HealthDay News – Progress has been made toward developing lab-grown cartilage that could postpone or possibly eliminate the need for hip replacement surgery in younger arthritis patients, according to research published online July 18 in the Proceedings of the National Academy of Sciences.
“We have an implant that can functionally replace the diseased tissue, while also fighting off inflammation that could potentially destroy the new tissue,” lead researcher Bradley Estes, PhD, vice president of research and development at Cytex Therapeutics, the Durham, N.C.-based company developing the cartilage, told HealthDay.
“The goal of this study was to use adult stem cells to engineer anatomically shaped, functional cartilage constructs capable of tunable and inducible expression of antiinflammatory molecules, specifically IL-1 receptor antagonist (IL-1Ra),” he continued.
In the new study, the researchers reported on laboratory tests of an artificial cartilage designed to replace the surface of the hip joint. The researchers used three-dimensional textile technology to create the cartilage. It “mimics natural cartilage,” Estes said, and includes a mix of plastic material and a patient’s stem cells that are supposed to produce cartilage. The cells, he said, are also programmed to reduce inflammation.
According to the study, the artificial cartilage shows signs that it can replace cartilage that has deteriorated. The plan is to create cartilage that could last 10 to 15 years and be used on joints other than the hip, Estes said.
Moutos FT, Glass KA, Compton SA, et al. Anatomically shaped tissue-engineered cartilage with tunable and inducible anticytokine delivery for biological joint resurfacing. Proc Natl Acad Sci USA. 2016 Jun 10. doi: 10.1073/pnas.1601639113 [Epub ahead of print]