Systemic lupus erythematosus (SLE)

EULAR/ACR Systemic Lupus Erythematosus Classification Criteria Update

EULAR/ACR Systemic Lupus Erythematosus Classification Criteria Update

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EULAR and ACR jointly funded and collaborated on creating a set of criteria that can be used to more accurately identify patients with SLE for inclusion in clinical trials.

Smoking May Be Linked to Pathogenesis of Anti-double Stranded DNA in SLE

Smoking May Be Linked to Pathogenesis of Anti-double Stranded DNA in SLE

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Current smoking and >10 pack-years of smoking have demonstrated a strong and specific association with an increased risk for occurrence of anti-double-stranded DNA systemic lupus erythematosus.

In SLE, Medication Non-Adherence, Depression Are Prevalent

In SLE, Medication Non-Adherence, Depression Are Prevalent

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In patients with SLE, 62.1% did not adhere to their medication regimens and 35% of patients demonstrated a depressed mood.

Trauma Associated With Incident Systemic Lupus Erythematosus in Women

Trauma Associated With Incident Systemic Lupus Erythematosus in Women

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Identification of the biologic pathways by which psychosocial trauma may increase a woman's risk for autoimmune disorders is critical and may offer greater insight into disease etiology and strategies for prevention.

Drug-Induced Lupus Erythematosus: Clinical Presentation and Differential Diagnosis

Drug-Induced Lupus Erythematosus: Clinical Presentation and Differential Diagnosis

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Drug-induced lupus erythematosus refers to an idiosyncratic side effect of medications with clinical features similar to the autoimmune-driven idiopathic lupus erythematosus.

Comprehensive Methods Work to Determine SLE Incidence and Prevalence

Comprehensive Methods Work to Determine SLE Incidence and Prevalence

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Research confirmed the increased burden of SLE in black, Asian, and Hispanic women compared with white women.

Hydroxychloroquine Plus Low-Dose Aspirin Reduces Cardiovascular Events in Systemic Lupus Erythematosus

Hydroxychloroquine Plus Low-Dose Aspirin Reduces Cardiovascular Events in Systemic Lupus Erythematosus

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Long-term hydroxychloroquine use, combined with low-dose aspirin, protected against thrombosis in patients with systemic lupus erythematosus.

Diffuse Alveolar Hemorrhage in SLE Associated With Serious Disease Flare

Diffuse Alveolar Hemorrhage in SLE Associated With Serious Disease Flare

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This condition is associated with serious disease flare complicated by sepsis and a high mortality rate.

SLE Patients With Lupus Nephritis Have Higher Cardiovascular Event Risk

SLE Patients With Lupus Nephritis Have Higher Cardiovascular Event Risk

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Lupus nephritis a risk factor for some, but not all, cardiovascular outcomes in study of patients with SLE.

Efficacy of Influenza Vaccination in Adults With SLE

Efficacy of Influenza Vaccination in Adults With SLE

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Influenza vaccination reduced risk of hospitalization, pneumonia, ICU admission, in-hospital dialysis, and death.

RCT: Mind-Body Training Improves Depressive Symptoms in SLE

RCT: Mind-Body Training Improves Depressive Symptoms in SLE

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A randomized-control trial found that mind-body skills training improved depressive symptoms in patients with SLE.

Algorithmic Intervention Improves Access to SLE Specialty Care

Algorithmic Intervention Improves Access to SLE Specialty Care

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The institution of an algorithmic approach to diagnostic testing for SLE improved access to specialty care in a safety net system providing health care to the underserved.

FDA Issues PPI Classwide Warning for CLE, SLE

FDA Issues PPI Classwide Warning for CLE, SLE

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The US FDA has approved an update to the prescribing information for all proton pump inhibitors to include risk for cutaneous and systemic lupus erythematosus.

Amylase-Trypsin Inhibitors and Systemic Inflammation

Amylase-Trypsin Inhibitors and Systemic Inflammation

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Amylase-trypsin inhibitors (ATIs) found in wheat have been linked to inflammation in the lymph nodes, kidneys, spleen, and brain, and can worsen symptoms of RA, SLE, and MS.

Evaluating Necessity of Valvular Heart Disease Screening in SLE

Evaluating Necessity of Valvular Heart Disease Screening in SLE

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The researchers confirm a relatively high prevalence of significant VHD among patients with SLE and a confirmed association between VHD and aPL positivity.

Targeted IL-6 Inhibition With Sirukumab Ineffective in Lupus Nephritis

Targeted IL-6 Inhibition With Sirukumab Ineffective in Lupus Nephritis

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Targeted IL-6 inhibition with sirukumab did not demonstrate efficacy or acceptable safety in patients with active lupus nephritis concomitantly receiving immunosupprsant therapy.

SLE Pregnancy Outcomes Impacted by Maternal Race, Ethnicity

SLE Pregnancy Outcomes Impacted by Maternal Race, Ethnicity

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Researchers found significant disparities in pregnancy complications rates and hospitalization costs among white, black, and Hispanic women with systemic lupus erythematosus

Applying Precision Medicine to Systemic Lupus Erythematosus

Applying Precision Medicine to Systemic Lupus Erythematosus

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Clinicians and researchers weigh in on the advent of precision medicine for the treatment of SLE.

Mechanisms Behind Co-existence of Celiac Disease With SLE

Mechanisms Behind Co-existence of Celiac Disease With SLE

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Analysis of medical records confirms that celiac disease frequently co-occurs with SLE.

<i> S aureus </i> Nasal Colonization Associated With SLE Disease Phenotype

S aureus Nasal Colonization Associated With SLE Disease Phenotype

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S aureus colonization was associated with particular SLE phenotypes.

Is There Evidence to Support Serial aPL Testing in Pregnant Women?

Is There Evidence to Support Serial aPL Testing in Pregnant Women?

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Although levels of aPL decreased throughout pregnancy, these changes were not found to be associated with changes in adverse pregnancy outcomes.

Baseline Biomarkers Predictive of Tx Response to Atacicept in SLE

Baseline Biomarkers Predictive of Tx Response to Atacicept in SLE

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New study investigates links between elevated BLyS and APRIL levels and response to atacicept treatment.

Improving Sensitivity of LN Urinary Markers by Combining Panels

Improving Sensitivity of LN Urinary Markers by Combining Panels

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Panels of urinary biomarkers were shown to be have increased diagnostic power in predicting complete clinical responses when compared with individual biomarkers.

Effect Modifications Between 25[OH]D and Related Genes on SLE Risk

Effect Modifications Between 25[OH]D and Related Genes on SLE Risk

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CYP24A1, a gene involved in physiologically active 1,25[OH]2D degradation appears to play an important role in the association of lower levels of 25[OH]D and increased risk of SLE

Serum IgG Levels Associated With Prognosis in SLE-AIH

Serum IgG Levels Associated With Prognosis in SLE-AIH

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Features distinguishing SLE-AIH from primary AIH were examined by researchers in an effort to improve treatment responses and prognosis

SLE Renal Outcomes With Mixed LN and Pure Proliferative LN Compared

SLE Renal Outcomes With Mixed LN and Pure Proliferative LN Compared

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The association between mixed proliferative lupus nephritis (MPLN), pure proliferative lupus nephritis (PPLN), and short-term renal outcomes was examined in new research.

Air Particulate Exposure Associated With Pediatric Lupus Activity

Air Particulate Exposure Associated With Pediatric Lupus Activity

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Exposure to certain fine particulate matter in air pollution was associated with increased severity of lupus disease activity in pediatric patients

Perceived Physical, Social Limitations of Young Adults With SLE

Perceived Physical, Social Limitations of Young Adults With SLE

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In this cohort, young patients with SLE perceived self-limited physical and social capacities

New IFN-α Monoclonal Antibody Effective in Moderate to Severe SLE

New IFN-α Monoclonal Antibody Effective in Moderate to Severe SLE

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A greater percentage of patients who received sifalimumab achieved an SLE responder index response at week 52 compared with placebo.

Increased Risk of Myocardial Infarction in SLE Patients Prior to Diagnosis

Increased Risk of Myocardial Infarction in SLE Patients Prior to Diagnosis

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Few studies have examined the rate of cardiac events occurring either prior to SLE or early in the course of disease.

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