Roy Fleischmann, MD, clinical professor of medicine at the University of Texas Southwestern Medical Center, discusses with Rheumatology Advisor results from the EXXELERATE trial (Study to Assess the Short- and Long-term Efficacy of Certolizumab Pegol Plus Methotrexate Compared to Adalimumab Plus Methotrexate in Subjects With Moderate to Severe Rheumatoid Arthritis Inadequately Responding to Methotrexate; Identifier: NCT01500278).

Data from this trial suggest that immediately switching from one tumor necrosis factor (TNF) inhibitor to another inhibitor was safe in those who had primary TNFi failure, even without a drug washout period.

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Fleischmann R, Burmester GR, Combe B, et al. Efficacy and safety of switching between certolizumab pegol and adalimumab after primary anti-TNF treatment failure: 2-Year results from a randomized, investigator-blind, superiority head-to-head study [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). Accessed November 28, 2016.

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