Immunofluorescence and immunohistochemical microscopy for SAA is typically positive in AA amyloidosis.9 Absence of staining for lambda or kappa light chains distinguishes AA amyloidosis from AL amyloidosis.6 Amino acid sequencing and mass spectroscopy of amyloid deposits can be done to identify which precursor protein is involved in amyloid pathogenesis. Serum paraproteins are typically found in amyloid light-chain (primary) amyloidosis.11 Beta-2 microglobulin accumulation in kidney glomeruli is indicative of dialysis-related AA amyloidosis and is usually seen in patients with end-stage renal disease receiving hemodialysis.7
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