HealthDay News – Five genes may serve as biomarkers for osteoarthritis (OA) progression, according to a study published online Feb. 2 in the International Journal of Rheumatic Diseases.

Beiyue Wang, from Jinling Hospital in Nanjing, China, and colleagues conducted microarray analysis on five OA acetabular labrum samples and three healthy control samples. Differentially expressed genes (DEGs) were assessed, and functional enrichment analysis and protein-protein interaction (PPI) network analysis were conducted.

The researchers identified 141 DEGs (44 were up-regulated and 97 were down-regulated). There was significant enrichment in intracellular signal transduction function among up-regulated genes (including CDH2 and WNT5A), while down-regulated genes (such as KDR, FLT1, and CDH5) were correlated with cardiovascular system development. Striking nodes in the PPI network included FLT1, KDR, CDH2, and CDH5.


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“Intracellular signal transduction and cardiovascular system development might play significant roles in the destruction of labrum during OA progression,” the authors write.

Summary and Clinical Applicability

OA is characterized by a series of degradations of articular cartilage. Critical genes in acetabular labrum cells were identified by microarray to detect their roles in the development of OA. A total of 141 DEGs were identified between OA acetabular labrum cells. Several potential biomarkers of OA prognosis were identified, such as WNT5A, KDR, FLT1 and CDH5.  These biomarkers may serve as diagnostic tools if they are validated with further research. 

Reference

Wang B, Zhao J, Zhang P.Gene signatures in osteoarthritic acetabular labrum using microarray analysis.Int J Rheum Dis. 2016 Feb 2. doi: 10.1111/1756-185X.12810. [Epub ahead of print]