Systemic Lupus Erythematosus

The Handoff: Your Week in Rheumatology News - 3/24/17

The Handoff: Your Week in Rheumatology News - 3/24/17

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New guidelines for rheumatoid arthritis treatment with DMARDs and money being steered into lupus research highlight this week's The Handoff.

Reduced Psychosocial Reserve Linked to Increased SLE Disease Burden

Reduced Psychosocial Reserve Linked to Increased SLE Disease Burden

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Patients with systemic lupus erythematosus and low self-esteem reported higher levels of anxiety and depression.

High-dose Steroids Increase Serious Infection Risk in Pregnant Women With Inflammatory Conditions

High-dose Steroids Increase Serious Infection Risk in Pregnant Women With Inflammatory Conditions

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An observational cohort study of 4961 women with completed pregnancies and a recorded diagnosis of systemic inflammatory conditions.

Elevated Disease Markers Identified in Relatives of Patients With Lupus

Elevated Disease Markers Identified in Relatives of Patients With Lupus

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Changes in levels of soluble mediators may predict SLE transition in unaffected relatives of patients.

Lupus Family Planning Recommendations Issued by EULAR

Lupus Family Planning Recommendations Issued by EULAR

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A European League Against Rheumatism writing committee has issued recommendations for family planning for women with systemic lupus erythematosus and antiphospholipid syndrome based on a systemic review.

Lupus: Using Diet and Nutrition to Improve Symptoms and Outcomes

Lupus: Using Diet and Nutrition to Improve Symptoms and Outcomes

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Consuming adequate amounts of the right nutrients, and limiting others, can help relieve symptoms and improve outcomes in patients with systemic lupus erythematosus.

Lupus Among Autoimmune Diseases Tied to Subsequent Dementia Risk

Lupus Among Autoimmune Diseases Tied to Subsequent Dementia Risk

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Study reviewed information from 1.8 million individuals in England admitted to a hospital with an autoimmune disease.

The Handoff: Your Week in Rheumatology News - 3/3/17

The Handoff: Your Week in Rheumatology News - 3/3/17

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Connecticut considers rheumatoid arthritis and fibromyalgia for medical marijuana treatment, while Lyme disease-carrying deer ticks continue to invade Michigan. All this and more in this week's edition.

Adults With Lupus More Likely to Have Depression and Anxiety

Adults With Lupus More Likely to Have Depression and Anxiety

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The researchers conducted a systematic review of data from 59 studies.

Researchers Examine Potential Key to Future Lupus Treatments

Researchers Examine Potential Key to Future Lupus Treatments

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Research examined virus-independent activation of MAVS protein in patients with systemic lupus erythematosus.

Drug-Induced Lupus Observed With Adalimumab Treatment For Psoriasis

Drug-Induced Lupus Observed With Adalimumab Treatment For Psoriasis

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Investigators observe patient develop drug-induced lupus while taking biologic treatment for psoriasis.

Lupus Research Grants Available for Post-Graduate Study

Lupus Research Grants Available for Post-Graduate Study

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The Lupus Foundation of America is now accepting applications for 8 grants, with dedicated awards to minority applicants, pediatric research, and research that has an impact on rural areas.

<i>In Vitro</i> Fertilization is Safe and Effective in SLE and APS

In Vitro Fertilization is Safe and Effective in SLE and APS

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Study evaluated the complications and success rates for IVF in women with systemic lupus erythematosus or antiphospholipid syndrome.

Systemic Lupus Erythematosus Increases Incidence of High-Risk HPV

Systemic Lupus Erythematosus Increases Incidence of High-Risk HPV

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Three-year follow-up shows statistically significant increase in cumulative presence of HPV infection.

End-Stage Renal Disease Risk Higher in SLE Patients Hospitalized for Infections

End-Stage Renal Disease Risk Higher in SLE Patients Hospitalized for Infections

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End-stage renal disease is 5-fold more likely to develop in patients with 3 or more infection-related hospitalizations versus none.

Cognitive Dysfunction, Memory Impairment Evaluated by fMRI in Non-Neuropsychiatric SLE

Cognitive Dysfunction, Memory Impairment Evaluated by fMRI in Non-Neuropsychiatric SLE

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Functional MRI imaging in patients with non-neuropsychiatric systemic lupus erythematosus found that defects in spatial working memory and cognitive dysfunction were related to damage in specific neural networks.

Depression in Systemic Lupus Erythematosus Linked to Cardiovascular Disease

Depression in Systemic Lupus Erythematosus Linked to Cardiovascular Disease

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Women with systemic lupus erythematosus and depression were more likely to have increased carotid intima-media thickness compared with those with SLE without depression.

No Increased Risk of CV Death in Cutaneous Lupus Erythematosus

No Increased Risk of CV Death in Cutaneous Lupus Erythematosus

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Patients with cutaneous lupus erythematosus (CLE) were assessed for their risk of cerebrovascular accidents, ischemic heart disease, and peripheral arterial disease.

Efficacy of Targeted Interferon-α Inhibition in SLE

Efficacy of Targeted Interferon-α Inhibition in SLE

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Eligible participants participated in a phase IIb trial of sifalimumab to determine the drug's effect on moderate-to-severe active SLE.

RCT: Mind-Body Training Improves Depressive Symptoms in SLE

RCT: Mind-Body Training Improves Depressive Symptoms in SLE

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A randomized-control trial found that mind-body skills training improved depressive symptoms in patients with SLE.

CVD Risks in SLE Mitigated With Counseling Program

CVD Risks in SLE Mitigated With Counseling Program

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Although many patients do not typically consider SLE to be a risk factor for CVD, research indicates that these patients are at a higher risk for CVD and related diseases.

EULAR Updates Recommendations for Reproductive Planning in SLE

EULAR Updates Recommendations for Reproductive Planning in SLE

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Multidisciplinary experts provide 12 recommendations for the planning and management of pregnancy in systemic lupus erythematosus and/or antiphospholipid syndrome.

Novel Urinary Biomarker Index to Noninvasively Assess LN

Novel Urinary Biomarker Index to Noninvasively Assess LN

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The Renal Activity Index for Lupus (RAIL) was developed by researchers utilizing urinary biomarkers of LN as a way non-invasively assess degrees of LN inflammation.

Novel Shared Genetic Risk Locus Identified for RA and SLE

Novel Shared Genetic Risk Locus Identified for RA and SLE

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A shared genetic locus (COG6) increased the risk for both systemic lupus erythematosus and rheumatoid arthritis.

Should Asymptomatic Pediatric Patients With Prolonged PTT Be Screened for LAC?

Should Asymptomatic Pediatric Patients With Prolonged PTT Be Screened for LAC?

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Children with prolonged partial thromboplastin time (PTT) should be screened for lupus anticoagulant (LAC), regardless of their history of bleeding problem

Long-Term Rates of SLE Flares After Clinical Remission

Long-Term Rates of SLE Flares After Clinical Remission

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Retrospective data from a single center showed that 22.4% of patients with SLE will have a disease flare even after 3 years of remission. What are the implications for clinical follow-up?

Addressing Altered Vaccine Immunogenicity and Low Vaccination Rates in Rheumatic Disease

Addressing Altered Vaccine Immunogenicity and Low Vaccination Rates in Rheumatic Disease

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Despite decades of research on the disproportionate impact of infection on those with rheumatic disease, patients in this population are less likely than those without rheumatic disease to undergo routine vaccination against preventable diseases.

Web-Based Tool Assists SLE Patients in Disease Self-Management

Web-Based Tool Assists SLE Patients in Disease Self-Management

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The Lupus Interactive Navigator tool examined in this study offers a unique way to help patients self-manage SLE.

Hyponatremia in SLE Associated With Markers of Inflammation

Hyponatremia in SLE Associated With Markers of Inflammation

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In this cohort of patients, hyponatremia was associated with increased ESR, CRP, and SLEDAI scores, which could be suggestive of the relationship between hyponatremia and degree of inflammation un SLE.

VIDEO: SLE Case Study Overview

Case Study Involving a Patient With Systemic Lupus Erythematosus

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