This study investigated the effect of TNF inhibitors on serum uric acid levels in patients with systemic autoimmune rheumatic diseases, including rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, and juvenile idiopathic arthritis.
This systematic review identified several risk factors for the development of gout, with the degree of risk between the sexes predominantly being consistent.
Considerable evidence links osteoarthritis and gout (the most common type of inflammatory arthritis), and both these conditions are commonly observed in the same patient. Gout is characterized by a high level of uric acid in the blood, or hyperuricemia, which has a distinct role in the pathogenesis of gout. With disease-modifying agents available to treat…
Analysis indicated that patients with chronic refractory gout, not achieving a protocol-defined biochemical response, might still have significant clinical benefits with pegloticase treatment.
Although prior research indicates that gout increases risk for death because of cardiovascular complications, these data highlight elevated mortality from noncardiovascular causes.
Gout was associated with increased risk for readmission for either a cardiovascular event or heart failure, and was associated with longer hospital stays in patients with acute coronary syndrome.
