Topics

TOPICS

ANKYLOSING SPONDYLITIS

Metagenomic Sequencing Reconfirms Key Role of Gut Microbiome in AS Pathogenesis

Researchers evaluated the microbial characteristics driving ankylosing spondylitis pathogenesis, and they examined the effects of tumor necrosis factor inhibitor therapy on the microbiome.

Chronic Kidney Disease More Common Among Men vs Women With Ankylosing Spondylitis

Researchers assessed and compared the risk for chronic kidney disease in men and women with ankylosing spondylitis in China.

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FIBROMYALGIA

Fibromyalgia Associated With Hypersensitivity to Heat and Auditory Stimuli

The researchers’ hypothesis is that supraspinal augmentation of sensory input, including sound, may represent a hallmark of fibromyalgia.

Higher Rates of Chronic Pain and Mood Disorders in Patients With Fibromylagia

Recently updated diagnostic criteria for fibromyalgia that reduce the underdiagnosis in men had not been implemented during these studies.

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GOUT

Urate Transporter Variants Associated With Transition From Asymptomatic Hyperuricemia to Gout

Researchers examined the genetic variants associated with the transition from hyperuricemia to gout.

Proinflammatory Cytokines Elevated in Patients With Intercritical Gout, and Linked to MSU Deposition Size and CV Risk Factors

Researchers studied subclinical inflammation in intercritical gout and its association with the size of monosodium urate crystal deposition and cardiovascular risk factors.

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LYME DISEASE

Lyme Meningitis Can Occur in Regions Where Ticks Are Uncommon

Case study shows a patient with headache and neuro-ophthalmic signs, but no rash or joint pain, had contracted Lyme meningitis.

New Guidelines for the Management of Lyme Disease

The Infectious Diseases Society of America, American Academy of Neurology, and American College of Rheumatology provided new clinical practice guidelines for Lyme disease prevention, diagnosis, and treatment.

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CONNECTIVE TISSUE DISEASE

Case Report: Stickler Syndrome Presents With Rare Ophthalmologic Manifestations

When systemic signs are not evident, ophthalmologists play a major role in diagnosis.

Anticoagulation Improves Outcomes in Idiopathic PAH, Not CTD-PAH

Systemic anticoagulation was found to improve quality-adjusted life years among patients with idiopathic pulmonary arterial hypertension but not among those with connective tissue disease-associated pulmonary arterial hypertension.

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OSTEOARTHRITIS

Warfarin vs Direct Oral Anticoagulants Associated With Higher Risk for Knee and Hip Replacements

Researchers assessed the use of warfarin vs direct oral anticoagulants in risk for knee and hip replacements, as a reflection of end-stage osteoarthritis.

Anti-Nerve Growth Factor Antibodies Reduce OA Pain, But Associated With Long-Term Adverse Events

Researchers aimed to synthesize the currently available literature on anti-NGF antibodies in OA pain and further determine whether these antibodies are associated with more change in scores for pain and physical function, patient global assessment scores, and AE incidence.

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OSTEOPOROSIS

Bone Turnover Lower Among Men With Type 2 Diabetes Mellitus, A1c Greater Than 7%

Study authors identified whether the hemoglobin A1c threshold level where reduction in bone turnover begins.

Researchers Develop Novel Diagnostic Model for Osteoporosis Based on Key Genes

By conducting machine learning analysis of gene expression profile, researchers developed a novel diagnostic signature for osteoporosis.

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PAIN MANAGEMENT

Supply Steady for Existing Patients Receiving Opioids During COVID-19

Existing patients receiving opioid analgesics and buprenorphine for opioid use disorder have continued to receive medications during the COVID-19 pandemic.

Study Identifies Sex Differences in Functional Organization of the Brain in Chronic Pain

The main goal of this study was to characterize sex differences and abnormalities in the functional segregation and integration of the whole-brain network architecture associated with chronic pain.

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PRACTICE MANAGEMENT

Strategies for Managing Uncertainty in Patient Care

For many health care professionals, successfully managing uncertainty means recognizing that surety is complicated and illusory and knowledge is iterative and provisional rather than definitive.

More Medical Errors Reported for Nurses With Poor Physical, Mental Health

Nurses with poor physical and mental health report significantly more medical errors.

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PSORIATIC ARTHRITIS

Similar Rates of Depression and Anxiety Plus Depression With Apremilast vs Other Drugs in Psoriatic Arthritis

Apremilast used for the treatment of psoriasis or psoriatic arthritis is not associated with a high risk of incident treated depression, anxiety, or anxiety plus depression.

Case Highlights Novel Approach to Treatment of Ulcerative Colitis, Psoriatic Arthritis

A recently published report presented at the 2019 AIBD Annual Meeting in Orlando, FL, discussed the case of a patient who developed ulcerative colitis (UC) following treatment with Secukinumab for her psoriatic arthritis and highlighted a novel approach for the management of both of her conditions simultaneously.

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RHEUMATOID ARTHRITIS

Early-Life Exposure to Famine Linked to Increased Risk for RA

Individuals exposed to famine in utero or in early childhood have an increased likelihood of developing rheumatoid arthritis (RA) in adulthood.

What Rheumatologists Need to Know About Cancer Risk in Rheumatoid Arthritis

An overview for rheumatologists on the management of cancer risk in patients with rheumatoid arthritis.

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SPONDYLOARTHRITIS

Improvement in Nail and Axial Symptoms With Secukinumab in Patients With Psoriatic Arthritis

The investigators reported efficacy results from the MAXIMISE trial, the first randomized controlled trial evaluating the efficacy of a biologic agent in the treatment of axial manifestations in PsA.