CJ Arlotta

A populated-based study was conducted to assess if peripheral nerve blocks would improve perioperative outcomes and resource utilization in patients undergoing primary total hip and knee arthroplasty.

This study suggests that patients with fibromyalgia (FM) have intact homeostatic sleep drives when compared to patients with primary insomnia. So, despite shorter total mean duration of sleep bouts in both FM and primary insomnia patients, patients with FM had shorter wake bouts.

An increase in transthyretin (TTR) autoantibodies was found in the JIA population as compared with controls.

Treatment with low dose naltrexone may be an effective, highly tolerable and inexpensive treatment for fibromyalgia.

In an experimental murine model, FK506 binding protein 51 (FKBP 51) is crucial for the full development and maintenance of long-term pain states. This suggests that FKBP51 is involved in chronic pain regulation, and if further validated in human studies, can potentially be a new pharmacologic target for the treatment of chronic pain.