Systemic Lupus Erythematosus

Chronic Inflammatory Disorders May Increase Cardiometabolic, Mortality Risks

Chronic Inflammatory Disorders May Increase Cardiometabolic, Mortality Risks

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The degree of risk for cardiometabolic events and all-cause mortality appeared to increase in participants who took nonsteroidal anti-inflammatory drugs or corticosteroid drugs.

Guidelines for Peri-Op Care in Rheumatic Disease

Guidelines for Peri-Op Care in Rheumatic Disease

These guidelines address the use of antirheumatic drugs for adults with RA, SpA, JIA, and SLE undergoing THA or TKA.

Optimal ANA Cutoff Titer as Entry Criterion for SLE Classification

Optimal ANA Cutoff Titer as Entry Criterion for SLE Classification

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The new approach in development proposes the use of positive indirect immunofluorescence ANA (IIF-ANA) as an entry criterion for SLE classification.

Risk Factors for Depression in Patients With Childhood-Onset Lupus

Risk Factors for Depression in Patients With Childhood-Onset Lupus

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Increased disease activity, poorer physical functioning, and lower education attainment were major predictors for depression in adulthood.

Biomarkers of Pulmonary Arterial Hypertension Risk in SLE

Biomarkers of Pulmonary Arterial Hypertension Risk in SLE

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Meta-analysis supports anti-RNP and anti-Sm antibodies as serological biomarkers of PAH risk in patients with systemic lupus erythematosus.

Patients With Systemic Lupus Erythematosus and Cognitive Dysfunction Prevalence

Patients With Systemic Lupus Erythematosus and Cognitive Dysfunction Prevalence

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MOCA is more effective than the Mini-Mental State Examination at detecting cognitive dysfunction.

Patients With Lupus Have Poor Quality of Sleep, Quality of Life

Patients With Lupus Have Poor Quality of Sleep, Quality of Life

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The majority of patients with systemic lupus erythematosus have poor quality of sleep.

Steroid Dosage as Risk Factor for Osteonecrosis in Patients With SLE

Steroid Dosage as Risk Factor for Osteonecrosis in Patients With SLE

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Cumulative steroid dosage is a risk factor for the development of osteonecrosis.

Lymphoma in Patients With Systemic Lupus Erythematosus: Expert Insights

Lymphoma in Patients With Systemic Lupus Erythematosus: Expert Insights

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In this expert interview, Sasha Bernatsky, MD, PhD, and Michelle Petri, MD, MPH, discuss the risk of non-Hodgkin lymphoma in SLE.

SLE in Mothers May Lead to Increased Allergy Risk in Offspring

SLE in Mothers May Lead to Increased Allergy Risk in Offspring

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There is an increased risk of allergic conditions in the offspring of mothers with SLE.

Belimumab for SLE: Is Subcutaneous Delivery As Effective as Infusion?

Belimumab for SLE: Is Subcutaneous Delivery As Effective as Infusion?

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As intravenous infusion can pose challenges to patients, the current study sought to evaluate the efficacy of subcutaneous belimumab.

Genetic Variant Tied to SLE and MS Identified

Genetic Variant Tied to SLE and MS Identified

BAFF variant was likely selected over time as an adaptive response to malaria.

International Panel Releases Guidelines for Biologics Use in Lupus

International Panel Releases Guidelines for Biologics Use in Lupus

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The guidelines were established by a mutidisciplinary group of experts with a goal of optimizing lupus outcomes for all patients.

Relative Risk of Ischemic Stroke Doubled in Systemic Lupus Erythematosus

Relative Risk of Ischemic Stroke Doubled in Systemic Lupus Erythematosus

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A matched cohort study compared the risk of incident stroke in individuals with SLE with individuals without SLE in the general population.

The Handoff: Your Week in Rheumatology News - 4/14/17

The Handoff: Your Week in Rheumatology News - 4/14/17

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This week, a phase III trial for investigational drug voclosporin for lupus nephritis treatment was approved, prolonged insomnia may lead to less robust bone formation — causing osteoporosis and bone fractures — and researchers found that women who drink a moderate amount of alcohol daily have a reduced risk of developing systemic lupus erythmatosus.

Lupus Low-disease Activity State Can Predict Flare-up Risk

Lupus Low-disease Activity State Can Predict Flare-up Risk

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Asia-Pacific Lupus Collaborative's low-disease activity score can predict risk of flare-ups, according to research from a group at Hong Kong University.

Reduced Lupus Risk Linked to Moderate Alcohol Consumption in Women

Reduced Lupus Risk Linked to Moderate Alcohol Consumption in Women

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The study evaluated 2 groups of women from the Nurses' Health Study (NHS) and NHSII cohorts, examining alcohol consumption and the onset of systemic lupus erythematosus.

Systemic Lupus Erythematosus Leads to Lower Quality-of-Life Measures

Systemic Lupus Erythematosus Leads to Lower Quality-of-Life Measures

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Study of patients with systemic lupus erythematosus in China evaluates quality of life measures in several areas.

The Handoff: Your Week in Rheumatology News - 3/24/17

The Handoff: Your Week in Rheumatology News - 3/24/17

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New guidelines for rheumatoid arthritis treatment with DMARDs and money being steered into lupus research highlight this week's The Handoff.

Reduced Psychosocial Reserve Linked to Increased SLE Disease Burden

Reduced Psychosocial Reserve Linked to Increased SLE Disease Burden

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Patients with systemic lupus erythematosus and low self-esteem reported higher levels of anxiety and depression.

High-dose Steroids Increase Serious Infection Risk in Pregnant Women With Inflammatory Conditions

High-dose Steroids Increase Serious Infection Risk in Pregnant Women With Inflammatory Conditions

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An observational cohort study of 4961 women with completed pregnancies and a recorded diagnosis of systemic inflammatory conditions.

Elevated Disease Markers Identified in Relatives of Patients With Lupus

Elevated Disease Markers Identified in Relatives of Patients With Lupus

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Changes in levels of soluble mediators may predict SLE transition in unaffected relatives of patients.

Lupus Family Planning Recommendations Issued by EULAR

Lupus Family Planning Recommendations Issued by EULAR

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A European League Against Rheumatism writing committee has issued recommendations for family planning for women with systemic lupus erythematosus and antiphospholipid syndrome based on a systemic review.

Lupus: Using Diet and Nutrition to Improve Symptoms and Outcomes

Lupus: Using Diet and Nutrition to Improve Symptoms and Outcomes

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Consuming adequate amounts of the right nutrients, and limiting others, can help relieve symptoms and improve outcomes in patients with systemic lupus erythematosus.

Lupus Among Autoimmune Diseases Tied to Subsequent Dementia Risk

Lupus Among Autoimmune Diseases Tied to Subsequent Dementia Risk

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Study reviewed information from 1.8 million individuals in England admitted to a hospital with an autoimmune disease.

The Handoff: Your Week in Rheumatology News - 3/3/17

The Handoff: Your Week in Rheumatology News - 3/3/17

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Connecticut considers rheumatoid arthritis and fibromyalgia for medical marijuana treatment, while Lyme disease-carrying deer ticks continue to invade Michigan. All this and more in this week's edition.

Adults With Lupus More Likely to Have Depression and Anxiety

Adults With Lupus More Likely to Have Depression and Anxiety

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The researchers conducted a systematic review of data from 59 studies.

Researchers Examine Potential Key to Future Lupus Treatments

Researchers Examine Potential Key to Future Lupus Treatments

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Research examined virus-independent activation of MAVS protein in patients with systemic lupus erythematosus.

Drug-Induced Lupus Observed With Adalimumab Treatment For Psoriasis

Drug-Induced Lupus Observed With Adalimumab Treatment For Psoriasis

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Investigators observe patient develop drug-induced lupus while taking biologic treatment for psoriasis.

Lupus Research Grants Available for Post-Graduate Study

Lupus Research Grants Available for Post-Graduate Study

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The Lupus Foundation of America is now accepting applications for 8 grants, with dedicated awards to minority applicants, pediatric research, and research that has an impact on rural areas.

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