Increased Risk for Chronic Kidney Disease in Rheumatoid Arthritis

human kidney cross section
human kidney cross section
Patients with rheumatoid arthritis may have a significantly higher risk of developing chronic kidney disease.

The following article is part of conference coverage from the 2018 American College of Rheumatology and Association of Rheumatology Health Professionals (ACR/ARHP) Annual Meeting in Chicago, Illinois. Rheumatology Advisor’s staff will be reporting breaking news associated with research conducted by leading experts in rheumatology. Check back for the latest news from ACR/ARHP 2018 .

CHICAGO — Patients with rheumatoid arthritis (RA) are at a significantly higher risk of developing chronic kidney disease than the general population, according to data from a meta-analysis presented at the 2018 ACR/ARHP Annual Meeting, held October 19- 24, 2018, in Chicago, Illinois.

Researchers used MEDLINE and EMBASE databases to search for all retrospective or prospective cohort studies that evaluated the risk differences of developing chronic kidney disease between patients with RA and the general population. The review found 4 retrospective studies, with a total of 1,627,981 participants, that met the inclusion criteria.

Using the DerSimonian and Laird random-effects pooling method, the point estimates and standard errors from these 4 studies were combined to reveal that patients with RA had a significant increased risk of developing chronic kidney disease (risk ratio, 1.52; CI 95%, 1.28-1.80). A funnel plot suggested there was not a publication bias, and the percentage of variation across the studies was high at 82%.

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The researchers concluded that patients with RA were at an increased risk of developing chronic kidney disease.


Ungprasert P, Raksasuk S. Increased risk of incident chronic kidney disease among patients with rheumatoid arthritis: a systematic review and meta-analysis of cohort studies. Presented at: 2018 ACR/ARHP Annual Meeting; October 19-24, 2018; Chicago, IL. Abstract 537.

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