Case Study: Systemic Lupus Erythematosus With Lupus Nephritis and Thrombotic Microangiopathy
A 19-year-old woman presents with complaints of progressive shortness of breath, chest pain, and lower extremity edema over the past month.
Systemic Lupus Erythematosus
SYSTEMIC LUPUS ERYTHEMATOSUS
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Clinical Trials in Childhood-Onset Systemic Lupus Erythematosus: Next Steps and Future Directions
Access to medications for childhood-onset systemic lupus erythematosus is currently limited, partly because of a lack of high-quality evidence from clinical trials. -
The Role of Viral Infections and Vaccines in the Pathogenesis of Antiphospholipid Syndrome
Recent evidence links specific bacterial, viral infections, and vaccination to the development of APS, but these associations are not clear-cut. -
Improving Medication Adherence With Drug Monitoring in SLE
Therapeutic drug monitoring may be useful to help clinicians assess nonadherence in patients with SLE. -
Are Adverse Pregnancy Outcomes Associated With Accelerated Cardiovascular Events in SLE?
The risk factors for accelerated cardiovascular disease among young women with SLE remain unclear, with multiple studies producing conflicting results. -
Managing Cognitive Dysfunction in Systemic Lupus Erythematosus
The pathogenic pathways of SLE-related cognitive dysfunction are yet to be fully elucidated, but vasculopathy, antibody-mediated neurotoxicity, impairments in cytokine signaling, and complement abnormalities have been proposed as contributing factors. -
PAH-Associated Connective Tissue Diseases: A Case for Separating SSc, SLE
Recent evidence suggests that systemic sclerosis and SLE in pulmonary arterial hypertension should be considered separate diseases. -
Clinician Roundtable: Improving Quality of Life in Systemic Lupus Erythematosus
Quality of life measurements capture unique information about systemic lupus erythematosus that are not included in disease activity or damage evaluations. -
Addressing Racial Disparities in Systemic Lupus Erythematosus Treatment
Racial disparities have been observed in the disease course and outcomes of African Americans with SLE compared with white patients with SLE. -
Expert Insight: Using Infodemiology to Fill Knowledge Gaps in SLE
Infodemiology can estimate the health-related demands and behaviors of systemic lupus erythematosus.
LATEST NEWS
Belimumab Demonstrates Long-Term Safety, Efficacy in Systemic Lupus Erythematosus
Belimumab was well tolerated with no new safety concerns, and efficacy was maintained through 13 years of treatment.
Predictors of Remission, Low Disease Activity State Identified in SLE
Researchers examined predictors of remission and low disease activity state in systemic lupus erythematosus.
Ethnicity May Not Contribute to Clinical Differences Between Adult-, Childhood-Onset SLE
Researchers sought to determine whether ethnic differences contribute to the differences in clinical presentation between patients with childhood-onset vs adult-onset SLE.
Comparing Sensitivities of Childhood-Onset SLE Classification: SLICC vs ACR Criteria
Researchers sought to compare the sensitivities of ACR and SLICC classification criteria in childhood-onset SLE.
Lupus Low Disease Activity State Discriminates Between Belimumab and Placebo in SLE Trials
Investigators examined the discriminant capacity of the Lupus Low Disease Activity State in a post-hoc analysis of belimumab data in systemic lupus erythematosus.
Assessing Pneumococcal Vaccine Immunogenicity in Systemic Lupus Erythematosus
Researchers conducted a post hoc analysis on antipneumococcal antibody responses in patients with SLE previously immunized with the 23-valent pneumococcal polysaccharide vaccine.
Elevated Fracture Risk Observed in SLE, Lupus Nephritis
Patients with systemic lupus erythematosus were at greater risk for fractures compared with controls.
Novel Index Developed to Measure Therapeutic Response in Childhood-Onset SLE
Researchers have developed highly accurate criteria to measure clinically relevant improvement of children and adolescents with systemic lupus erythematosus.
Predicting Treatment Success in Systemic Lupus Erythematosus-Associated PAH
Treatment success in systemic lupus erythematosus-associated pulmonary arterial hypertension, as defined by the European Society of Cardiology and the European Respiratory Society, is associated with long-term survival and supports a treat-to-target strategy.
Hepatitis A Vaccine Safe in Childhood-Onset SLE
Inactivated hepatitis A vaccine may be safe and well tolerated in childhood-onset systemic lupus erythematosus.
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