Gout News Archive

Gout Increases Risk for Chronic Kidney Disease

Gout Increases Risk for Chronic Kidney Disease

Gout may be a risk factor for the development of CKD stage ≥3.

Allopurinol Linked to Reduced Risk for CKD Stage ≥3 in Gout

Allopurinol Linked to Reduced Risk for CKD Stage ≥3 in Gout

For patients with gout, allopurinol is associated with a reduced risk for developing chronic kidney disease stage ≥3.

Panel Issues Consensus Statement on Management of Gouty Arthritis of the Foot and Ankle

Panel Issues Consensus Statement on Management of Gouty Arthritis of the Foot and Ankle

An expert panel evaluated 23 separate statements related to the etiology, diagnosis, and treatment of gout.

High Gout Burden Found Among Solid Organ Transplant Recipients

High Gout Burden Found Among Solid Organ Transplant Recipients

Study reveals an 11% prevalence of active gout among solid organ transplant recipients overall and a 13% prevalence among kidney transplant recipients.

Ultrasound Reveals Decreased Urate Deposits After Urate-Lowering Therapy in Gout

Ultrasound Reveals Decreased Urate Deposits After Urate-Lowering Therapy in Gout

Ultrasound can show decreased urate deposition after urate lowering therapy.

Gout Outcomes Improved With Nurse-Led Care

Gout Outcomes Improved With Nurse-Led Care

In a British study, nurse-led care emphasizing patient education and engagement significantly improved the proportion of gout sufferers who achieved target serum urate levels.

Increased Levels of Plasma Leukotriene B4 Found in Acute Gout

Increased Levels of Plasma Leukotriene B4 Found in Acute Gout

The plasma level of leukotriene B4 was increased in patients with acute gout.

Diet Less Important Than Genes for High Serum Urate Levels

Diet Less Important Than Genes for High Serum Urate Levels

Diet explains little of the variation in serum urate levels in the general population, while genetic factors make a greater contribution.

Ultrasound Can Reveal Renal Medulla Urate Deposits in Tophaceous Gout

Ultrasound Can Reveal Renal Medulla Urate Deposits in Tophaceous Gout

Ultrasound examination may be used to detect crystal deposition in the renal medulla in patients with tophaceous gout.

Examining Referral Patterns for DECT in Diagnosis, Management of Gout

Examining Referral Patterns for DECT in Diagnosis, Management of Gout

Researchers examined the use of dual-energy computed tomography gout imaging in clinical practice from 2007 to 2016.

Monosodium Urate Measured With DECT Predicts Risk for Flare in Gout

Monosodium Urate Measured With DECT Predicts Risk for Flare in Gout

The extent of monosodium urate burden measured with dual-energy computed tomography can predict the risk for disease flares in patients with gout.

Routine Knee, Metatarsophalangeal Joint Examination May Improve Gout Diagnosis

Routine Knee, Metatarsophalangeal Joint Examination May Improve Gout Diagnosis

Researchers evaluated the distribution of ultrasound features of lower-limb joints and the risk factors of tophus in patients with gout.

Clinical Gout-Related Benefits Not Demonstrated With Lesinurad Combination Therapy

Clinical Gout-Related Benefits Not Demonstrated With Lesinurad Combination Therapy

Although a combination of lesinurad 200 mg and xanthine oxidase inhibitor therapy was effective and well-tolerated among patients with gout, clinical gout-related benefits were not improved.

Patients With Obstructive Sleep Apnea Have Increased Risk for Gout

Patients With Obstructive Sleep Apnea Have Increased Risk for Gout

People with obstructive sleep apnea continued to be at higher risk of developing gout after the first year of obstructive sleep apnea diagnosis.

Gout Attack Risk Lowered With Interleukin-1ß Blockade

Gout Attack Risk Lowered With Interleukin-1ß Blockade

Inhibition of IL-1ß with canakinumab significantly decreased gout attack risk at all baseline serum uric acid (SUA) levels and without changing SUA levels.

Limited Evidence for Teratogenicity of Allopurinol Use During Pregnancy

Limited Evidence for Teratogenicity of Allopurinol Use During Pregnancy

Researchers found insufficient evidence of teratogenicity for allopurinol taken prior to or during pregnancy.

Patients With Gout Have Lower Prevalence of Colorectal Cancer

Patients With Gout Have Lower Prevalence of Colorectal Cancer

The 10-year prevalence of colonoscopy-documented colorectal cancer was 0.8% among gout patients vs 3.7% among osteoarthritis patients.

Gout Linked to Increased Risk for Hearing Loss in the Elderly

Gout Linked to Increased Risk for Hearing Loss in the Elderly

Gout was associated with a higher risk of developing hearing loss in older adults.

Urate Levels Predict Long-Term Gout Risk

Urate Levels Predict Long-Term Gout Risk

In a large Swedish study of middle-aged individuals, increments in baseline serum urate levels were associated with progressively increased risks of gout over a mean 28 years of follow-up.

Long-Term Safety Data Raise No New Concerns for Approved Lesinurad Dose in Gout

Long-Term Safety Data Raise No New Concerns for Approved Lesinurad Dose in Gout

Treating patients with gout with lesinurad 200 mg and xanthine oxidase inhibitors for 24 months revealed no new safety concerns.

Inadequate Response to Allopurinol Dose Escalation Associated With Younger Age, Low Adherence

Inadequate Response to Allopurinol Dose Escalation Associated With Younger Age, Low Adherence

A minority of people with gout never reach target serum urate levels when allopurinol dose is increased in a treat-to-target manner.

Elevated Ferritin Levels Associated With Risk for Gout, Flare Frequency

Elevated Ferritin Levels Associated With Risk for Gout, Flare Frequency

Increased ferritin levels were associated with gout and flare frequency.

Obesity Associated With Increased Risk for Gout, Higher Serum Urate Concentrations

Obesity Associated With Increased Risk for Gout, Higher Serum Urate Concentrations

Overall obesity is associated with an increased risk for gout and with higher serum urate concentrations.

Urate-Lowering Therapy May Not Mediate Arthroplasty Risk in Gout

Urate-Lowering Therapy May Not Mediate Arthroplasty Risk in Gout

Patients with gout have an increased risk for total joint replacement, which may not be reduced by urate-lowering treatment.

Extended-Release vs Immediate-Release Febuxostat in Gout With Renal Impairment

Extended-Release vs Immediate-Release Febuxostat in Gout With Renal Impairment

Researchers assessed the efficacy and safety of febuxostat extended release and immediate release in patients with gout and normal or impaired renal function.

Gout Increases Atrial Fibrillation Risk in the Elderly

Gout Increases Atrial Fibrillation Risk in the Elderly

A study of Medicare patients found that atrial fibrillation was nearly twice as likely to develop in those with vs without gout.

Patients With Early-Onset Gout Develop Earlier Metabolic Comorbidities, Severe Joint Involvement

Patients With Early-Onset Gout Develop Earlier Metabolic Comorbidities, Severe Joint Involvement

Patients with early-onset gout experience more severe acute joint involvement and earlier metabolic comorbidities than those with common gout.

Gout Associated With Increased Risk of Developing Erectile Dysfunction

Gout Associated With Increased Risk of Developing Erectile Dysfunction

Data show that gout is associated with an increased risk of developing erectile dysfunction.

Hospitalization Increases Risk for Acute Gout Flares

Hospitalization Increases Risk for Acute Gout Flares

Researchers sought to assess the risk for in-hospital gout flares in patients with gout.

Both High and Low Uric Acid Levels Tied to Higher Mortality

Both High and Low Uric Acid Levels Tied to Higher Mortality

Both high and low uric acid levels are associated with an increased risk for mortality.

Emergency Department Visits for Gout Rise Dramatically

Emergency Department Visits for Gout Rise Dramatically

A study documents a 27% increase in visits to emergency departments for a primary diagnosis of acute gout from 2006 to 2014.

Genetically High Plasma Vitamin C Not Associated With Risk for Hyperuricemia

Genetically High Plasma Vitamin C Not Associated With Risk for Hyperuricemia

Data suggest that vitamin C supplementation should not be recommended to lower plasma urate.

Medication Adherence Low in Patients With Gout Initiating Allopurinol Therapy

Medication Adherence Low in Patients With Gout Initiating Allopurinol Therapy

Medication adherence also remained low in patients who reinitiate treatment after a gap in therapy.

Similar Cardiovascular Risk Reported in Patients Initiating Febuxostat vs Allopurinol

Similar Cardiovascular Risk Reported in Patients Initiating Febuxostat vs Allopurinol

Recent data showed no difference in the risk for myocardial infarction, stroke, new-onset heart failure, coronary revascularization, or all-cause mortality between patients initiating febuxostat compared with allopurinol.

Febuxostat vs Allopurinol in Gout: Assessing the Implications of CV Safety

Febuxostat vs Allopurinol in Gout: Assessing the Implications of CV Safety

The FDA recently issued a public safety alert in response to the results of CARES trial, which showed increased CV and all-cause mortality in patients with gout and established CVD who were treated with febuxostat therapy.

Monosodium Urate Crystal Deposits Common in Asymptomatic Sons of Individuals With Gout

Monosodium Urate Crystal Deposits Common in Asymptomatic Sons of Individuals With Gout

Asymptomatic sons of people with gout frequently have hyperuricemia and monosodium urate crystal deposits.

DECT Superior to Ultrasound for Identification of Gouty Knee Arthritis

DECT Superior to Ultrasound for Identification of Gouty Knee Arthritis

Dual-energy computed tomography was superior to ultrasound for diagnosing suspected gouty knee arthritis.

Gout, Urate-Lowering Therapy Not Associated With Risk for Fragility Fracture

Gout, Urate-Lowering Therapy Not Associated With Risk for Fragility Fracture

The use of urate-lowering therapy in patients with gout had neither beneficial nor adverse effects on long-term fracture risk.

Pegloticase Retreatment Effective for Gout After Gap in Therapy

Pegloticase Retreatment Effective for Gout After Gap in Therapy

The study authors retrospectively analyzed the charts of 4 chronic gout patients from a practice-based rheumatology clinic.

Incident Gout Risk, Serum Urate, and Comorbidities: What Are the Links?

Incident Gout Risk, Serum Urate, and Comorbidities: What Are the Links?

Ethnicity and hypertension have an association with incident gout that is not fully explained by differences in serum urate.

Crystal-Proven Gout, Gout Severity Factors Linked to Cardiovascular Disease

Crystal-Proven Gout, Gout Severity Factors Linked to Cardiovascular Disease

Investigators sought to examine the prevalence of CVD in patients with crystal-proven gout compared with control patients with arthritis.

Racial Variations Linked to Risk for Allopurinol-Associated Adverse Reactions

Racial Variations Linked to Risk for Allopurinol-Associated Adverse Reactions

Researchers found that the overall risk for hospitalization due to allopurinol-associated severe cutaneous adverse reactions is rare.

Corticosteroids May Be an Effective Alternative to NSAIDs in Acute Gout Pain

Corticosteroids May Be an Effective Alternative to NSAIDs in Acute Gout Pain

Corticosteroids appear to be a reasonable alternative to NSAIDs for the treatment of acute pain as a result of gout.

Fenofibrate Decreases Plasma Uric Acid Concentration, Gout Events in T2D

Fenofibrate Decreases Plasma Uric Acid Concentration, Gout Events in T2D

Fenofibrate may be a valuable adjunct therapy in type 2 diabetes to reduce the burden of gout.

Allopurinol Dose Escalation May Not Improve Survival in Patients With Gout

Allopurinol Dose Escalation May Not Improve Survival in Patients With Gout

Investigators sought to determine whether allopurinol dose escalation is associated with all-cause mortality.

Ultrasound Reliably Identifies Calcium Pyrophosphate Deposition Disease

Ultrasound Reliably Identifies Calcium Pyrophosphate Deposition Disease

Ultrasound is a reliable diagnostic tool for identifying calcium pyrophosphate deposition disease.

Febuxostat vs Allopurinol Evaluated in Patients With Gout, CVD

Febuxostat vs Allopurinol Evaluated in Patients With Gout, CVD

Febuxostat is noninferior to allopurinol for rates of adverse CV events but is associated with higher all-cause and CV mortality in patients with gout and CVD.

Development of Clinically Evident Gout: A Closer Look at Elevated Serum Urate Levels

Development of Clinically Evident Gout: A Closer Look at Elevated Serum Urate Levels

Serum urate level is a strong predictor of incident gout, but only about half of patients with hyperuricemia develop clinically evident gout.

Elevated Serum Uric Acid Levels May Increase Risk for Dementia in Older Adults

Elevated Serum Uric Acid Levels May Increase Risk for Dementia in Older Adults

Risk for dementia may be increased with high serum uric acid levels in elderly individuals.

Higher Monosodium Urate Crystal Depositions With Greater Disease Severity in Allopurinol-Treated Gout

Higher Monosodium Urate Crystal Depositions With Greater Disease Severity in Allopurinol-Treated Gout

In patients with gout who are treated with allopurinol, monosodium urate crystal depositions are higher with evidence of greater disease severity.

Febuxostat Lowers Blood Pressure in Patients With Hyperuricemia and Hypertension

Febuxostat Lowers Blood Pressure in Patients With Hyperuricemia and Hypertension

Febuxostat may lower blood pressure in patients with hyperuricemia, hypertension, and normal renal function.

Allopurinol Use May Lower Risk for Peripheral Arterial Disease

Allopurinol Use May Lower Risk for Peripheral Arterial Disease

New allopurinol use was associated with a reduced risk of incident peripheral arterial disease.

Gout Flares Reduced by Febuxostat Increase Plus Low-Dose Colchicine

Gout Flares Reduced by Febuxostat Increase Plus Low-Dose Colchicine

A stepwise dose increase in febuxostat plus low-dose colchicine prophylaxis was effective in the reduction of gout flares compared with febuxostat alone.

Metoprolol Elevates Serum Uric Acid and Gout Risk in African Americans

Metoprolol Elevates Serum Uric Acid and Gout Risk in African Americans

As the risk of developing gout is high in patients with hypertension, management of serum uric acid levels may improve patient outcomes.

Gout Increases Incident Stroke Risk by the Same Magnitude as Diabetes

Gout Increases Incident Stroke Risk by the Same Magnitude as Diabetes

A recent study assessed whether gout is a cardiovascular risk equivalent for stroke and myocardial infarction, similar to diabetes.

FDA Alert: Febuxostat May Increase Risk of Heart-Related Adverse Events, Death

FDA Alert: Febuxostat May Increase Risk of Heart-Related Adverse Events, Death

Gout medication febuxostat (Uloric) was associated with an increased risk of heart-related death and death from all causes.

High-Dose Lesinurad Deemed Unsuitable as Monotherapy for Gout

High-Dose Lesinurad Deemed Unsuitable as Monotherapy for Gout

Despite rapidly lowering serum uric acid levels, lesinurad cannot be recommended alone at 400 mg per day, due to substantial adverse events.

FDA Approves Duzallo for Hyperuricemia Associated With Uncontrolled Gout

FDA Approves Duzallo for Hyperuricemia Associated With Uncontrolled Gout

The US FDA has approved a new fixed-dose and dual-mechanism treatment option for uncontrolled gout.

High Levels of Serum Uric Acid May Increase Risk for Dementia in the Elderly

High Levels of Serum Uric Acid May Increase Risk for Dementia in the Elderly

Older adults with high serum uric acid levels might be at increased risk of developing vascular or mixed dementia.

Lesinurad, Febuxostat Combination Treatment Improves Tophaceous Gout Symptoms

Lesinurad, Febuxostat Combination Treatment Improves Tophaceous Gout Symptoms

Patients with tophaceous gout undergoing combination therapy with lesinurad and febuxostat showed a greater degree of symptom resolution than with febuxostat monotherapy.

Recall: Gout Pills Found in Platelet Inhibitor Sample Bottle

Recall: Gout Pills Found in Platelet Inhibitor Sample Bottle

Accidental patient dosing with Zurampic can potentially cause adverse renal effects such as acute renal failure; this is more common if Zurampic is given alone without a xanthine oxidase inhibitor.

Analysis of Factors Improving Rx Adherence in Patients with Gout

Analysis of Factors Improving Rx Adherence in Patients with Gout

Belief about medicines, presence of comorbidity, and being married positively influence adherence to medication.

DASH Diet May Help Lower Occurrence of Gout

DASH Diet May Help Lower Occurrence of Gout

Following the diet may be a good option for patients who prefer to avoid medication.

Low Serum Uric Acid Levels Significantly Reduce Gout Risk

Low Serum Uric Acid Levels Significantly Reduce Gout Risk

Reduced levels of serum uric acid are associated with markedly fewer new-onset gout and gout flares.

Age, Tophi Linked to Mortality in Gout

Age, Tophi Linked to Mortality in Gout

The presence of tophi at baseline was associated with an almost 3-fold increased risk for death from all causes.

Systematic Review Analyzes Antihypertensive Effects of Hyperuricemia Pharmacotherapy

Systematic Review Analyzes Antihypertensive Effects of Hyperuricemia Pharmacotherapy

There was low quality evidence from three trials indicating no reduction in systolic (-6.2mmHg, 95% CI: -12.8 to 0.5) or diastolic (-3.9mmHg, 95% CI: -9.2 to 1.4) 24-hour ambulatory BP with uric acid lowering drugs vs. placebo.

Allopurinol Use In Concomitant Gout and Diabetes Lowers Cardiovascular Event Risk

Allopurinol Use In Concomitant Gout and Diabetes Lowers Cardiovascular Event Risk

Study analyzes insurance claims data to examine the relationship between allopurinol use in patients with both gout and diabetes and its effect on cardiovascular event risk.

Do Risk Prediction Tools Underestimate Incidence of Carotid Plaque in Gout?

Do Risk Prediction Tools Underestimate Incidence of Carotid Plaque in Gout?

Study evaluated cardiovascular risk in patients with a new diagnosis of gout using risk prediction tools and carotid ultrasound.

Gout Associated With Increased Hip Fracture Risk in Women

Gout Associated With Increased Hip Fracture Risk in Women

Prospective study examines women with a history of gout and risk of hip and wrist fractures.

Fixed-Dose Combination Drug for Hyperuricemia Accepted for Review by FDA

Fixed-Dose Combination Drug for Hyperuricemia Accepted for Review by FDA

The Food and Drug Administration (FDA) has accepted for review the New Drug Application (NDA) for Duzallo (lesinurad/allopurinol fixed-dose combination; Ironwood) for the treatment of hyperuricemia in patients with uncontrolled gout.

Sound Bite: Clinician Researcher Discusses Newly Available Lesinurad Data

Sound Bite: Clinician Researcher Discusses Newly Available Lesinurad Data

Puja Paul Khanna, MD, MPH, sat down with Rheumatology Advisor to discuss the safety profile of lesinurad.

Should Febuxostat Be Used in Patients With Prior Skin Reaction to Allopurinol?

Should Febuxostat Be Used in Patients With Prior Skin Reaction to Allopurinol?

A study found that 1 in 5 patients with history of prior skin reaction to allopurinol also developed similar reaction after febuxostat treatment.

ACP Updates Gout Guidelines: Abandoning Treat-To-Target?

ACP Updates Gout Guidelines: Abandoning Treat-To-Target?

The guidelines recommend treatment strategies and state that evidence is insufficient to support therapy to lower uric acid to target levels.

Diagnostic Sensitivity of Ultrasound vs Crystal Analysis for Gout

Diagnostic Sensitivity of Ultrasound vs Crystal Analysis for Gout

The use of ultrasound for gout diagnosis was found to have high specificity and modest sensitivity.

Meta-analysis Supports Development of ACP Gout Practice Guidelines

Meta-analysis Supports Development of ACP Gout Practice Guidelines

A treatment review for acute gout attacks and management has found strong evidence that colchicine, NSAIDs, and corticosteroids are effective in relieving pain in acute gout patients.

Gout Risk in Obesity Reduced With Bariatric Surgery

Gout Risk in Obesity Reduced With Bariatric Surgery

In a study of Swedish Obese Subjects participants, researchers found that bariatric surgery provided benefits above and beyond usual care for weight loss.

SUA Reduction With DASH Diet in Hyperuricemia

SUA Reduction With DASH Diet in Hyperuricemia

The Dietary Approaches to Stop Hypertension (DASH) diet effectively lower serum uric acid (SUA) in patients with hyperuricemia.

Novel Uricosuric Drug Effectively Decreases Gout Flares vs Allopurinol

Novel Uricosuric Drug Effectively Decreases Gout Flares vs Allopurinol

Arhalofenate, a novel uricosuric investigational drug, appears to be well-tolerated and significantly decreased the number of gout flares compared to allopurinol. If approved, it would be the first urate-lowering anti-flare therapy for gout.

Are Reduced SUA Levels After Weight Loss Due To Decreased Triglycerides?

Are Reduced SUA Levels After Weight Loss Due To Decreased Triglycerides?

A study recently examined the mechanisms behind the reduction in serum uric acid levels following weight loss in obese patients.

Nephroprotective Properties of Allopurinol in Older Adults

Nephroprotective Properties of Allopurinol in Older Adults

Among elderly patients included in the U.S. medicare database, allopurinol use at more than 200mg/day was associated with a lower risk of incident renal failure.

Reduced Glycemic Index Correlated With Lower Uric Acid Levels

Reduced Glycemic Index Correlated With Lower Uric Acid Levels

Glycemic index was found to be more closely tied to uric acid levels as opposeid to proportion of carbohydrates among adult patients with body mass indices (BMIs) ≥25 kg/m2.

Case Report: Postoperative Acute Gouty Arthritis Attributed to HCTZ

Case Report: Postoperative Acute Gouty Arthritis Attributed to HCTZ

A case report suggests a possible link between the use of hydrochlorothiazide and postoperative acute gouty monoarthritis.

Additional Patients at Increased Risk for SJS/TEN With Urate-Lowering Drugs

Additional Patients at Increased Risk for SJS/TEN With Urate-Lowering Drugs

There may be clinical utility in screening certain patients for the HLA-B*5801 variant prior to initiating urate-lowering therapy, to better assess risks for severe cutaneous reactions like Stevens-Johnson syndrome.

Visceral, Ectopic Liver Fat Accumulation Associated With Hyperuricemia

Visceral, Ectopic Liver Fat Accumulation Associated With Hyperuricemia

Investigators examined whether intra-abdominal fat is independently associated with hyperuricemia.

Febuxostat Well Tolerated in Gout Patients With Moderate to Severe Renal Impairment

Febuxostat Well Tolerated in Gout Patients With Moderate to Severe Renal Impairment

Patients with moderate to severe renal impairment experienced no significant deterioration in renal function over a 12-month period of treatment with febuxostat

Prednisolone for Acute Gout Provides Similar Analgesia as Indomethicin

Prednisolone for Acute Gout Provides Similar Analgesia as Indomethicin

Oral prednisolone and indomethacin had similar analgesic effectiveness among patients with acute gout. Prednisolone is an effective and safe first-line option for treatment of acute gout.

Presence of Gouty Tophi Increases Risk of Cardiovascular Disease More Than Hypertension

Presence of Gouty Tophi Increases Risk of Cardiovascular Disease More Than Hypertension

The presence of tophi in people with gout was associated with increased risk for cardiovascular disease.

Sleep Apnea Associated With Increased Risk of Incident Gout

Sleep Apnea Associated With Increased Risk of Incident Gout

Research shows that incident gout rates are higher among patients with sleep apnea.

Zurampic Approved for Gout Treatment

Zurampic Approved for Gout Treatment

Zurampic (lesinurad) has been approved—in combination with a xanthine oxidase inhibitor—to treat hyperuricemia in gout.

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