Belimumab Shows Long-Term Safety, Efficacy in Lupus Nephritis
The proportion of patients with lupus nephritis achieving renal response with belimumab increased during a 6-month extension study.
Systemic Lupus Erythematosus
SYSTEMIC LUPUS ERYTHEMATOSUS
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Impaired Hand Function and Daily Activities Significant Even Among Patients With Low Disease Activity in SLE
Researchers assessed hand function and performance in activities of daily living in patients with systemic lupus erythematosus vs healthy individuals. -
Patients With Arthritis, Lupus Demonstrate Increased Resilience to Hydroxychloroquine Retinal Toxicity
The protection persisted, even though patients in the resilient group received a significantly higher total dose. -
Voclosporin Plus MMF and Steroids Provide Superior Renal Response vs Placebo in Lupus Nephritis
Researchers aimed to evaluate the efficacy and safety of calcineurin inhibitor voclosporin for the treatment of lupus nephritis. -
From Bedside to Benchtop: A Reverse Translational Approach to Study Human Lupus Nephritis Mechanisms Using Mouse Models
For Arthritis Awareness Month, Paul Hoover, MD, and colleagues provide insight into the research conducted by their team on understanding human lupus nephritis mechanisms using mouse models. -
Review Highlights Disparities in SLE, LN Care Among Medicaid Beneficiaries
Medicaid patients with SLE or lupus nephritis have worse outcomes compared with privately insured patients, research shows. -
Increased SELENA-SLEDAI Score Correlates With Organ Damage, Death in SLE
Researchers evaluated the effect of mild to moderate systemic lupus erythematosus disease activity on the risk for organ system damage and death. -
Protein Marker May Predict ESKD Risk in Membranous Lupus Nephritis
In a study, approximately one-third of patients with lupus membranous nephritis tested positive for the proteins exostosin 1/exostosin 2. -
ST-T/T-Wave Changes Most Common ECG Abnormalities in SLE; Age, Disease Duration and Activity Are Risk Factors for Abnormalities
Researchers determined the prevalence of ECG abnormalities in patients with SLE and examined the factors associated with ECG abnormalities using machine learning. -
Vaccination Rates Low Among Patients With Lupus on Medicaid
Medicaid beneficiaries with systemic lupus erythematosus (SLE) who are not vaccinated are at risk for potentially avoidable acute care use for vaccine-preventable illnesses.
LATEST NEWS
Anifrolumab Improves Skin and Joint Disease Activity in Patients With Systemic Lupus Erythematosus
According to data from a press release, which were later presented at the EULAR 2021 Virtual Congress, “Anifrolumab was consistently associated with improvements in both skin rash and arthritis across three different disease measures…in patients with moderate to severe SLE.”
Lupus Nephritis Increases Risks for Adverse Pregnancy Outcomes
In a study, preeclampsia developed in women with LN developed 9-fold more often than women with systemic lupus erythematosus and no renal involvement.
Immunosuppressant Withdrawal Safe in Patients With Lupus Nephritis in Stable Remission
Most patients with lupus nephritis who flared after immunosuppressant discontinuation re-achieved remission after restarting immunosuppressive therapy.
Addressing Health Disparities in Lupus Care and Management
In light of Arthritis and Lupus Awareness Month 2021, Rosalind Ramsey-Goldman, MD, and Candace Feldman, MD, take us on a deep dive into the existing health disparities, including in race/ethnicity and socioeconomic status, in lupus care and management.
Predictors of Poor Renal Outcomes in Pediatric Lupus Nephritis Identified
Researchers studied the clinical features, treatment modalities, and long-term renal outcomes of pediatric patients with lupus nephritis.
Stroke in Patients With SLE Associated With Poorer Outcomes, and Higher Mortality and Recurrence Rates
Researchers evaluated the outcomes of stroke in patients with systemic lupus erythematosus.
Case Report: Recurrent Lupus Nephritis 12 Years After Kidney Transplantation
Lupus nephritis recurrences, while rare, typically happen within a few years of kidney transplantation.
Smoking-Gene Link in SLE Increases Myocardial Infarction, Lupus Nephritis Risks
Investigators stress the importance of smoking cessation in patients with systemic lupus erythematosus, particularly among those carrying particular risk alleles.
Hypertensive Disorders of Pregnancy Associated With Increased Risk for Cardiovascular Disease in Women With SLE
Researchers studied the association between maternal hypertensive disorders and risk for cardiovascular outcomes in women with systemic lupus erythematosus.
Lower Income Associated With Poorer Quality of Life in Patients With Cutaneous Lupus Erythematosus
Researchers studied the effect of income on quality of life in patients with cutaneous lupus erythematosus.
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