Carlene Majorino

All articles by Carlene Majorino

Evidence suggests 19% to 40% of those who are aPL-positive and 42% to 80% of those with primary APS have CD.3 In addition, 2.5% of patients with APS have multi-infarct dementia resulting from recurrent ischemic events.6 Because cognitive deficits are also observed in patients with APS who have no evidence of neurologic involvement, the mechanism of CD in APS is likely multifactorial.3,7 Animal studies have also observed CD in APS models with no evidence of ischemic lesions, and findings suggest that aPL antibodies may affect brain tissue directly.3,7 The spectrum of CD varies from mild to severe, but deficits in attention, concentration, processing speed, executive function, and memory loss are common.3 Patients with APS-related dementia may have impaired judgment, language impairment, and memory loss that can be severe enough to arouse suspicion of Alzheimer disease.6,8 Empirical observation has shown that anticoagulation therapy improves memory loss in some patients.8 Image Credit: ISM/SOVEREIGN

Dementia Associated With RA, But Mitigation Depends on Lifestyle

Carlene Majorino

August 3, 2021

We spoke with 2 rheumatologists with recent research on dementia and RA who believe that exercise, well-being, and antiinflammatory drugs are crucial to treatment and prevention.

Rheumatoid Arthritis Advisor

Q&A: Reactive Oxygen Species and Muscle Dysfunction in Rheumatoid Arthritis

Carlene Majorino

July 7, 2021

Dr Johanna Lanner discusses her research team’s publication about oxygenic free radicals and their association with muscle weakness in rheumatoid arthritis (RA).

Rheumatoid Arthritis Advisor

Q&A: Inhalants Other Than Personal Smoking and Rheumatoid Arthritis

Carlene Majorino

June 18, 2021

Jeffrey Sparks, MD, MMSc, says it’s difficult to single out environmental risk factors for RA because of the intersectional nature of patients’ conditions and exposures.

Next post in Rheumatoid Arthritis Advisor

Carlene Majorino

All articles by Carlene Majorino

Dementia Associated With RA, But Mitigation Depends on Lifestyle

Q&A: Reactive Oxygen Species and Muscle Dysfunction in Rheumatoid Arthritis

Q&A: Inhalants Other Than Personal Smoking and Rheumatoid Arthritis

Risk for Interstitial Lung Disease in RA Linked to Age at Diagnosis and Duration of RA