Addressing Racial Disparities in Systemic Lupus Erythematosus Treatment

Racial disparities have been observed in the disease course and outcomes of African Americans with SLE compared with white patients with SLE.

Expert Insight: Using Infodemiology to Fill Knowledge Gaps in SLE

Infodemiology can estimate the health-related demands and behaviors of systemic lupus erythematosus.

Lupus and Pregnancy: Counseling Strategies to Ensure Optimal Outcomes

Advances in the management of systemic lupus erythematosus have improved quality of life and outcomes for women who are considering pregnancy.

Neonatal Lupus: Clinical Manifestations and Treatment Options

Neonatal systemic lupus erythematosus syndrome develops as a result of passively acquired autoimmunity, when autoantibodies produced by the mother cross the placenta, affecting the developing ...

Identifying SLE-Related Health Demands Using Data Mining, Big Data

"Infodemiology" and "infoveillance" are terms used to describe an emerging approach to public health research, based on Google Trends big data monitoring and data mining.

Unmet Needs in the Pathogenesis, Treatment of Systemic Lupus Erythematosus

Improved survival has ushered in new challenges that inadvertently increase the risk for death in patients with SLE.

Cardiovascular Disease Risk in Patients With Systemic Lupus Erythematosus

Improved treatment in SLE with increased life expectancy has been accompanied by an elevated risk for developing cardiovascular diseases.

Drug-Induced Lupus Erythematosus: Clinical Presentation and Differential Diagnosis

Drug-induced lupus erythematosus refers to an idiosyncratic side effect of medications with clinical features similar to the autoimmune-driven idiopathic lupus erythematosus.

Advancing Understanding of Shrinking Lung Syndrome in SLE

The diagnosis and management of shrinking lung syndrome, a rare complication of systemic lupus erythematosus, is discussed in a comprehensive review.

Optimal ANA Cutoff Titer as Entry Criterion for SLE Classification

The new approach in development proposes the use of positive indirect immunofluorescence ANA (IIF-ANA) as an entry criterion for SLE classification.

Latest News

Quality of SLE Care Assessed in Specialized Lupus vs General Rheumatology Clinic

Quality of SLE Care Assessed in Specialized Lupus vs General Rheumatology Clinic

Researchers compared the quality of care received by patients with systemic lupus erythematosus in 2 settings within the same academic institution.

Genetic Risk Loci Found Within Disease Phenotypes Including SLE, JIA

Genetic Risk Loci Found Within Disease Phenotypes Including SLE, JIA

The Epstein-Barr virus EBNA2 protein and many coclustering human transcription factors occupied nearly half of SLE risk loci.

Metabolic Syndrome Frequency Assessed in Systemic Lupus Erythematosus

Metabolic Syndrome Frequency Assessed in Systemic Lupus Erythematosus

The frequency of metabolic syndrome among patients with SLE was approximately 45%.

Efficacy of Blisibimod Therapy Evaluated in Systemic Lupus Erythematosus

Efficacy of Blisibimod Therapy Evaluated in Systemic Lupus Erythematosus

Blisibimod was effective in patients with SLE in terms of steroid reduction, decreased proteinuria, and improvement in serological markers.

Ubiquitination in NETs May Affect Adaptive Immune Responses in SLE

Ubiquitination in NETs May Affect Adaptive Immune Responses in SLE

Neutrophil extracellular traps contain ubiquitinated proteins with a lower expression of polyubiquitinated proteins in patients with SLE.

Women With SLE Become Pregnant More Easily vs Women With Rheumatoid Arthritis

Women With SLE Become Pregnant More Easily vs Women With Rheumatoid Arthritis

Researchers examined differences in the ability to get pregnant in women with systemic lupus erythematosus and rheumatoid arthritis.

Ofatumumab Safe, Effective for B Cell Depletion in Rituximab-Intolerant SLE

Ofatumumab Safe, Effective for B Cell Depletion in Rituximab-Intolerant SLE

Ofatumumab was a well-tolerated, safe, and effective alternative to rituximab for B cell depletion therapy.

Novel Gene Variants Associated With CVD Identified in Patients With SLE and RA

Novel Gene Variants Associated With CVD Identified in Patients With SLE and RA

The IL-19 risk allele is associated with stroke and myocardial infarction in patients with systemic lupus erythematosus and rheumatoid arthritis, but not in the general population.

Examining Remission Status as a Predictor of Long-Term Renal Survival in Lupus Nephritis

Examining Remission Status as a Predictor of Long-Term Renal Survival in Lupus Nephritis

Remission status was a significant and useful predictor of renal survival, in patients with lupus nephritis.

Autoimmune Reactivity to Malondialdehyde in SLE Linked to High Disease Activity, Lupus Nephritis

Autoimmune Reactivity to Malondialdehyde in SLE Linked to High Disease Activity, Lupus Nephritis

Researchers investigated serum IgG anti-MDA expression and associations with disease activity in patients with systemic lupus erythematosus.

Examining Lupus Low Disease Activity State as an SLE Outcome Measure

Examining Lupus Low Disease Activity State as an SLE Outcome Measure

Results from the MUSE trial show that lupus low disease activity state attainment in patients with systemic lupus erythematosus is a clinically meaningful disease outcome measure.

Higher Rate of Atrial Fibrillation in Men With Systemic Lupus Erythematosus

Higher Rate of Atrial Fibrillation in Men With Systemic Lupus Erythematosus

Researchers used phenotype-wide association studies to uncover associations in men and women with systemic lupus erythematosus.

Systemic Lupus Erythematosus Disease Flares Increase During, Shortly After Pregnancy

Systemic Lupus Erythematosus Disease Flares Increase During, Shortly After Pregnancy

Researchers found that disease flare incidence in women with SLE increased during pregnancy and within 3 months postpartum.

Mortality, ESRD Incidence Measured in Men vs Women With Lupus Nephritis

Mortality, ESRD Incidence Measured in Men vs Women With Lupus Nephritis

No significant differences were observed in the incidence of ESRD and mortality among men vs women with lupus nephritis.

Childhood-Onset SLE Often Results in Damage to Several Organ Systems

Childhood-Onset SLE Often Results in Damage to Several Organ Systems

Disease damage in patients with childhood-onset SLE is common, even with relatively short disease durations.

Epratuzumab in SLE With Associated Sjogren Syndrome Improved SLE Disease Activity

Epratuzumab in SLE With Associated Sjogren Syndrome Improved SLE Disease Activity

Epratuzumab improved systemic lupus erythematosus disease activity in patients with associated Sjogren syndrome.

Few SLE Patients Receive Retinal Examinations With Hydroxychloroquine Initiation

Few SLE Patients Receive Retinal Examinations With Hydroxychloroquine Initiation

Researchers examined the proportion of Medicaid patients with systemic lupus erythematosus who receive baseline retinal examinations when initiating treatment with hydroxychloroquine.

Short-Form Patient-Reported Outcomes Tool Effective in SLE

Short-Form Patient-Reported Outcomes Tool Effective in SLE

The PROMIS10 patient-reported outcome measure is a valid and reliable tool in routine systemic lupus erythematosus care.

Raynaud Phenomenon, Migraine Linked to aPS/PT Antibodies in Primary Antiphospholipid Syndrome

Raynaud Phenomenon, Migraine Linked to aPS/PT Antibodies in Primary Antiphospholipid Syndrome

In patients with primary antiphospholipid syndrome, the presence of phosphatidylserine/prothrombin complex antibodies is associated with Raynaud phenomenon and migraine.

Complement Pathway Activation Linked to Adverse Pregnancy Outcomes in Women With SLE

Complement Pathway Activation Linked to Adverse Pregnancy Outcomes in Women With SLE

Complement pathway activation is associated with adverse pregnancy outcomes in women with systemic lupus erythematosus or antiphospholipid antibodies.

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