Case Study: Systemic Lupus Erythematosus With Lupus Nephritis and Thrombotic Microangiopathy
A 19-year-old woman presents with complaints of progressive shortness of breath, chest pain, and lower extremity edema over the past month.
Systemic Lupus Erythematosus
SYSTEMIC LUPUS ERYTHEMATOSUS
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Clinical Trials in Childhood-Onset Systemic Lupus Erythematosus: Next Steps and Future Directions
Access to medications for childhood-onset systemic lupus erythematosus is currently limited, partly because of a lack of high-quality evidence from clinical trials. -
The Role of Viral Infections and Vaccines in the Pathogenesis of Antiphospholipid Syndrome
Recent evidence links specific bacterial, viral infections, and vaccination to the development of APS, but these associations are not clear-cut. -
Improving Medication Adherence With Drug Monitoring in SLE
Therapeutic drug monitoring may be useful to help clinicians assess nonadherence in patients with SLE. -
Are Adverse Pregnancy Outcomes Associated With Accelerated Cardiovascular Events in SLE?
The risk factors for accelerated cardiovascular disease among young women with SLE remain unclear, with multiple studies producing conflicting results. -
Managing Cognitive Dysfunction in Systemic Lupus Erythematosus
The pathogenic pathways of SLE-related cognitive dysfunction are yet to be fully elucidated, but vasculopathy, antibody-mediated neurotoxicity, impairments in cytokine signaling, and complement abnormalities have been proposed as contributing factors. -
PAH-Associated Connective Tissue Diseases: A Case for Separating SSc, SLE
Recent evidence suggests that systemic sclerosis and SLE in pulmonary arterial hypertension should be considered separate diseases. -
Clinician Roundtable: Improving Quality of Life in Systemic Lupus Erythematosus
Quality of life measurements capture unique information about systemic lupus erythematosus that are not included in disease activity or damage evaluations. -
Addressing Racial Disparities in Systemic Lupus Erythematosus Treatment
Racial disparities have been observed in the disease course and outcomes of African Americans with SLE compared with white patients with SLE. -
Expert Insight: Using Infodemiology to Fill Knowledge Gaps in SLE
Infodemiology can estimate the health-related demands and behaviors of systemic lupus erythematosus.
LATEST NEWS
Adverse Childhood Experiences Linked to Worse Lupus Outcomes
Adverse childhood experiences (ACEs) are associated with worse patient-reported systemic lupus erythematosus (SLE) outcomes.
Factors Associated With Altered Cognitive Function in Systemic Lupus Erythematosus
Systemic lupus erythematosus-specific factors (eg, inflammation, disease damage/duration) are associated with cognitive dysfunction, as well as chronic disease factors (eg, fatigue, depression, pain, medication).
Composite Risk Score With PC4d, C3, and LAC Linked to Thrombosis in SLE
A composite thrombosis risk equation including platelet C4d, low C3, and lupus anticoagulant is strongly associated with thrombosis in systemic lupus erythematosus.
Lupus Affects Emotional and Mental Well-Being of Patients
More than 60 percent of patients with lupus report that the disease has a large effect on their emotional and mental well-being.
Bacteremia Associated With Severe Flares in Systemic Lupus Erythematosus
Bacteremia occurred mostly in patients with active SLE and was frequently associated with severe flares and corticosteroid use.
SLE Frailty Index Feasible for Measuring Adverse Outcome Susceptibility
Construction of a frailty index for patients with systemic lupus erythematosus was feasible as a valid and reliable measure of adverse outcome susceptibility.
First Treatment for Children With Systemic Lupus Erythematosus Gets FDA Approval
The Food and Drug Administration (FDA) has approved the intravenous (IV) formulation of Benlysta (belimumab; GlaxoSmithKline) for the treatment of pediatric patients ≥5 years old with active, autoantibody-positive, systemic lupus erythematosus (SLE) who are receiving standard therapy.
Case Report: Stress Fractures in Systemic Lupus Erythematosus After Long-Term Methotrexate Use
Researchers report the case of a 64-year-old woman with systemic lupus erythematosus and recurrent bilateral stress fractures of the calcaneus due to long-term methotrexate use.
Increased Risk for Herpes Simplex Virus Infection Noted in Systemic Lupus Erythematosus
Risk factors included older age, history of mucocutaneous infection, and intravenous or oral steroid therapy.
Anti-Rituximab Antibodies Predictive of Infusion-Related Reactions in SLE
Researchers investigated how the presence of antidrug antibodies relates to infusion-related reactions and the effectiveness of rituximab therapy in SLE.
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