Axial Spondyloarthritis

Inflammatory Back Pain and Neuropathic Pain May Affect Axial Spondyloarthritis Outcomes

Inflammatory Back Pain and Neuropathic Pain May Affect Axial Spondyloarthritis Outcomes

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Patients with axial spondyloarthritis who have inflammatory back pain or neuropathic pain may have higher pain intensity, pain interference, disease activity, and greater functional limitation compared with individuals with axial spondyloarthritis but without either comorbidity.

Greater Baseline Symptom Burden Linked to Poorer TNFi Response Rates in axSpA

Greater Baseline Symptom Burden Linked to Poorer TNFi Response Rates in axSpA

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Patients who reported a greater symptom burden at the start of TNFi treatment had poor response rates and low retention rates.

MR-VIBE More Sensitive for Detecting Erosions in Sacroiliac Joints

MR-VIBE More Sensitive for Detecting Erosions in Sacroiliac Joints

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VIBE detected erosions in the sacroiliac joints with higher sensitivity without a loss of specificity and superior reliability compared with a standard T1-weighted sequence.

Gender Differences, Clinical Outcomes of Pain in Axial Spondyloarthritis

Gender Differences, Clinical Outcomes of Pain in Axial Spondyloarthritis

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The location and spread of pain in patients with axial spondyloarthritis was different between genders and was related to worse clinical status.

Biologic Therapy Improves Work Productivity in Axial Spondyloarthritis

Biologic Therapy Improves Work Productivity in Axial Spondyloarthritis

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Consistent data show that treatment with biologic therapy significantly improves work productivity and activity impairment among patients with axial spondyloarthritis.

Identifying Early Structural Changes in Axial Spondyloarthritis: A Comparison of Scoring Methods

Identifying Early Structural Changes in Axial Spondyloarthritis: A Comparison of Scoring Methods

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Investigators compared the performance of different spinal radiographic damage scoring methods in patients with early axial spondyloarthritis.

Comorbid Fibromyalgia Influences Disease Activity, Quality of Life in Axial Spondyloarthritis

Comorbid Fibromyalgia Influences Disease Activity, Quality of Life in Axial Spondyloarthritis

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Meeting the criteria for fibromyalgia had a modest effect on disease activity and did not influence the response to TNFi therapy.

Depression Associated With More Severe Disease Activity, Functional Impairment in axSpA

Depression Associated With More Severe Disease Activity, Functional Impairment in axSpA

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Depression is common in patients with axSpA and is associated with more severe disease activity and functional impairment.

Differentiating Between axSpA, Degenerative Disease Abnormalities on MRI, Radiographs

Differentiating Between axSpA, Degenerative Disease Abnormalities on MRI, Radiographs

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Researchers sought to assess whether it is possible to discriminate between degenerative changes and lesions associated with axSpA.

Adalimumab Continuation Linked to Fewer Flares After Remission in Nonradiographic axSpA

Adalimumab Continuation Linked to Fewer Flares After Remission in Nonradiographic axSpA

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In patients with nonradiographic axial spondyloarthritis who achieve remission with adalimumab, continued therapy was linked to fewer flares vs treatment withdrawal.

Novel Automated Mobility Measure Yields High Reproducibility in Axial Spondyloarthritis

Novel Automated Mobility Measure Yields High Reproducibility in Axial Spondyloarthritis

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Researchers assessed the reproducibility of UCOASMI in clinical practice settings.

Gender Differences in Axial Spondyloarthritis: Comparing Disease Burden and Treatment

Gender Differences in Axial Spondyloarthritis: Comparing Disease Burden and Treatment

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An improved understanding of the gender differences in axial spondyloarthritis can improve disease treatment and reduce disease burden.

ASAS Health Index Valid, Reliable in Axial and Peripheral Spondyloarthritis

ASAS Health Index Valid, Reliable in Axial and Peripheral Spondyloarthritis

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The Assessment of Spondyloarthritis International Society Health Index proved to be valid, reliable, and responsive.

Effects of Maternal axSpA Disease Activity on Pregnancy Outcomes Examined

Effects of Maternal axSpA Disease Activity on Pregnancy Outcomes Examined

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A systematic review revealed no signal for increased pregnancy loss in patients with axial spondyloarthritis.

Ustekinumab, TNF Inhibitors Improve 6-Month Outcomes in Psoriatic Arthritis

Ustekinumab, TNF Inhibitors Improve 6-Month Outcomes in Psoriatic Arthritis

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Researchers sought to evaluate the efficacy, tolerability, and persistence of TNFi and ustekinumab in patients with psoriatic arthritis initiating first-line, second-line, or third-line biologic DMARDs.

Reduced Structural Damage in Early Axial Spondyloarthritis Linked to Increased IL-31 Levels

Reduced Structural Damage in Early Axial Spondyloarthritis Linked to Increased IL-31 Levels

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Increased interleukin-31 levels may protect against structural damage in patients with axial spondyloarthritis.

Extended Disease Duration Increases Risk for IBD, Uveitis in Axial Spondyloarthritis

Extended Disease Duration Increases Risk for IBD, Uveitis in Axial Spondyloarthritis

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Axial spondyloarthritis disease duration was associated with higher risk of developing acute anterior uveitis and inflammatory bowel disease, but not psoriasis.

High Rate of Hidradenitis Suppurativa Observed in Patients With Axial Spondyloarthritis

High Rate of Hidradenitis Suppurativa Observed in Patients With Axial Spondyloarthritis

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Hidradenitis suppurativa is more common in patients with axial spondyloarthritis compared with the general population.

Certolizumab Pegol Demonstrates Positive Results in Phase 3 Trial for Nonradiographic Axial Spondyloarthritis

Certolizumab Pegol Demonstrates Positive Results in Phase 3 Trial for Nonradiographic Axial Spondyloarthritis

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Results from a phase 3 trial show that certolizumab pegol improves the signs and symptoms of nonradiographic axial spondyloarthritis compared with placebo at 52 weeks.

Incidence of Cardiovascular Events Similar in Rheumatoid Arthritis, Spondyloarthritis

Incidence of Cardiovascular Events Similar in Rheumatoid Arthritis, Spondyloarthritis

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The incidence of adverse cardiovascular events in patients with RA do not differ significantly compared with those with PsA or axSpA.

Radiographic Sacroiliitis vs MRI Structural Lesions for Axial Spondyloarthritis Classification

Radiographic Sacroiliitis vs MRI Structural Lesions for Axial Spondyloarthritis Classification

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Researchers sought to investigate the utility of adding structural MRI lesions of the sacroiliac joints to the imaging criterion of the ASAS axSpA criteria.

Sustained Clinical, Functional Improvements With Adalimumab in Axial Spondyloarthritis

Sustained Clinical, Functional Improvements With Adalimumab in Axial Spondyloarthritis

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Results from the ABILITY-1 study show sustained clinical and functional improvements with adalimumab treatment in nonradiographic axial spondyloarthritis.

Disease Activity in Axial Spondyloarthritis Generally Low, Stable During Pregnancy

Disease Activity in Axial Spondyloarthritis Generally Low, Stable During Pregnancy

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Researchers found that disease activity was highest during the second trimester of pregnancy.

Trabecular Bone Score May Predict Future Vertebral Fracture in Axial Spondyloarthritis

Trabecular Bone Score May Predict Future Vertebral Fracture in Axial Spondyloarthritis

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Researchers found that trabecular bone scores may be predictive of future vertebral fractures in patients with axial spondyloarthritis.

Comorbid Fibromyalgia and Axial Spondyloarthritis: Response to TNF Blocker Therapy

Comorbid Fibromyalgia and Axial Spondyloarthritis: Response to TNF Blocker Therapy

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Researchers sought to confirm whether concomitant fibromyalgia has a negative effect on TNF blocker response.

Adalimumab Reduces Whole-Body MRI Indices of Inflammation in axSpA

Adalimumab Reduces Whole-Body MRI Indices of Inflammation in axSpA

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Adalimumab may decrease whole-body magnetic resonance imaging indices of inflammation in both axial and peripheral joints and enthuses in axSpA.

Anti-CD74 Antibodies Have Limited Diagnostic Value in Early Axial Spondyloarthritis

Anti-CD74 Antibodies Have Limited Diagnostic Value in Early Axial Spondyloarthritis

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Anti-CD74 IgG and IgA antibodies have limited value in the diagnosis of early axial spondyloarthritis in younger patients who present with early back pain.

Adherence to Anti-TNF Blocker Recommendations in axSpA Linked to Improved Quality of Life

Adherence to Anti-TNF Blocker Recommendations in axSpA Linked to Improved Quality of Life

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Adherence to recommendations for the initiation and continuation of TNF-alpha blocker therapy in patients with axial spondyloarthritis is associated with improved quality of life.

Challenges of Targeting Remission in Axial Spondyloarthritis

Challenges of Targeting Remission in Axial Spondyloarthritis

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Current guidelines define remission as the absence of clinical and laboratory evidence of significant inflammatory disease, but the tools that are currently available are inadequate to assess clinical remission.

Functional Status in Early Axial Spondyloarthritis: The Role of Spinal Structural Damage

Functional Status in Early Axial Spondyloarthritis: The Role of Spinal Structural Damage

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Results of the GESPIC study found that structural damage in the spine and disease activity were both determinants of functional status and spine mobility in patients with early axial spondyloarthritis.

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