Gout

Patients With Obstructive Sleep Apnea Have Increased Risk for Gout

Patients With Obstructive Sleep Apnea Have Increased Risk for Gout

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People with obstructive sleep apnea continued to be at higher risk of developing gout after the first year of obstructive sleep apnea diagnosis.

Gout Attack Risk Lowered With Interleukin-1ß Blockade

Gout Attack Risk Lowered With Interleukin-1ß Blockade

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Inhibition of IL-1ß with canakinumab significantly decreased gout attack risk at all baseline serum uric acid (SUA) levels and without changing SUA levels.

Limited Evidence for Teratogenicity of Allopurinol Use During Pregnancy

Limited Evidence for Teratogenicity of Allopurinol Use During Pregnancy

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Researchers found insufficient evidence of teratogenicity for allopurinol taken prior to or during pregnancy.

Managing Gout in Patients Undergoing Bariatric Surgery

Managing Gout in Patients Undergoing Bariatric Surgery

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Although bariatric surgery is the most effective treatment strategy for severe obesity, there is a dearth of research regarding the effects of this procedure on patients with gout.

Patients With Gout Have Lower Prevalence of Colorectal Cancer

Patients With Gout Have Lower Prevalence of Colorectal Cancer

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The 10-year prevalence of colonoscopy-documented colorectal cancer was 0.8% among gout patients vs 3.7% among osteoarthritis patients.

Gout Linked to Increased Risk for Hearing Loss in the Elderly

Gout Linked to Increased Risk for Hearing Loss in the Elderly

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Gout was associated with a higher risk of developing hearing loss in older adults.

Urate Levels Predict Long-Term Gout Risk

Urate Levels Predict Long-Term Gout Risk

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In a large Swedish study of middle-aged individuals, increments in baseline serum urate levels were associated with progressively increased risks of gout over a mean 28 years of follow-up.

Long-Term Safety Data Raise No New Concerns for Approved Lesinurad Dose in Gout

Long-Term Safety Data Raise No New Concerns for Approved Lesinurad Dose in Gout

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Treating patients with gout with lesinurad 200 mg and xanthine oxidase inhibitors for 24 months revealed no new safety concerns.

Inadequate Response to Allopurinol Dose Escalation Associated With Younger Age, Low Adherence

Inadequate Response to Allopurinol Dose Escalation Associated With Younger Age, Low Adherence

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A minority of people with gout never reach target serum urate levels when allopurinol dose is increased in a treat-to-target manner.

Elevated Ferritin Levels Associated With Risk for Gout, Flare Frequency

Elevated Ferritin Levels Associated With Risk for Gout, Flare Frequency

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Increased ferritin levels were associated with gout and flare frequency.

Obesity Associated With Increased Risk for Gout, Higher Serum Urate Concentrations

Obesity Associated With Increased Risk for Gout, Higher Serum Urate Concentrations

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Overall obesity is associated with an increased risk for gout and with higher serum urate concentrations.

Urate-Lowering Therapy May Not Mediate Arthroplasty Risk in Gout

Urate-Lowering Therapy May Not Mediate Arthroplasty Risk in Gout

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Patients with gout have an increased risk for total joint replacement, which may not be reduced by urate-lowering treatment.

Extended-Release vs Immediate-Release Febuxostat in Gout With Renal Impairment

Extended-Release vs Immediate-Release Febuxostat in Gout With Renal Impairment

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Researchers assessed the efficacy and safety of febuxostat extended release and immediate release in patients with gout and normal or impaired renal function.

Gout Increases Atrial Fibrillation Risk in the Elderly

Gout Increases Atrial Fibrillation Risk in the Elderly

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A study of Medicare patients found that atrial fibrillation was nearly twice as likely to develop in those with vs without gout.

Patients With Early-Onset Gout Develop Earlier Metabolic Comorbidities, Severe Joint Involvement

Patients With Early-Onset Gout Develop Earlier Metabolic Comorbidities, Severe Joint Involvement

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Patients with early-onset gout experience more severe acute joint involvement and earlier metabolic comorbidities than those with common gout.

Gout Associated With Increased Risk of Developing Erectile Dysfunction

Gout Associated With Increased Risk of Developing Erectile Dysfunction

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Data show that gout is associated with an increased risk of developing erectile dysfunction.

Hospitalization Increases Risk for Acute Gout Flares

Hospitalization Increases Risk for Acute Gout Flares

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Researchers sought to assess the risk for in-hospital gout flares in patients with gout.

Both High and  Low Uric Acid Levels Tied to Higher Mortality

Both High and Low Uric Acid Levels Tied to Higher Mortality

Both high and low uric acid levels are associated with an increased risk for mortality.

Emergency Department Visits for Gout Rise Dramatically

Emergency Department Visits for Gout Rise Dramatically

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A study documents a 27% increase in visits to emergency departments for a primary diagnosis of acute gout from 2006 to 2014.

Genetically High Plasma Vitamin C Not Associated With Risk for Hyperuricemia

Genetically High Plasma Vitamin C Not Associated With Risk for Hyperuricemia

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Data suggest that vitamin C supplementation should not be recommended to lower plasma urate.

Medication Adherence Low in Patients With Gout Initiating Allopurinol Therapy

Medication Adherence Low in Patients With Gout Initiating Allopurinol Therapy

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Medication adherence also remained low in patients who reinitiate treatment after a gap in therapy.

Similar Cardiovascular Risk Reported in Patients Initiating Febuxostat vs Allopurinol

Similar Cardiovascular Risk Reported in Patients Initiating Febuxostat vs Allopurinol

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Recent data showed no difference in the risk for myocardial infarction, stroke, new-onset heart failure, coronary revascularization, or all-cause mortality between patients initiating febuxostat compared with allopurinol.

Febuxostat vs Allopurinol in Gout: Assessing the Implications of CV Safety

Febuxostat vs Allopurinol in Gout: Assessing the Implications of CV Safety

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The FDA recently issued a public safety alert in response to the results of CARES trial, which showed increased CV and all-cause mortality in patients with gout and established CVD who were treated with febuxostat therapy.

Monosodium Urate Crystal Deposits Common in Asymptomatic Sons of Individuals With Gout

Monosodium Urate Crystal Deposits Common in Asymptomatic Sons of Individuals With Gout

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Asymptomatic sons of people with gout frequently have hyperuricemia and monosodium urate crystal deposits.

DECT Superior to Ultrasound for Identification of Gouty Knee Arthritis

DECT Superior to Ultrasound for Identification of Gouty Knee Arthritis

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Dual-energy computed tomography was superior to ultrasound for diagnosing suspected gouty knee arthritis.

Allopurinol Medication Adherence Increased With Daily Text Message Reminders

Allopurinol Medication Adherence Increased With Daily Text Message Reminders

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Mobile phone text reminders could be an important tool to enhance medication adherence in people with gout.

Gout, Urate-Lowering Therapy Not Associated With Risk for Fragility Fracture

Gout, Urate-Lowering Therapy Not Associated With Risk for Fragility Fracture

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The use of urate-lowering therapy in patients with gout had neither beneficial nor adverse effects on long-term fracture risk.

Pegloticase Retreatment Effective for Gout After Gap in Therapy

Pegloticase Retreatment Effective for Gout After Gap in Therapy

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The study authors retrospectively analyzed the charts of 4 chronic gout patients from a practice-based rheumatology clinic.

Incident Gout Risk, Serum Urate, and Comorbidities: What Are the Links?

Incident Gout Risk, Serum Urate, and Comorbidities: What Are the Links?

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Ethnicity and hypertension have an association with incident gout that is not fully explained by differences in serum urate.

Crystal-Proven Gout, Gout Severity Factors Linked to Cardiovascular Disease

Crystal-Proven Gout, Gout Severity Factors Linked to Cardiovascular Disease

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Investigators sought to examine the prevalence of CVD in patients with crystal-proven gout compared with control patients with arthritis.

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