The discontinuation of denosumab is associated with increased bone turnover markers and bone loss, but prior treatment with bisphosphonates did not seem to prevent the development of these complications.
All articles by Roxanne Nelson
Lateral areal bone mineral density can identify microstructural heterogeneities that are independent of age and has advantages over anterior-posterior DXA scanning for fracture risk assessment.
Both high and low niacin intake was associated with a risk for incident hip fractures in older adults.
Total use of medications for treating osteoporosis in Denmark reached a plateau in 2014, and hip fracture rates declined by 30% from 2005 to 2015.
Denosumab inhibits osteoclast formation and activity in cortical bone, and this mechanism of action may be reﬂected by the reduction of erosion in both depth and surface.
The use of gentamicin-impregnated beads and/or sponges should be discouraged in early acute periprosthetic joint infection as their use is associated with high failure rates.
There is little justification for the use of vitamin D supplements to maintain or improve musculoskeletal health.
A corrected HbA1c factor may improve the ability to predict the risk for fracture by the FRAX algorithm in T2D.
Investigators examined the effect of consuming a Mediterranean-style diet for 1 year on inflammatory response and bone health in the elderly.
Romosozumab increased spine and hip bone mineral density after 12 months of treatment.
Accurate and rapid diagnostics methods are needed to inform initial clinical decision making for patients with hip monoarthritis.
Findings do not support a role for subclinical thyroid dysfunction as a biomarker for bone-related outcomes in older men.
Researchers showed that improved glycemic control is associated with higher bone resorption, possibly reflecting normalization rather than an abnormal increase in bone resorption.
A high stress fracture rate in oligo-amenorrheic athletes, who have whole body, less head and hip, areal bone mineral density (BMD) measures comparable to those of control patients, indicates that BMD in these women may need to be even higher to avoid fractures.
Researchers found that estimation of hip fracture risk without accounting for death as a competing event results in an overestimation of fracture risk.
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