The following article is a part of conference coverage from the American Society for Bone and Mineral Research (ASBMR) 2020 Annual Meeting, held virtually from September 11 to 15, 2020. The team at Rheumatology Advisor will be reporting on the latest news and research conducted by leading experts in rheumatology. Check back for more from the ASBMR 2020 Annual Meeting.
Vitamin D deficiency in patients with spondyloarthritis is associated with increased inflammatory activity, according to study data presented at the American Society for Bone and Mineral Research (ASBMR) Annual Meeting, held virtually from September 11 to 15, 2020.
A case-control retrospective study was conducted with patients with spondyloarthritis who received treatment at the outpatient rheumatology clinics of a tertiary hospital in Ciudad Real, Spain, between June 2018 and June 2019. Vitamin D levels were calculated through routine clinical examinations. Disease activity was determined using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and the Disease Activity in Psoriatic Arthritis (DAPSA) score. BASDAI and DAPSA values >4 were considered to represent significant inflammatory activity. Logistic regression was used to determine the influence of vitamin D deficiency on disease activity and inflammation.
The study cohort included 115 patients with mean age 45.97±13.41 years, among whom 64 (56%) were men. The most common diagnoses were ankylosing spondylitis (47%), psoriatic arthropathy (21%), and undifferentiated spondyloarthritis (16%). Mean disease activity was a BASDAI score of 4.57±2.35 and a DAPSA score of 12.61±6.76. Overall, 77.4% of patients had vitamin D deficiency or insufficiency. In regression models, vitamin D deficiency or insufficiency was significantly associated with having a BASDAI or DAPSA score >4 (odds ratio [OR], 10; 95% CI, 3.66-27.29; P <.0001). Vitamin D deficiency and insufficiency was also associated with elevated erythrocyte sedimentation rate (OR, 2.76; 95% CI, 1.09-7.00; P =.0438).
According to these data, vitamin D levels may be associated with increased inflammatory activity in patients with spondyloarthritis.
The researcher concluded that maintaining adequate vitamin D levels may be important in improving clinical presentation of spondyloarthritis.
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Corredor DC. The levels of vitamin D in the spondyloarthritis. Does the deficit correspond to the inflammatory activity? Presented at: ASBMR 2020 Virtual Annual Meeting; September 11-15, 2020. #Poster P-344.