Gout Linked to Higher Risk for Incident Parkinson Disease in Older Adults

illustration of the neural pathways that come from parkinon's disease
illustration of the neural pathways that come from parkinon’s disease
Gout may be associated with a higher risk for incident PD in older adults.

The following article is part of conference coverage from the 2018 American College of Rheumatology and Association of Rheumatology Health Professionals (ACR/ARHP) Annual Meeting in Chicago, Illinois. Rheumatology Advisor’s staff will be reporting breaking news associated with research conducted by leading experts in rheumatology. Check back for the latest news from ACR/ARHP 2018 .

CHICAGO —There may be a link between gout and incident Parkinson disease, especially in older adults, according to a recent study presented at the 2018 ACR/ARHP Annual Meeting, held October 19-24, 2018, in Chicago, Illinois.

Researchers from the University of Alabama at Birmingham culled relevant participants from the 5% Medicare claims data between 2006 and 2012 to examine the relationship between gout and incident Parkinson disease. The cohort study included 1.72 million people with a mean age of 75 years and a mean Charlson-Romano comorbidity index score of 1.60 (SD, 2.39). The participants were 58% female and 86% white.

Of the participants, 22,636 people developed incident Parkinson disease during follow-up. Gout was linked to an increased risk of Parkinson disease in the main analysis at a hazard ratio of 1.14 (95% CI, 1.07-1.21).

Sensitivity analyses supported these findings. Gender and race differences did not appear to be factors. However, risk varied to some extent by age. Participants between 65 and 75, between 75 and 85, and over 85 had respective hazard ratios of incident Parkinson disease with gout of 1.27 (95% CI, 1.16-1.39), 1.07 (95% CI, 0.97-1.16), and 0.97 (95% CI, 0.79- 1.20).

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In closing, the researchers expressed that the strongest link between gout and Parkinson disease was discovered in individuals between the ages of 65 and 75 years compared with other age groups.

They suggested that “mechanisms of this increased risk need to be evaluated in future studies.”

J. A. Singh declares affiliations with the pharmaceutical industry. Please refer to reference for a complete list of his disclosures.

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Singh JA, Cleveland J. Gout and the risk of Parkinson’s disease in older adults: a study of U.S. Medicare data. Presented at: 2018 ACR/ARHP Annual Meeting; October 19-24, 2018; Chicago, IL. Abstract 1298.

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