HealthDay News – Objectively-measured parental hip fracture (HF) was found to be independently associated with increased risk of major osteoporotic fracture (MOF) in offspring, according to a large population-based cohort study published in the Journal of Bone and Mineral Research.

Shuman Yang, PhD, from the University of Manitoba in Winnipeg, Canada, and colleagues used a population-based historical cohort study of 261,705 offspring (age ≤40 years) with at least one linked parent  (478,792 parents) to examine the correlation of objectively verified HF with offspring MOF and HF.

The researchers identified 7,323 incident MOF during 2.9 million person-years of offspring follow-up (4.4% vs 2.7% for those with and without a parental HF, respectively; P < .001), including 331 HF (0.3% vs 0.1%,  respectively; P < .001). There was an independent association for parental HF with increased risk of MOF (hazard ratio, 1.30; 95 percent confidence interval, 1.20 to 1.41). 


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There was a decrease in the strength of the association with older parental age at HF (Ptrend < .001); the association was no longer significant for parental HF after age 80 years (adjusted hazard ratio, 1.07; 95 percent confidence interval, 0.96 to 1.19). An even stronger correlation was seen for parental HF and offspring HF (adjusted hazard ratio, 1.64; 95 percent confidence interval, 1.21 to 2.23).

Summary and Clinical Applicability

This population-based linkage analysis found that objectively-verified parental hip fracture was an independent riskfactor for both HF and MOF.

Limitations and Disclosures

“Although the relationship between parental HF is suggested to be a [bone mineral density (BMD)] independent risk factor for offspring fracture, other skeletal factors not captured by BMD could potentially mediate the relationship,” the authors stated.

Two authors disclosed financial ties to Amgen, Eli Lily, Novartis, Genzyme, and Merck.

Reference

Yang S, Leslie WD, Yan L, et al. Objectively Verified Parental Hip Fracture Is an Independent Risk Factor for Fracture: A Linkage Analysis of 478,792 Parents and 261,705 Offspring. J Bone Miner Res. 2016; DOI 10.1002/jbmr.2849