Bone and Basal Metabolism Linked to Vitamin D Levels

Vitamin D Overview
Vitamin D Overview
For postmenopausal women with type 2 diabetes mellitus, the correlation between bone and basal metabolism depends on serum 25-hyroxyvitamin D levels.

HealthDay News — For postmenopausal women with type 2 diabetes mellitus (T2DMPW), the correlation between bone metabolism and basal metabolism seems to be dependent on serum 25-hydroxyvitamin D (25[OH]D) levels, according to a study published in the Journal of Diabetes Investigation.

Makiko Ogata, from the Tokyo Women’s Medical University School of Medicine, and colleagues enrolled 44 T2DMPW in a prospective follow-up study performed with vitamin D supplementation. Twenty-three patients with low 25(OH)D levels were told to increase vitamin D levels by lifestyle change. Alfacalcidol was administered to 15 patients with osteoporosis.

The researchers found that serum 25(OH)D increased and decreased in 25 and 19 patients, respectively. A decrease in 25(OH)D was seen for patients who did not receive the study intervention at the start. There was a positive correlation between changes in resting energy expenditure and those of procollagen type 1 N-terminal propeptide (P1NP)/carboxy-terminal collagen crosslinks-1. 

There was a correlation for changes in respiratory quotient with mean glycated hemoglobin levels; after the intervention P1NP correlated positively with serum 25(OH)D. The correlations were prominent in those with increased 25(OH)D and alfacalcidol supplementation.

“Restoration of vitamin D level may be a prerequisite for a normal correlation between bone and basal metabolism in T2DMPW,” the researchers wrote.

Several authors disclosed financial ties to the pharmaceutical industry.

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Ogata M, Iwasaki N, Ide R, et al. Role of vitamin D in energy and bone metabolism in postmenopausal women with type 2 diabetes mellitus: a 6-month follow-up evaluation [published online March 31, 2017]. J Diabetes Investig. doi:10.1111/jdi.12666

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