Rheumatoid Arthritis Diagnosed in Hands of 33-Year-Old Transplant Patient

HealthDay News — In a case report published online June 27 in the Annals of Internal Medicine, rheumatoid arthritis is diagnosed in the hands of a patient who underwent bilateral hand transplantation.

Brittany L Adler, MD, from the Johns Hopkins University School of Medicine in Baltimore, and colleagues present the case of rheumatoid arthritis in a woman who received allogeneic bilateral hand and forearm transplants at age 33 years. No personal or family history of rheumatoid arthritis was reported for the donor or recipient.

The authors note that the patient developed subacute bilateral hand pain and swelling 1 year after transplantation, but the patient’s elbows, shoulders, and knees were not affected. 

The graft continued to function normally. Blood test results were negative for rheumatoid factor, anti-cyclic citrullinated peptide antibodies, and antinuclear antigen, while the level of C-reactive protein was elevated to 6.5 mg/dL. Palpable bilateral synovitis in the metacarpophalangeal, proximal interphalangeal, and wrist joints was confirmed in ultrasonography and magnetic resonance imaging, with evidence of synovitis and effusions, moderate tenosynovitis, and erosive changes. Methotrexate and prednisone were added to the maintenance tacrolimus therapy. 3 years later, the patient developed new swan-neck deformities with radiographic erosions, despite ongoing immunosuppression.

“To our knowledge, this is the first report of rheumatoid arthritis in a hand transplant recipient,” the authors write. “Whether it constitutes an atypical transplant rejection is unclear.”

Related Articles


  1. Adler BL, Albayda J, Lee WPA, et al. Erosive Rheumatoid Arthritis After Bilateral Hand Transplantation. https://www.rheumatologyadvisor.com/home/topics/osteoarthritis/knee-osteoarthritis-in-early-rheumatoid-arthritis-may-affect-disease-activity-evaluation/ [published online June 27, 2017]. Ann Intern Med. doi:10.7326/L16-0588.