Optimal ANA Cutoff Titer as Entry Criterion for SLE Classification

The new approach in development proposes the use of positive indirect immunofluorescence ANA (IIF-ANA) as an entry criterion for SLE classification.

Lymphoma in Patients With Systemic Lupus Erythematosus: Expert Insights

In this expert interview, Sasha Bernatsky, MD, PhD, and Michelle Petri, MD, MPH, discuss the risk of non-Hodgkin lymphoma in SLE.

Lupus: Using Diet and Nutrition to Improve Symptoms and Outcomes

Consuming adequate amounts of the right nutrients, and limiting others, can help relieve symptoms and improve outcomes in patients with systemic lupus erythematosus.

Applying Precision Medicine to Systemic Lupus Erythematosus

Clinicians and researchers weigh in on the advent of precision medicine for the treatment of SLE.

EULAR Updates Recommendations for Reproductive Planning in SLE

Multidisciplinary experts provide 12 recommendations for the planning and management of pregnancy in systemic lupus erythematosus and/or antiphospholipid syndrome.

Case Study and Clinical Highlight: Respiratory Failure in a Patient With SLE

A female patient with systemic lupus erythematosus presents to the emergency department with an 8 week history of dyspnea, dysphonia, and non-productive cough.

Allograft Survival After Renal Transplantation for Lupus Nephritis

Transplantation is a suitable option for some patients with end-stage renal disease associated with lupus nephritis after careful consideration of several factors.

Revisiting SLE-Related Intestinal Pseudo-Obstruction

Intestinal pseudo-obstruction has been considered a rare complication of SLE, but the condition has not been well defined, with most information coming from case reports.

Can Pharmacogenetics and Precision Medicine Change the Future of SLE Diagnosis and Treatment?

New research may help clinicians better identify individuals with the greatest risk for specific clinical disease features of SLE.

Renal Biopsy: Impact on Diagnosis, Prognosis, and Clinical Decision Making in Lupus Nephritis

Although renal biopsy is relatively safe and serious complications are uncommon, the risk of bleeding and other adverse events remains a key concern.

Latest News

Diffuse Alveolar Hemorrhage in SLE Associated With Serious Disease Flare

Diffuse Alveolar Hemorrhage in SLE Associated With Serious Disease Flare

This condition is associated with serious disease flare complicated by sepsis and a high mortality rate.

Risk Factors for Depression in Patients With Childhood-Onset Lupus

Risk Factors for Depression in Patients With Childhood-Onset Lupus

Increased disease activity, poorer physical functioning, and lower education attainment were major predictors for depression in adulthood.

Biomarkers of Pulmonary Arterial Hypertension Risk in SLE

Biomarkers of Pulmonary Arterial Hypertension Risk in SLE

Meta-analysis supports anti-RNP and anti-Sm antibodies as serological biomarkers of PAH risk in patients with systemic lupus erythematosus.

Patients With Systemic Lupus Erythematosus and Cognitive Dysfunction Prevalence

Patients With Systemic Lupus Erythematosus and Cognitive Dysfunction Prevalence

MOCA is more effective than the Mini-Mental State Examination at detecting cognitive dysfunction.

Patients With Lupus Have Poor Quality of Sleep, Quality of Life

Patients With Lupus Have Poor Quality of Sleep, Quality of Life

The majority of patients with systemic lupus erythematosus have poor quality of sleep.

Steroid Dosage as Risk Factor for Osteonecrosis in Patients With SLE

Steroid Dosage as Risk Factor for Osteonecrosis in Patients With SLE

Cumulative steroid dosage is a risk factor for the development of osteonecrosis.

SLE in Mothers May Lead to Increased Allergy Risk in Offspring

SLE in Mothers May Lead to Increased Allergy Risk in Offspring

There is an increased risk of allergic conditions in the offspring of mothers with SLE.

Belimumab for SLE: Is Subcutaneous Delivery As Effective as Infusion?

Belimumab for SLE: Is Subcutaneous Delivery As Effective as Infusion?

As intravenous infusion can pose challenges to patients, the current study sought to evaluate the efficacy of subcutaneous belimumab.

Genetic Variant Tied to SLE and MS Identified

Genetic Variant Tied to SLE and MS Identified

BAFF variant was likely selected over time as an adaptive response to malaria.

International Panel Releases Guidelines for Biologics Use in Lupus

International Panel Releases Guidelines for Biologics Use in Lupus

The guidelines were established by a mutidisciplinary group of experts with a goal of optimizing lupus outcomes for all patients.

Relative Risk of Ischemic Stroke Doubled in Systemic Lupus Erythematosus

Relative Risk of Ischemic Stroke Doubled in Systemic Lupus Erythematosus

A matched cohort study compared the risk of incident stroke in individuals with SLE with individuals without SLE in the general population.

Lupus Low-disease Activity State Can Predict Flare-up Risk

Lupus Low-disease Activity State Can Predict Flare-up Risk

Asia-Pacific Lupus Collaborative's low-disease activity score can predict risk of flare-ups, according to research from a group at Hong Kong University.

Reduced Lupus Risk Linked to Moderate Alcohol Consumption in Women

Reduced Lupus Risk Linked to Moderate Alcohol Consumption in Women

The study evaluated 2 groups of women from the Nurses' Health Study (NHS) and NHSII cohorts, examining alcohol consumption and the onset of systemic lupus erythematosus.

Systemic Lupus Erythematosus Leads to Lower Quality-of-Life Measures

Systemic Lupus Erythematosus Leads to Lower Quality-of-Life Measures

Study of patients with systemic lupus erythematosus in China evaluates quality of life measures in several areas.

Reduced Psychosocial Reserve Linked to Increased SLE Disease Burden

Reduced Psychosocial Reserve Linked to Increased SLE Disease Burden

Patients with systemic lupus erythematosus and low self-esteem reported higher levels of anxiety and depression.

Elevated Disease Markers Identified in Relatives of Patients With Lupus

Elevated Disease Markers Identified in Relatives of Patients With Lupus

Changes in levels of soluble mediators may predict SLE transition in unaffected relatives of patients.

Lupus Family Planning Recommendations Issued by EULAR

Lupus Family Planning Recommendations Issued by EULAR

A European League Against Rheumatism writing committee has issued recommendations for family planning for women with systemic lupus erythematosus and antiphospholipid syndrome based on a systemic review.

Adults With Lupus More Likely to Have Depression and Anxiety

Adults With Lupus More Likely to Have Depression and Anxiety

The researchers conducted a systematic review of data from 59 studies.

Immunosuppressants Effective for Early Diffuse Cutaneous Systemic Sclerosis Treatment

Immunosuppressants Effective for Early Diffuse Cutaneous Systemic Sclerosis Treatment

Prospective, observational study assessed 4 treatment protocols and their effects on skin thickening.

Researchers Examine Potential Key to Future Lupus Treatments

Researchers Examine Potential Key to Future Lupus Treatments

Research examined virus-independent activation of MAVS protein in patients with systemic lupus erythematosus.

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