HealthDay News — Patients with severe psoriasis and those with mild psoriasis and concomitant psoriatic arthritis have an increased risk of uveitis, according to a study published in JAMA Ophthalmology.

Ching-Chi Chi, MD, from Chang Gung Memorial Hospitals in New Taipei, Taiwan, and colleagues used a national database to evaluate risk of incident uveitis among 147,954 individuals with psoriasis and 147,954 controls without psoriasis.

The researchers found that patients with severe psoriasis with concomitant psoriatic arthritis had the greatest risk of incident uveitis versus controls (adjusted hazard ratio [aHR], 2.40; 95% confidence interval [CI], 1.90 to 3.02).

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There was also an increased risk of incident uveitis in the group with severe psoriasis without psoriatic arthritis and the group with mild psoriasis with psoriatic arthritis (aHRs, 1.42 [95% CI, 1.23 to 1.64] and 1.42 [95% CI, 1.03 to 1.96], respectively). However, there was no increased risk for incident uveitis with mild psoriasis without psoriatic arthritis (aHR, 1.09; 95% CI, 1.00 to 1.20).

“Clinicians may use this finding as a guide for uveitis risk stratification among patients with different inflammatory presentations on the spectrum of psoriatic disease,” the researchers wrote.

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Chi C, Tung T, Wang J, et al. Risk of uveitis among people with psoriasis: a nationwide cohort study [published online April 13, 2017]. JAMA. doi: 10.1001/jamaophthalmol.2017.0569

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