Managing Cognitive Dysfunction in Systemic Lupus Erythematosus

The pathogenic pathways of SLE-related cognitive dysfunction are yet to be fully elucidated, but vasculopathy, antibody-mediated neurotoxicity, impairments in cytokine signaling, and complement abnormalities have ...

PAH-Associated Connective Tissue Diseases: A Case for Separating SSc, SLE

Recent evidence suggests that systemic sclerosis and SLE in pulmonary arterial hypertension should be considered separate diseases.

Clinician Roundtable: Improving Quality of Life in Systemic Lupus Erythematosus

Quality of life measurements capture unique information about systemic lupus erythematosus that are not included in disease activity or damage evaluations.

Addressing Racial Disparities in Systemic Lupus Erythematosus Treatment

Racial disparities have been observed in the disease course and outcomes of African Americans with SLE compared with white patients with SLE.

Expert Insight: Using Infodemiology to Fill Knowledge Gaps in SLE

Infodemiology can estimate the health-related demands and behaviors of systemic lupus erythematosus.

Lupus and Pregnancy: Counseling Strategies to Ensure Optimal Outcomes

Advances in the management of systemic lupus erythematosus have improved quality of life and outcomes for women who are considering pregnancy.

Neonatal Lupus: Clinical Manifestations and Treatment Options

Neonatal systemic lupus erythematosus syndrome develops as a result of passively acquired autoimmunity, when autoantibodies produced by the mother cross the placenta, affecting the developing ...

Identifying SLE-Related Health Demands Using Data Mining, Big Data

"Infodemiology" and "infoveillance" are terms used to describe an emerging approach to public health research, based on Google Trends big data monitoring and data mining.

Unmet Needs in the Pathogenesis, Treatment of Systemic Lupus Erythematosus

Improved survival has ushered in new challenges that inadvertently increase the risk for death in patients with SLE.

Cardiovascular Disease Risk in Patients With Systemic Lupus Erythematosus

Improved treatment in SLE with increased life expectancy has been accompanied by an elevated risk for developing cardiovascular diseases.

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Examining the Prevalence, Characteristics of Monophasic Disease Course in SLE

Examining the Prevalence, Characteristics of Monophasic Disease Course in SLE

Researchers sought to assess the prevalence and characteristics of monophasic disease course in a defined cohort of patients with SLE.

Comparing Factors Associated With Tubulointerstitial Inflammation in Lupus Nephritis

Comparing Factors Associated With Tubulointerstitial Inflammation in Lupus Nephritis

Routinely available serologic markers have no correlation with tubulointerstitial damage in patients with lupus nephritis.

Erythrocyte-Bound C4d May Be Useful for SLE Disease Monitoring

Erythrocyte-Bound C4d May Be Useful for SLE Disease Monitoring

Erythrocyte-bound C4d may be useful in monitoring systemic lupus erythematosus.

Poverty, Neighborhood May Affect Outcomes in Systemic Lupus Erythematosus

Poverty, Neighborhood May Affect Outcomes in Systemic Lupus Erythematosus

Outcomes in systemic lupus erythematosus are largely influenced by level of poverty, type of neighborhood of residence, and chronic stress.

Examining Trends of Histologic Presentation, Renal Outcomes in Lupus Nephritis

Examining Trends of Histologic Presentation, Renal Outcomes in Lupus Nephritis

Investigators sought to evaluate changes in demographic, clinical, and histologic presentation in patients with lupus nephritis between 1970 and 2016.

Anti-dsDNA Antibodies Correlated With Clinical, Laboratory Parameters in SLE

Anti-dsDNA Antibodies Correlated With Clinical, Laboratory Parameters in SLE

Female patients with systemic lupus erythematosus who had musculoskeletal symptoms or positive antiphospholipid antibodies demonstrated higher titers of anti-double-stranded DNA antibodies.

Increased Arterial Stiffness Observed in Patients With Systemic Lupus Erythematosus

Increased Arterial Stiffness Observed in Patients With Systemic Lupus Erythematosus

Patients with systemic lupus erythematosus exhibit increased central arterial stiffness compared with a healthy control population.

Pain, Cognitive Dysfunction in SLE Mediated by Sleep Disturbance, Depression

Pain, Cognitive Dysfunction in SLE Mediated by Sleep Disturbance, Depression

The relationship between pain and cognitive dysfunction was explained by sleep disturbance and depressive symptoms.

Bisphosphonate, Vitamin D Combination Therapy May Prevent Atherosclerosis in SLE

Bisphosphonate, Vitamin D Combination Therapy May Prevent Atherosclerosis in SLE

Bisphosphonates and vitamin D may help prevent atherosclerosis in patients with systemic lupus erythematosus.

ACR Provisional Criteria: Global Flares in Childhood-Onset SLE

ACR Provisional Criteria: Global Flares in Childhood-Onset SLE

Provisional criteria for global flares in patients with childhood-onset systemic lupus erythematosus are now available from the ACR.

Effects of SLE Diagnosis Examined in Antiphospholipid Antibody-Positive Patients

Effects of SLE Diagnosis Examined in Antiphospholipid Antibody-Positive Patients

Researchers compared the clinical, laboratory, and treatment characteristics of antiphospholipid antibody-positive patients with or without SLE.

Repeat Antibody Testing May Be Unnecessary for Some Patients With SLE

Repeat Antibody Testing May Be Unnecessary for Some Patients With SLE

Data show that anti-ENA results change infrequently, especially following 1 or more negative tests.

Case Report: Nephrotic Syndrome and Chronic HCV in a 72-Year-Old Woman

Case Report: Nephrotic Syndrome and Chronic HCV in a 72-Year-Old Woman

A 72-year-old Japanese woman with a 40-year history of lupus nephritis presented with leg edema that had lasted for several weeks.

Belimumab Effective for Hypocomplementemic, Anti-dsDNA-Positive SLE

Belimumab Effective for Hypocomplementemic, Anti-dsDNA-Positive SLE

Weekly belimumab treatment was safe and effective and superior to placebo for reducing disease activity over 52 weeks in patients who were hypocomplementemic and anti-dsDNA positive.

Comparing Statin Prescriptions, Lipid Testing in SLE vs Diabetes

Comparing Statin Prescriptions, Lipid Testing in SLE vs Diabetes

Researchers investigated whether patients with SLE receive lipid testing and statin prescriptions comparably with patients with diabetes.

Incident Proteinuria in SLE May Be Predicted by Certain Clinical, Serological Manifestations

Incident Proteinuria in SLE May Be Predicted by Certain Clinical, Serological Manifestations

Certain clinical and serological markers were predictive of future incident proteinuria in patients with systemic lupus erythematosus.

Lupus Is a Leading Cause of Death in Young Women

Lupus Is a Leading Cause of Death in Young Women

Systemic lupus erythematosus is among the top 20 leading causes of death in women between the ages of 5 and 64 years in the United States.

Identifying Social Determinants of Mortality in Systemic Lupus Erythematosus

Identifying Social Determinants of Mortality in Systemic Lupus Erythematosus

Investigators suggest several mechanisms for the contribution of poverty to high mortality rates in patients with systemic lupus erythematosus.

Quality of SLE Care Assessed in Specialized Lupus vs General Rheumatology Clinic

Quality of SLE Care Assessed in Specialized Lupus vs General Rheumatology Clinic

Researchers compared the quality of care received by patients with systemic lupus erythematosus in 2 settings within the same academic institution.

Genetic Risk Loci Found Within Disease Phenotypes Including SLE, JIA

Genetic Risk Loci Found Within Disease Phenotypes Including SLE, JIA

The Epstein-Barr virus EBNA2 protein and many coclustering human transcription factors occupied nearly half of SLE risk loci.

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