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RHEUMATOID ARTHRITIS

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Role of Vitamin D in Rheumatoid Arthritis Pathogenesis

Increasing evidence indicates serum vitamin D levels and polymorphisms in enzymes involved in vitamin D metabolism can affect the risk of developing rheumatoid arthritis, influence disease activity and recurrence, and increase the risk of comorbidities, such as cardiovascular diseases
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Mitigating Risk of Cardiovascular Disease in Rheumatoid Arthritis

Patients with rheumatoid arthritis have an increased risk of developing cardiovascular disease (CVD) and CVD-related mortality compared with the general population. Despite the growing recognition of CVD as a common complication of RA, many rheumatologists do not aggressively manage CV risk in patients with rheumatic disease.
Patient-Reported Outcomes (PROs) are symptoms patients with rheumatoid arthritis (RA) observe during the natural history of their disease. They provide clinicians with the patient’s perspective on her wellbeing. There is consensus on the importance of patient-reported pain, physical function, and global assessment of disease activity in assessing patients for treatment response.3 Many experts also consider fatigue and the duration of morning stiffness to be important PROs, but more data are needed to correlate these measures with outcomes. Other PROs with potential significance in assessing outcomes include flare, work participation or productivity, sleep quality, emotional distress, and coping.2,3 The use of PROs to assess disease activity allows patients with RA to take an active role in their treatment and contribute to RA research. Several challenges exist when incorporating PROs into practice, including variability in which PROs an instrument assesses and the heterogeneous nature of RA. Photo Credit: Dr P. Marazzi/Science Source

Examining Patient-Reported Outcomes in Rheumatoid Arthritis

Validation of a patient-report outcome instrument as an effective independent tool for measuring disease activity and treatment response may one day allow decreased reliance on expensive or time-consuming assessments, such as magnetic resonance imaging or joint counts.

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