—————————————————————————————————————————————————————— Systemic lupus erythematosus (SLE) can be associated with many diagnostic challenges. Although SLE was first recognized as a systemic disease more than a century ago,1 there is still no definitive test for this complex, multisystemic, autoimmune disease.2 Instead, SLE is diagnosed based on a battery of clinical features and laboratory test results, none of…
What breakthroughs in medicine do experts expect to see in 2019 and beyond?
A 32-year-old man is referred for evaluation of an erythematous rash on his upper back that has been present for approximately 2 months. At age 25, he was diagnosed with systemic lupus erythematosus (SLE), a disease that also affects his mother. Treatment with hydroxychloroquine 200 mg/d was restarted approximately 1 month ago. Examination reveals annular,…
Many patients with antiphospholipid syndrome develop neurological disorders that appear to have a nonthrombotic pathogenesis.
A 63-year-old woman presents with left knee pain that she has had for several months. The pain is worse when going up and down stairs, and she seems to be very achy at the end of the day. She denies prior injury. Anteroposterior, lateral, and merchant view X-rays show mild joint space narrowing, subchondral sclerosis…
