Systemic Lupus Erythematosus

Active Nephritis in Active SLE: Identification of a New Biomarker

Active Nephritis in Active SLE: Identification of a New Biomarker

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Anti-ficolin-2 autoantibodies may represent a biomarker for renal manifestations in patients with active systemic lupus erythematosus.

Association Between SLE Disease Activity and Omega Fatty Acids, Vitamin D

Association Between SLE Disease Activity and Omega Fatty Acids, Vitamin D

Low vitamin D is linked with later total organ and renal damage in patients with SLE.

EULAR/ACR Systemic Lupus Erythematosus Classification Criteria Update

EULAR/ACR Systemic Lupus Erythematosus Classification Criteria Update

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EULAR and ACR jointly funded and collaborated on creating a set of criteria that can be used to more accurately identify patients with SLE for inclusion in clinical trials.

Obesity, Disease Activity Paradox Found in Systemic Lupus Erythematosus

Obesity, Disease Activity Paradox Found in Systemic Lupus Erythematosus

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Researchers studied how BMI changes would affect disease activity in systemic lupus erythematosus

Pregnancy Outcomes in SLE vs Other Connective Tissue, Inflammatory Rheumatic Conditions

Pregnancy Outcomes in SLE vs Other Connective Tissue, Inflammatory Rheumatic Conditions

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Real-world data indicate that although most patients with systemic lupus erythematosus or connective tissue diseases have successful pregnancies, more adverse pregnancy outcomes occur.

Obesity Leads to Poor Outcomes for Patients with Systemic Lupus Erythematosus

Obesity Leads to Poor Outcomes for Patients with Systemic Lupus Erythematosus

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The impact of excess adiposity in SLE has not been established, despite obesity being a common comorbidity in SLE.

Childhood-Onset SLE Predicts Steroid Damage Over Time

Childhood-Onset SLE Predicts Steroid Damage Over Time

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Little is known about differences in long-term steroid toxicity between adults with cSLE and aSLE.

Systemic Lupus Erythematous Responder Index: Primary Drivers

Systemic Lupus Erythematous Responder Index: Primary Drivers

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The efficacy variables with the greatest effect on systemic lupus erythematous (SLE) Responder Index responder status in clinical trials include SLE Disease Activity Index improvement, concomitant medication adherence, and trial completion.

Unmet Needs in the Pathogenesis, Treatment of Systemic Lupus Erythematosus

Unmet Needs in the Pathogenesis, Treatment of Systemic Lupus Erythematosus

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Improved survival has ushered in new challenges that inadvertently increase the risk for death in patients with SLE.

Despite Decline, SLE Mortality Rates Remain Higher Than Non-SLE Mortality Rates

Despite Decline, SLE Mortality Rates Remain Higher Than Non-SLE Mortality Rates

Even though SLE mortality rates are down, they're still higher than non-SLE mortality.

Anti-Ro/SSA-Positive Pregnancies and Fetal Cardiac Conduction Disturbances

Anti-Ro/SSA-Positive Pregnancies and Fetal Cardiac Conduction Disturbances

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The recurrence of fetal cardiac conduction disturbances in the fetuses of women expressing anti-Ro/SSA antibodies may be influenced by the season of the year and maternal age.

Cardiovascular Disease Risk in Patients With Systemic Lupus Erythematosus

Cardiovascular Disease Risk in Patients With Systemic Lupus Erythematosus

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Improved treatment in SLE with increased life expectancy has been accompanied by an elevated risk for developing cardiovascular diseases.

Impact of Remission, Low Disease Activity on Outcomes in Lupus

Impact of Remission, Low Disease Activity on Outcomes in Lupus

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While a treat to target strategy has been proposed for managing SLE, the impact of possible disease outcomes has not been fully evaluated.

Systemic Lupus Erythematosus-Associated Cognitive Impairment May Be Identified With New Screening Tool

Systemic Lupus Erythematosus-Associated Cognitive Impairment May Be Identified With New Screening Tool

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The high prevalence of cognitive impairment in patients with SLE creates a need for a reliable and cost-effective screening tool.

Hydroxychloroquine Effects on Cholesterol Levels in Systemic Lupus Erythematosus

Hydroxychloroquine Effects on Cholesterol Levels in Systemic Lupus Erythematosus

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Research revealed that hydroxychloroquine is associated with reduced LDL-C and total cholesterol levels in patients with lupus.

Advancing Understanding of Shrinking Lung Syndrome in SLE

Advancing Understanding of Shrinking Lung Syndrome in SLE

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The diagnosis and management of shrinking lung syndrome, a rare complication of systemic lupus erythematosus, is discussed in a comprehensive review.

No Increased Risk of SLE Found With Current Statin Use

No Increased Risk of SLE Found With Current Statin Use

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The risk of developing SLE in current statin users aged ≥40 years was no different than that in nonusers.

Venetoclax Safe, Effective in Women With Systemic Lupus Erythematosus

Venetoclax Safe, Effective in Women With Systemic Lupus Erythematosus

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Use of the anti-apoptotic protein B-cell lymphoma 2 inhibitor venetoclax reduced total lymphocyte and disease-relevant B cells in women with SLE.

Chronic Inflammatory Disorders May Increase Cardiometabolic, Mortality Risks

Chronic Inflammatory Disorders May Increase Cardiometabolic, Mortality Risks

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The degree of risk for cardiometabolic events and all-cause mortality appeared to increase in participants who took nonsteroidal anti-inflammatory drugs or corticosteroid drugs.

Guidelines for Peri-Op Care in Rheumatic Disease

Guidelines for Peri-Op Care in Rheumatic Disease

These guidelines address the use of antirheumatic drugs for adults with RA, SpA, JIA, and SLE undergoing THA or TKA.

Optimal ANA Cutoff Titer as Entry Criterion for SLE Classification

Optimal ANA Cutoff Titer as Entry Criterion for SLE Classification

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The new approach in development proposes the use of positive indirect immunofluorescence ANA (IIF-ANA) as an entry criterion for SLE classification.

Risk Factors for Depression in Patients With Childhood-Onset Lupus

Risk Factors for Depression in Patients With Childhood-Onset Lupus

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Increased disease activity, poorer physical functioning, and lower education attainment were major predictors for depression in adulthood.

Biomarkers of Pulmonary Arterial Hypertension Risk in SLE

Biomarkers of Pulmonary Arterial Hypertension Risk in SLE

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Meta-analysis supports anti-RNP and anti-Sm antibodies as serological biomarkers of PAH risk in patients with systemic lupus erythematosus.

Patients With Systemic Lupus Erythematosus and Cognitive Dysfunction Prevalence

Patients With Systemic Lupus Erythematosus and Cognitive Dysfunction Prevalence

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MOCA is more effective than the Mini-Mental State Examination at detecting cognitive dysfunction.

Patients With Lupus Have Poor Quality of Sleep, Quality of Life

Patients With Lupus Have Poor Quality of Sleep, Quality of Life

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The majority of patients with systemic lupus erythematosus have poor quality of sleep.

Steroid Dosage as Risk Factor for Osteonecrosis in Patients With SLE

Steroid Dosage as Risk Factor for Osteonecrosis in Patients With SLE

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Cumulative steroid dosage is a risk factor for the development of osteonecrosis.

Lymphoma in Patients With Systemic Lupus Erythematosus: Expert Insights

Lymphoma in Patients With Systemic Lupus Erythematosus: Expert Insights

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In this expert interview, Sasha Bernatsky, MD, PhD, and Michelle Petri, MD, MPH, discuss the risk of non-Hodgkin lymphoma in SLE.

SLE in Mothers May Lead to Increased Allergy Risk in Offspring

SLE in Mothers May Lead to Increased Allergy Risk in Offspring

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There is an increased risk of allergic conditions in the offspring of mothers with SLE.

Belimumab for SLE: Is Subcutaneous Delivery As Effective as Infusion?

Belimumab for SLE: Is Subcutaneous Delivery As Effective as Infusion?

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As intravenous infusion can pose challenges to patients, the current study sought to evaluate the efficacy of subcutaneous belimumab.

Genetic Variant Tied to SLE and MS Identified

Genetic Variant Tied to SLE and MS Identified

BAFF variant was likely selected over time as an adaptive response to malaria.

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