Cryoglobulinemia (Cold-related gelling, Cold- related agglutination, Cutaneous manifestations of microvascular occlusion syndromes, Cryoglobulinemic syndrome [clinically asymptomatic]), Cryoglobulinemic vasculitis (clinically apparent disease process)
Are You Confident of the Diagnosis? What you should be alert for in the history Patients may give a history of Raynaud’s phenomenon, arthralgia, myalgia, or signs of palpable purpura in the context of a connective tissue disease, lymphoproliferative disorders or infectious diseases. Thirty to fifty percent of cases occur without any systemic underlying condition…