic Lupus Erythematosus

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Clinicians and researchers weigh in on the advent of precision medicine for the treatment of SLE.

Mechanisms Behind Co-existence of Celiac Disease With SLE

Mechanisms Behind Co-existence of Celiac Disease With SLE

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Analysis of medical records confirms that celiac disease frequently co-occurs with SLE.

<i> S aureus </i> Nasal Colonization Associated With SLE Disease Phenotype

S aureus Nasal Colonization Associated With SLE Disease Phenotype

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S aureus colonization was associated with particular SLE phenotypes.

Is There Evidence to Support Serial aPL Testing in Pregnant Women?

Is There Evidence to Support Serial aPL Testing in Pregnant Women?

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Although levels of aPL decreased throughout pregnancy, these changes were not found to be associated with changes in adverse pregnancy outcomes.

Baseline Biomarkers Predictive of Tx Response to Atacicept in SLE

Baseline Biomarkers Predictive of Tx Response to Atacicept in SLE

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New study investigates links between elevated BLyS and APRIL levels and response to atacicept treatment.

Improving Sensitivity of LN Urinary Markers by Combining Panels

Improving Sensitivity of LN Urinary Markers by Combining Panels

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Panels of urinary biomarkers were shown to be have increased diagnostic power in predicting complete clinical responses when compared with individual biomarkers.

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