Systemic Lupus Erythematosus

Improving Rates of Combination Pneumococcal Vaccination in Patients With SLE

Improving Rates of Combination Pneumococcal Vaccination in Patients With SLE

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Vaccination rates in patients with systemic lupus erythematosus improved significantly after the implementation of a multifaceted intervention at a rheumatology practice.

Tacrolimus Possibly Beneficial Long Term in Lupus Nephritis

Tacrolimus Possibly Beneficial Long Term in Lupus Nephritis

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Over a 5-year period, the drug was well tolerated and associated with significant declines in urinary protein-creatinine ratio and mean prednisolone dose.

Childhood-Onset Systemic Lupus Erythematosus Negatively Affects Quality of Life in Adulthood

Childhood-Onset Systemic Lupus Erythematosus Negatively Affects Quality of Life in Adulthood

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Childhood-onset SLE has major effects on quality of life in adulthood.

 Active SLE Disease Activity, Damage Linked to Greater Mortality

Active SLE Disease Activity, Damage Linked to Greater Mortality

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The use of validated disease activity and damage metrics is important in the assessment of SLE.

Effects of Cigarette Smoking, Alcohol Consumption on SLE Risk in Black Women

Effects of Cigarette Smoking, Alcohol Consumption on SLE Risk in Black Women

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Cigarette smoking was associated with an increased SLE risk and alcohol consumption was associated with decreased SLE risk.

Prolonged Antimalarial Exposure Increases Risk for Elevated Cardiac Biomarkers in SLE

Prolonged Antimalarial Exposure Increases Risk for Elevated Cardiac Biomarkers in SLE

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Prolonged antimalarial therapy and persistent creatine phosphokinase elevation resulted in an increased risk for abnormal brain natriuretic peptide and cardiac troponin.

Are Adverse Pregnancy Outcomes Associated With Accelerated Cardiovascular Events in SLE?

Are Adverse Pregnancy Outcomes Associated With Accelerated Cardiovascular Events in SLE?

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The risk factors for accelerated cardiovascular disease among young women with SLE remain unclear, with multiple studies producing conflicting results.

High Rate of Subclinical Myocardial Injury in Systemic Lupus Erythematosus

High Rate of Subclinical Myocardial Injury in Systemic Lupus Erythematosus

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Patients with systemic lupus erythematosus have a high prevalence of subclinical myocardial injury, as evidenced by raised high-sensitive troponin levels.

Characteristics of Early-Onset SLE Distinguished From Mimicking Conditions

Characteristics of Early-Onset SLE Distinguished From Mimicking Conditions

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Patients with early SLE had higher rates of unexplained fever than those with SLE-mimicking conditions.

Lupus Nephritis With Impaired Renal Function Linked to Atherosclerosis in SLE

Lupus Nephritis With Impaired Renal Function Linked to Atherosclerosis in SLE

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Lupus nephritis in combination with impaired renal function is strongly associated with the presence of atherosclerosis in patients with systemic lupus erythematosus.

Outcomes of SLE-Associated Thrombotic Microangiopathy With Acquired ADAMTS13 Deficiency

Outcomes of SLE-Associated Thrombotic Microangiopathy With Acquired ADAMTS13 Deficiency

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Researchers investigated the characteristics and outcomes of patients with systemic lupus erythematosus-associated thrombotic microangiopathy based on their ADAMTS13 inhibitor profiles.

High Risk for Zoster in Cyclophosphamide-Treated SLE, Systemic Vasculitis

High Risk for Zoster in Cyclophosphamide-Treated SLE, Systemic Vasculitis

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The incidence of zoster is high in systemic vasculitis and in patients with SLE exposed to intravenous cyclophosphamide.

Epidemiology, Clinical Characteristics of Systemic Sclerosis vs SSc-SLE Overlap Syndrome

Epidemiology, Clinical Characteristics of Systemic Sclerosis vs SSc-SLE Overlap Syndrome

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Patients with SSc-SLE overlap syndrome were younger at diagnosis, had higher rates of pulmonary arterial hypertension, and less frequently had SSc cutaneous manifestations.

Depression Risk High in Cutaneous, Systemic Lupus Erythematosus

Depression Risk High in Cutaneous, Systemic Lupus Erythematosus

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The risk for depression was increased significantly in patients with systemic lupus erythematosus and cutaneous lupus erythematosus.

Silent Cardiac Impairment May Be Present in New-Onset, Drug-Naive Systemic Lupus Erythematosus

Silent Cardiac Impairment May Be Present in New-Onset, Drug-Naive Systemic Lupus Erythematosus

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Data indicate that drug-naive new onset systemic lupus erythematosus was likely to involve silent cardiac impairment.

Poor Preconceptional Cardiovascular Health Affects Pregnancy Outcomes in SLE

Poor Preconceptional Cardiovascular Health Affects Pregnancy Outcomes in SLE

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Poor preconception cardiovascular health affects pregnancy outcomes in women with SLE.

Burden of Entheseal Sonographic Changes High in Patients With SLE

Burden of Entheseal Sonographic Changes High in Patients With SLE

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The burden of entheseal sonographic changes was significantly higher in patients with SLE vs healthy participants, especially with respect to active inflammation.

Corticosteroid Use Linked to Risk for Osteonecrosis in Systemic Lupus Erythematosus

Corticosteroid Use Linked to Risk for Osteonecrosis in Systemic Lupus Erythematosus

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Investigators sought to identify the risk factors for osteonecrosis and to identify the minimal investigations needed to monitor the risk for osteonecrosis in patients with systemic lupus erythematosus.

Patient-Reported Disease Activity Correlates With Adverse Pregnancy Outcomes in RA

Patient-Reported Disease Activity Correlates With Adverse Pregnancy Outcomes in RA

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A clear difference exists in the utility of patient-reported measures of disease activity in women with SLE and those with RA.

Examining the Prevalence, Characteristics of Monophasic Disease Course in SLE

Examining the Prevalence, Characteristics of Monophasic Disease Course in SLE

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Researchers sought to assess the prevalence and characteristics of monophasic disease course in a defined cohort of patients with SLE.

Comparing Factors Associated With Tubulointerstitial Inflammation in Lupus Nephritis

Comparing Factors Associated With Tubulointerstitial Inflammation in Lupus Nephritis

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Routinely available serologic markers have no correlation with tubulointerstitial damage in patients with lupus nephritis.

Poverty, Neighborhood May Affect Outcomes in Systemic Lupus Erythematosus

Poverty, Neighborhood May Affect Outcomes in Systemic Lupus Erythematosus

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Outcomes in systemic lupus erythematosus are largely influenced by level of poverty, type of neighborhood of residence, and chronic stress.

SLE-DAS Superior to SLEDAI-2K in Detecting Changes in SLE Disease Activity

SLE-DAS Superior to SLEDAI-2K in Detecting Changes in SLE Disease Activity

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To assess validity of SLE-DAS, investigators performed a Spearman's correlation between SLE-DAS, PGA, and SLEDAI-2K at the last follow-up visit.

Cardiac Screening May Not Be Beneficial in SLE With Anti-Ro Antibodies

Cardiac Screening May Not Be Beneficial in SLE With Anti-Ro Antibodies

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Cardiac screening in patients with systemic lupus erythematosus and anti-Ro-positive antibodies does not appear to be beneficial in clinical practice.

Baricitinib Shows Positive Results for Systemic Lupus Erythematosus in Phase 2 Study

Baricitinib Shows Positive Results for Systemic Lupus Erythematosus in Phase 2 Study

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Baricitinib 4 mg was safe and effective in patients with systemic lupus erythematosus.

Determining Elevated Thrombotic Risk in Systemic Lupus Erythematosus

Determining Elevated Thrombotic Risk in Systemic Lupus Erythematosus

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Recent data from EULAR 2018 highlight the existence of thrombotic factors in systemic lupus erythematosus.

Obesity May Not Be Associated With Development of Lupus Nephritis

Obesity May Not Be Associated With Development of Lupus Nephritis

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Obesity is not associated with the development of lupus nephritis among patients with systemic lupus erythematosus.

Examining Trends of Histologic Presentation, Renal Outcomes in Lupus Nephritis

Examining Trends of Histologic Presentation, Renal Outcomes in Lupus Nephritis

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Investigators sought to evaluate changes in demographic, clinical, and histologic presentation in patients with lupus nephritis between 1970 and 2016.

Anti-dsDNA Antibodies Correlated With Clinical, Laboratory Parameters in SLE

Anti-dsDNA Antibodies Correlated With Clinical, Laboratory Parameters in SLE

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Female patients with systemic lupus erythematosus who had musculoskeletal symptoms or positive antiphospholipid antibodies demonstrated higher titers of anti-double-stranded DNA antibodies.

Managing Cognitive Dysfunction in Systemic Lupus Erythematosus

Managing Cognitive Dysfunction in Systemic Lupus Erythematosus

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The pathogenic pathways of SLE-related cognitive dysfunction are yet to be fully elucidated, but vasculopathy, antibody-mediated neurotoxicity, impairments in cytokine signaling, and complement abnormalities have been proposed as contributing factors.

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