General Rheumatology

Novel Therapy for Prosthetic Joint Infections Gets Orphan Drug Status

The FDA has granted Orphan Drug designation to TNP-2092 (TenNor Therapeutics) powder for intravenous IV injection for the treatment of prosthetic joint infections.

Mental Distress, Depression Prevalent in Adults With Arthritis

The prevalence of mental distress is 16.8 percent and the prevalence of depression is 32.1 percent among adults with arthritis.

Rheumatoid Arthritis Drug Decreases Gut Leakiness, Study Says

Researchers have found that tofacitinib, a drug approved by the FDA to treat rheumatoid arthritis and ulcerative colitis, might also treat leaky gut.

Risk for Infections and Cancer With Interleukin Treatment in Rheumatologic Diseases

Interleukin (IL) therapy for the treatment of rheumatologic diseases may increase the risk for serious infections, opportunistic infections, and cancer.

Multiple Fracture-Linked Medications Increase Risk for Hip Fracture

The addition of a second and third fracture-associated drug (FAD) is associated with an increase in hip fracture risk.

Biosimilar for Adalimumab Gets FDA Approval

The Food and Drug Administration (FDA) has approved Abrilada (adalimumab-afzb; Pfizer), a biosimilar to Humira (adalimumab; AbbVie).

Weight Loss Tied to Lower Hip Bone Density in Older Adults

Obese and overweight older individuals who lose weight have lower bone mineral density (BMD) in their hips.

Cannabis Use Disorder Has Declined Among Teens, Young Adults

Contrary to expectations, the prevalence of cannabis use disorder (CUD) decreased significantly among individuals reporting daily/almost daily cannabis use between 2002 and 2016.

Serum Calcium May Have Negative Effect on Bone Mineral Density

Elevated calcium levels may lead to suboptimal growth of bone, according to the study’s findings.

Direct-Acting Antiviral Therapy Effective in Concomitant Hepatitis C Virus Infection, Rheumatic Diseases

Researchers assessed the effectiveness and safety of direct-acting antiviral therapy for patients with concomitant hepatitis C virus infection and rheumatic diseases, including rheumatoid arthritis.

Type 2 Diabetes Linked to Higher Risk for Vertebral Fractures

Individuals with type 2 diabetes (T2D) are at higher risk for sustaining an incident vertebral fracture (VF) compared with individuals without T2D.

Risk for Birth Defects Not Increased With Adalimumab

Adalimumab exposure in pregnancy does not increase the risk for birth defects.

Insufficient Evidence to Support Use of Medical Cannabis for Rheumatologic Conditions

There is insufficient evidence to support the use of medical cannabis or cannabis-related medications for the treatment of musculoskeletal and autoimmune disorders.

Interleukin Inhibitors Linked to Increased Infection, Cancer Risk in Rheumatologic Diseases

In patients with rheumatologic diseases, treatment with interleukin inhibitors may increase the risk of serious infections, opportunistic infections, and cancer, according to a systematic review and meta-analysis published in JAMA Network Open.

Interstitial Lung Disease Associated With More Muscle Mass, Less Bone Density Loss

Researchers of the study aimed to determine the differences in muscle area and bone density in patients with end-stage lung disease.