Colorectal disorders:

Indications for: PENTASA

Mildly to moderately active ulcerative colitis.

Adult Dosage:

Swallow whole; may open caps and sprinkle entire contents onto applesauce or yogurt, consume immediately. 1g four times daily for up to 8 weeks.

Children Dosage:

Not established.

PENTASA Warnings/Precautions:

Sulfasalazine allergy. Discontinue if acute intolerance syndrome is suspected. Discontinue at the 1st signs/symptoms of severe cutaneous adverse reactions. Conditions predisposing to myocarditis or pericarditis. Atopic dermatitis or eczema: may have more severe photosensitivity reactions. Nephrolithiasis. Ensure adequate hydration. Renal or hepatic impairment. Monitor renal function prior to and periodically during therapy. Elderly (monitor CBCs, platelets). Pregnancy. Nursing mothers: monitor infants.

PENTASA Classification:


PENTASA Interactions:

Increased toxicity with nephrotoxic drugs (eg, NSAIDs). Increased risk for blood disorders, bone marrow failure, and associated complications with azathioprine or 6-mercaptopurine and/or other drugs known to cause myelotoxicity. May cause elevated test results in measuring urinary normetanephrine; consider alternative assay.

Adverse Reactions:

Diarrhea, headache, nausea, abdominal pain, dyspepsia, vomiting, rash; renal impairment, acute intolerance syndrome, hypersensitivity reactions, severe cutaneous adverse reactions (eg, SJS, TEN, DRESS, AGEP).

Generic Drug Availability:


How Supplied:

Caps 250mg—240; 500mg—120

Pricing for PENTASA

500mg capsule (Qty: 240)
Appx. price $1441