Researchers found that data showed that a high percentage of black patients with rheumatoid arthritis had a cardiovascular disease factor and that about half had specific rheumatoid arthritis risk factors, such as joint erosions, elevated inflammatory markers, extra-articular disease, and body mass indexes below 20, which requires effective intervention.
Researchers created a model for general practitioners to use for patients who are atypical for detection of inflammatory arthritis, which included difficulty forming a fist, joint swelling (self-reported), between 1 and 3 painful joints, stiffness <1 hour in the morning, fewer than 6 weeks of symptom duration, male gender, and age of at least 60 years.
Researchers posit that improvement of health related quality of life should be an objectives of treatment of early arthritis and early inflammatory back pain, but their finding is that disease only explains part of the assessment of quality of life.
Researchers found data indicative of the responsiveness of combined scores for inflammation, which could be improved with normalized or weighted summation of the Outcome Measures in Rheumatology RA MRI Scoring system pathologies, rather than unweighted summation.
Investigators found that while in vivo and in vitro preclinical trials of toreforant reduced IL-17 production and arthritis disease severity, phase 2 study data showed low levels of efficacy in patients with RA.