General Rheumatology

Phosphatidylinositol 3-Kinase Delta: A Potential Target Pathway in Sjogren Syndrome

Phosphatidylinositol 3-Kinase Delta: A Potential Target Pathway in Sjogren Syndrome

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Data show that the phosphatidylinositol 3-kinase delta isoform pathway is active in Sjogren syndrome.

PAH: An Under-Recognized Complication of Adult-Onset Still's Disease

PAH: An Under-Recognized Complication of Adult-Onset Still's Disease

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PAH is an under-diagnosed complication of adult-onset Still disease.

Risk Factors for Repeat Surgery Identified in Septic Arthritis of the Hip

Risk Factors for Repeat Surgery Identified in Septic Arthritis of the Hip

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Investigators identified risk factors for repeat surgical intervention after initial arthrotomy for presumed septic arthritis of the hip.

DAPT Effective, Safe for Prophylaxis of Arterial Thrombosis in Antiphospholipid Syndrome

DAPT Effective, Safe for Prophylaxis of Arterial Thrombosis in Antiphospholipid Syndrome

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Dual antiplatelet therapy may be effective for the prophylaxis of recurrent arterial thrombosis in patients with antiphospholipid syndrome.

Efficacy of Low-Dose Interleukin-2 Examined Across Autoimmune Diseases

Efficacy of Low-Dose Interleukin-2 Examined Across Autoimmune Diseases

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Researchers assessed the safety, biologic, and clinical effects of low-dose interleukin-2 across 11 individual diseases chosen to represent the whole spectrum of autoimmune or inflammatory chronic diseases.

TNFi Treatment Patterns Examined Among Pregnant Women

TNFi Treatment Patterns Examined Among Pregnant Women

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Using a validated claims-based algorithm, study authors identified pregnancies among women 15-54 years of age from the US Sentinel System between January 1 2004 and September 30 2015.

Synovial Biopsy Analysis in Rheumatic Disease: Consensus Items Developed by EULAR, OMERACT

Synovial Biopsy Analysis in Rheumatic Disease: Consensus Items Developed by EULAR, OMERACT

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A set of analysis items has been developed by the EULAR Synovitis Study Group and the OMERACT Synovial Tissue Biopsy Group for the analysis of synovial biopsies in rheumatic diseases.

Assessing Comorbidity Prevalence Among Patients With Polymyalgia Rheumatica

Assessing Comorbidity Prevalence Among Patients With Polymyalgia Rheumatica

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Researchers conducted a systematic review to examine the existing literature on comorbidities associated with PMR.

Immunogenicity of Golimumab Validated Using Novel Anti-Drug Antibody Detection Assay

Immunogenicity of Golimumab Validated Using Novel Anti-Drug Antibody Detection Assay

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Antidrug antibody incidence was higher using drug-tolerant vs original enzyme immunoassays in patients treated with golimumab.

Single-Dose Prefilled Autoinjector for Actemra Approved

Single-Dose Prefilled Autoinjector for Actemra Approved

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Genentech announced that the FDA has approved ACTPen autoinjector for Actemra as a new formulation for adults with moderate to severe active RA.

Higher Biologic Drug Survival in JIA With Younger Age at Treatment Initiation

Higher Biologic Drug Survival in JIA With Younger Age at Treatment Initiation

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Rates of biologic drug survival and suspension by remission were both higher in those who initiated biologic treatment at <16 years.

Rituximab May Be Effective in Children With Treatment-Resistant Juvenile Idiopathic Arthritis

Rituximab May Be Effective in Children With Treatment-Resistant Juvenile Idiopathic Arthritis

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Rituximab may be an effective treatment option for many patients with juvenile idiopathic arthritis who did not respond to other therapies.

Determining Risk for New-Onset Uveitis in Juvenile Idiopathic Arthritis

Determining Risk for New-Onset Uveitis in Juvenile Idiopathic Arthritis

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Researchers sought to quantify the annual incidence of new-onset uveitis following JIA diagnosis and identify associated risk factors.

Psychological Flexibility Improves Resilience in Children With Juvenile Idiopathic Arthritis and Their Parents

Psychological Flexibility Improves Resilience in Children With Juvenile Idiopathic Arthritis and Their Parents

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Psychological flexibility in children with juvenile idiopathic arthritis and in their parents may represent resilience factors for dealing with pain and disability associated with the condition.

Canakinumab Treatment Led to Substantial Glucocorticoid Reduction in JIA

Canakinumab Treatment Led to Substantial Glucocorticoid Reduction in JIA

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Researchers evaluated the long-term efficacy and safety of canakinumab in patients with active systemic juvenile idiopathic arthritis.

Study: Cold Weather Joint Pain and Other Weather-Related Pain

Study: Cold Weather Joint Pain and Other Weather-Related Pain

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Fact or folktale: do weather patterns affect joint pain? A team of researchers set out to find the answer.

Humira Approved for the Treatment of Pediatric Uveitis

Humira Approved for the Treatment of Pediatric Uveitis

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The approval was based on data from a randomized, double-masked, placebo-controlled study of 90 pediatric patients aged 2 to < 18 years with active JIA-associated non-infectious uveitis.

Clinical Features Identified for Localized Scleroderma in Children

Clinical Features Identified for Localized Scleroderma in Children

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Researchers conducted a multicenter prospective study to identify clinical features characteristic of localized scleroderma in children.

Original vs Expanded Disease Activity Scoring System in JIA Examined

Original vs Expanded Disease Activity Scoring System in JIA Examined

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For a more precise assessment of disease activity and treatment effectiveness in individuals with JIA, inclusion of MCP joints should be considered in the scoring system.

Tacrolimus Possibly Beneficial Long Term in Lupus Nephritis

Tacrolimus Possibly Beneficial Long Term in Lupus Nephritis

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Over a 5-year period, the drug was well tolerated and associated with significant declines in urinary protein-creatinine ratio and mean prednisolone dose.

Transitioning to Adult Health Care: Predictors of Preparedness in Adolescents With Arthritis

Transitioning to Adult Health Care: Predictors of Preparedness in Adolescents With Arthritis

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Female gender, older age, and higher patient activation scores predicted transition readiness in adolescent patients with arthritis.

Juvenile Spondyloarthritis Disease Activity Index Valid in Children With Enthesitis-Related Arthritis

Juvenile Spondyloarthritis Disease Activity Index Valid in Children With Enthesitis-Related Arthritis

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The Juvenile Spondyloarthritis Disease Activity Index is an appropriate measure of disease activity for enthesitis-related arthritis.

Childhood-Onset Systemic Lupus Erythematosus Negatively Affects Quality of Life in Adulthood

Childhood-Onset Systemic Lupus Erythematosus Negatively Affects Quality of Life in Adulthood

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Childhood-onset SLE has major effects on quality of life in adulthood.

Actemra SC Approved to Treat Active Systemic JIA

Actemra SC Approved to Treat Active Systemic JIA

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The FDA has approved Actemra SC for the treatment of active systemic JIA alone or in combination with methotrexate in patients ‚Č•2 years old.

Evaluating Disease Activity Outcome Variables in Juvenile Dermatomyositis

Evaluating Disease Activity Outcome Variables in Juvenile Dermatomyositis

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The signs and symptoms associated with disease activity in juvenile dermatomyositis could be used to stratify patients and adapt treatment plans.

Juvenile Spondyloarthritis: Classification and Treatment Considerations

Juvenile Spondyloarthritis: Classification and Treatment Considerations

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Juvenile spondyloarthritis is a distinct form of childhood arthritis because of the male predominance, later age of onset, and involvement of the entheses and axial skeleton.

Ocular Complication Rates Improved With Biologic Use in Noninfectious Pediatric Uveitis

Ocular Complication Rates Improved With Biologic Use in Noninfectious Pediatric Uveitis

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Improvements in the rate of ocular complications and visual impairment have been noted in pediatric patients with noninfectious uveitis who are treated with biologic agents.

Examining Gaps in Mental Health Care Among Youth With Juvenile Rheumatic Disease

Examining Gaps in Mental Health Care Among Youth With Juvenile Rheumatic Disease

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There is an unmet need for mental health interventions that address illness-related issues affecting youth with rheumatologic conditions.

Diagnosing Lyme Disease in Children With Neuropsychiatric Illness

Diagnosing Lyme Disease in Children With Neuropsychiatric Illness

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Health professionals from many disciplines need to be able to recognize the clinical presentations, essential diagnostic tests, and treatment approach of Lyme neuroborreliosis.

Low Nailfold Capillary Density Associated With Lung Involvement in Juvenile Dermatomyositis

Low Nailfold Capillary Density Associated With Lung Involvement in Juvenile Dermatomyositis

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Low nailfold capillary density is associated with impaired pulmonary function tests and more frequent high-resolution computed tomography abnormalities in patients with juvenile dermatomyositis.

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