• Anemias

Anemias:

Indications for NASCOBAL:

Maintenance treatment in patients with pernicious anemia who are in remission after intramuscular Vit. B12 therapy and who have no nervous system involvement. Treatment of dietary, drug-induced, or malabsorption-related Vit. B12 deficiency not due to pernicious anemia. Prevention of Vit. B12 deficiency in patients with Vit. B12 requirements in excess of normal.

Adult:

Give at least 1hr before or after hot foods or liquids. Initially 1 spray (500mcg) in one nostril once weekly. Monitor response; may increase dose if serum B12 levels decline after 1 month. If levels persistently low, consider alternative formulations. Defer dose if nasal congestion, allergic rhinitis, or upper respiratory infections occur.

Children:

Not established.

Contraindications:

Cobalt hypersensitivity.

Warnings/Precautions:

Obtain hematocrit, reticulocyte count, Vit. B12, folate, and iron levels prior to initiation. May need supplemental folate or iron. Monitor B12 blood levels and peripheral blood count 1 month after initiation, 1 month after each dose adjustment, and regularly at 3–6 month intervals. Do not use for Schilling Test. Leber's optic atrophy: not recommended; consider alternatives. Suspected cyanocobalamin hypersensitivity: consider intradermal test dose of parenteral Vit. B12 prior to initiation. May mask previously unrecognized folate deficiency. Risk of hypokalemia and sudden death in severe megablastic anemia; monitor serum potassium, platelet count during therapy. May unmask polycythemia vera. Pregnancy.

Interactions:

May be antagonized by chloramphenicol (when used for treating anemia); monitor and consider alternatives if needed.

Adverse Reactions:

Infection, headache, glossitis, paresthesia, asthenia, nausea, rhinitis; anaphylaxis.

Generic Availability:

NO

How Supplied:

Single-use nasal spray (0.125mL)—4

Pricing for NASCOBAL

4 devices of 500mcg/spray carton (Qty: 1)
Appx. price $589
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