Topics

TOPICS

ANKYLOSING SPONDYLITIS

JAK Inhibitors Efficacious, Improve Function and Well-Being Among Patients With Ankylosing Spondylitis

In a systematic review and meta-analysis, authors assessed the safety and efficacy of Janus kinase (JAK) inhibitors in the treatment of ankylosing spondylitis.

Upadacitinib Approved for Active Ankylosing Spondylitis

The approval was based on data from the phase 2/3 SELECT-AXIS 1 and the phase 3 SELECT-AXIS 2 trials.

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FIBROMYALGIA

Decreased Fibromyalgia Pain Following Sham Transcranial Direct Current Simulation

Fifteen treatments with active tDCS were superior to sham tDCS only with regards to depression and anxiety in fibromyalgia.

Enrollment in Fibromyalgia Treatment Study Ends After Disappointing Results

The phase 3 RALLY study is evaluating the efficacy and safety of TNX-102 SL in 514 adult patients with fibromyalgia.

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GOUT

Hyperuricemia With Diabetes Compounds Risks for End-Stage Kidney Disease and Death

A study conducted in Taiwan is the first to show that hyperuricemia is as risky as diabetes in contributing to ESKD and death risk in patients with stage 3 to 5 CKD.

Colchicine May Lower Risk for Chronic Kidney Disease Progression

Colchicine, a plant-derived alkaloid, has a broad range of anti-inflammatory effects that interfere with neutrophil function, according to investigators.

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LYME DISEASE

Could Lyme Disease Cause Alzheimer Disease or Lewy Body Dementia?

A team of researchers investigated whether credible evidence supporting a causal relationship between Lyme disease and Alzheimer disease or Lewy body dementia exists.

Are Prophylactic Oral Antibiotics Effective Against Lyme Disease?

Researchers conducted a meta-analysis to determine whether antibiotic prophylaxis is effective in the prevention of Lyme disease.

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CONNECTIVE TISSUE DISEASE

Celiprolol Gets Breakthrough Therapy Status for Vascular Ehlers-Danlos Syndrome

Edsivo is intended to help patients with vEDS by promoting normal collagen synthesis in the blood vessels, and by shifting the pressure load away from the vessels most prone to dissection and rupture.

Case Report: Baricitinib Successfully Treats Refractory Eosinophilic Fasciitis

Authors report on the case of a patient who was diagnosed with eosinophilic fasciitis that was successfully treated with baricitinib.

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OSTEOARTHRITIS

Hyaluronic Acid and Dextrose Coinjections Improve Knee Osteoarthritis Symptoms

Researchers investigated whether intra-articular coinjection with hypertonic dextrose improves hyaluronic acid therapy outcomes for patients with knee osteoarthritis.

Mat Pilates Improves Pain, Functionality Among Older Women With Knee Osteoarthritis

Researchers evaluated the effects of mat Pilates on health status, pain, stiffness, and functionality among older adult women with knee osteoarthritis.

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OSTEOPOROSIS

Eating 6 Prunes a Day Prevents Bone Loss in Patients With Osteoporosis

Eating prunes daily may protect against bone loss, osteoporosis in postmenopausal women.

Alendronate Protects Against Bone Loss in Kidney Transplant Recipients

Decrease in bone mass is common in the first 6 to 12 months after kidney transplantation.

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PAIN MANAGEMENT

Multimodal Analgesia and Education Reduces Postoperative Arthroplasty Pain, Opioid Consumption

The provision of multimodal nonopioid analgesia was linked to reduced subacute pain after total knee and hip arthroplasty.

Ketamine Infusions Improve Symptoms of Depression and Pain

Patients with treatment-resistant major depressive disorder or bipolar disorder without psychotic symptoms received intravenous infusions of 0.5 mg/kg ketamine 3 times per week for 2 weeks.

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PRACTICE MANAGEMENT

Antibiotic Overprescription High Among Minority Groups and Older Patients

Approximately 64% of antibiotics prescribed for Black patients and 58% for Hispanic/LatinX patients were deemed inappropriate by the study authors.

State Laws on Adolescent Privacy Do Not Reflect Pediatric Standards of Care

Many state laws on consent and privacy for adolescents do not reflect pediatric professional standards of care.

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PSORIATIC ARTHRITIS

Risk for Severe COVID-19 Low in Patients With Psoriatic Disease

Researchers reported on the severity of COVID-19 outcomes in patients with psoriatic disease, using data from the WARCOV study.

Treatment Persistence With IL-17 vs TNF Inhibitors in Psoriasis and Psoriatic Arthritis

The long-term persistence of various biologic agents in treating psoriasis and psoriatic arthritis are investigated.

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RHEUMATOID ARTHRITIS

Improvement of RA With ABBV-599 Attributed to JAK Inhibitor

Researchers investigated whether ABBV-599 could increase the treatment response for patients with RA compared with JAK inhibitor or BTK inhibitor alone.

Infectious Risk Similar Between cDMARDs and TNFis With Concomitant Methotrexate for RA

Researchers investigated the risk for infection between leflunomide vs TNFi and tacrolimus vs TFNi among patients with rheumatoid arthritis treated with concomitant methotrexate.

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SPONDYLOARTHRITIS

Increased Intestinal Permeability Among Patients With Spondyloarthritis; Data on Rheumatoid Arthritis Inconclusive

Researchers assessed data on intestinal permeability in patients with spondyloarthritis and rheumatoid arthritis and the effects of nonsteroidal anti-inflammatory drugs on intestinal permeability.

Higher BMI Linked to Increased Risk of Developing Psoriasis

Higher body mass index (BMI) seems to be associated with an increased risk for developing psoriasis.

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SYSTEMIC LUPUS ERYTHEMATOSUS

Arterial Health Predicts Cardiovascular Disease Risk in Patients With SLE

Researchers studied the relationship between the total burden of arterial plaque and cardiovascular disease risk in patients with systemic lupus erythematosus.