Advancing Understanding of Shrinking Lung Syndrome in SLE

The diagnosis and management of shrinking lung syndrome, a rare complication of systemic lupus erythematosus, is discussed in a comprehensive review.

Optimal ANA Cutoff Titer as Entry Criterion for SLE Classification

The new approach in development proposes the use of positive indirect immunofluorescence ANA (IIF-ANA) as an entry criterion for SLE classification.

Lymphoma in Patients With Systemic Lupus Erythematosus: Expert Insights

In this expert interview, Sasha Bernatsky, MD, PhD, and Michelle Petri, MD, MPH, discuss the risk of non-Hodgkin lymphoma in SLE.

Lupus: Using Diet and Nutrition to Improve Symptoms and Outcomes

Consuming adequate amounts of the right nutrients, and limiting others, can help relieve symptoms and improve outcomes in patients with systemic lupus erythematosus.

Applying Precision Medicine to Systemic Lupus Erythematosus

Clinicians and researchers weigh in on the advent of precision medicine for the treatment of SLE.

EULAR Updates Recommendations for Reproductive Planning in SLE

Multidisciplinary experts provide 12 recommendations for the planning and management of pregnancy in systemic lupus erythematosus and/or antiphospholipid syndrome.

Case Study and Clinical Highlight: Respiratory Failure in a Patient With SLE

A female patient with systemic lupus erythematosus presents to the emergency department with an 8 week history of dyspnea, dysphonia, and non-productive cough.

Allograft Survival After Renal Transplantation for Lupus Nephritis

Transplantation is a suitable option for some patients with end-stage renal disease associated with lupus nephritis after careful consideration of several factors.

Revisiting SLE-Related Intestinal Pseudo-Obstruction

Intestinal pseudo-obstruction has been considered a rare complication of SLE, but the condition has not been well defined, with most information coming from case reports.

Can Pharmacogenetics and Precision Medicine Change the Future of SLE Diagnosis and Treatment?

New research may help clinicians better identify individuals with the greatest risk for specific clinical disease features of SLE.

Latest News

Patients with SLE Higher Risk of Developing Metabolic Syndrome

Patients with SLE Higher Risk of Developing Metabolic Syndrome

More than 25% of SLE patients also have metabolic syndrome.

Complement System A Contributer to Lupus Clinical Manifestations

Complement System A Contributer to Lupus Clinical Manifestations

Mannose-binding lectin of the complement system may contribute to the development of clinical manifestations in SLE.

SHARE Launches Childhood-onset Systemic Lupus Erythematosus Initiative

SHARE Launches Childhood-onset Systemic Lupus Erythematosus Initiative

The SHARE initiative established guidelines on cSLE, which is a rare disorder.

Diagnosis and Treatment of Childhood Lupus Nephritis: SHARE Recommendations

Diagnosis and Treatment of Childhood Lupus Nephritis: SHARE Recommendations

The development of lupus nephritis is associated with significant morbidity and mortality.

CVD Prevention Counseling Decreases CVD Risk Factor Prevalence in SLE

CVD Prevention Counseling Decreases CVD Risk Factor Prevalence in SLE

This study finds that a cardiovascular disease prevention counseling program decreases the prevalence of cardiovascular disease risk factors in patients with systemic lupus erythematosus.

B-Cell Depletion Predicts Rituximab Response in Systemic Lupus Erythematosus

B-Cell Depletion Predicts Rituximab Response in Systemic Lupus Erythematosus

Rituximab non-responders may still be amenable to B-cell targeted therapies, such as ofatumumab or obinutuzumab.

No Increased Risk of SLE Found With Current Statin Use

No Increased Risk of SLE Found With Current Statin Use

The risk of developing SLE in current statin users aged ≥40 years was no different than that in nonusers.

Venetoclax Safe, Effective in Women With Systemic Lupus Erythematosus

Venetoclax Safe, Effective in Women With Systemic Lupus Erythematosus

Use of the anti-apoptotic protein B-cell lymphoma 2 inhibitor venetoclax reduced total lymphocyte and disease-relevant B cells in women with SLE.

Systemic Lupus Erythematosus Activity in Pregnant Women Increases After Childbirth

Systemic Lupus Erythematosus Activity in Pregnant Women Increases After Childbirth

SLE was low to absent in pregnant women during conception and pregnancy, but increased after delivery.

SLE: New Candidate Criteria Drafted By Researchers

SLE: New Candidate Criteria Drafted By Researchers

Researchers have created a set of 21 candidate criteria for SLE as part of a multiphase development of a set of criteria for the disease.

Pediatric SLE Pulmonary Function Measures: FENO as Potential Biomarker

Pediatric SLE Pulmonary Function Measures: FENO as Potential Biomarker

FENO monitoring may provide a biomarker of disease activity and signify the emergence of pulmonary involvement in kids with SLE.

Hydroxychloroquine Plus Low-Dose Aspirin Reduces Cardiovascular Events in Systemic Lupus Erythematosus

Hydroxychloroquine Plus Low-Dose Aspirin Reduces Cardiovascular Events in Systemic Lupus Erythematosus

Long-term hydroxychloroquine use, combined with low-dose aspirin, protected against thrombosis in patients with systemic lupus erythematosus.

Diffuse Alveolar Hemorrhage in SLE Associated With Serious Disease Flare

Diffuse Alveolar Hemorrhage in SLE Associated With Serious Disease Flare

This condition is associated with serious disease flare complicated by sepsis and a high mortality rate.

Risk Factors for Depression in Patients With Childhood-Onset Lupus

Risk Factors for Depression in Patients With Childhood-Onset Lupus

Increased disease activity, poorer physical functioning, and lower education attainment were major predictors for depression in adulthood.

Biomarkers of Pulmonary Arterial Hypertension Risk in SLE

Biomarkers of Pulmonary Arterial Hypertension Risk in SLE

Meta-analysis supports anti-RNP and anti-Sm antibodies as serological biomarkers of PAH risk in patients with systemic lupus erythematosus.

Patients With Systemic Lupus Erythematosus and Cognitive Dysfunction Prevalence

Patients With Systemic Lupus Erythematosus and Cognitive Dysfunction Prevalence

MOCA is more effective than the Mini-Mental State Examination at detecting cognitive dysfunction.

Patients With Lupus Have Poor Quality of Sleep, Quality of Life

Patients With Lupus Have Poor Quality of Sleep, Quality of Life

The majority of patients with systemic lupus erythematosus have poor quality of sleep.

Steroid Dosage as Risk Factor for Osteonecrosis in Patients With SLE

Steroid Dosage as Risk Factor for Osteonecrosis in Patients With SLE

Cumulative steroid dosage is a risk factor for the development of osteonecrosis.

SLE in Mothers May Lead to Increased Allergy Risk in Offspring

SLE in Mothers May Lead to Increased Allergy Risk in Offspring

There is an increased risk of allergic conditions in the offspring of mothers with SLE.

Belimumab for SLE: Is Subcutaneous Delivery As Effective as Infusion?

Belimumab for SLE: Is Subcutaneous Delivery As Effective as Infusion?

As intravenous infusion can pose challenges to patients, the current study sought to evaluate the efficacy of subcutaneous belimumab.

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