HealthDay News — Clinical manifestations of systemic lupus erythematosus (SLE) vary by racial and ethnic groups, according to a study published online May 22 in Arthritis Care & Research.

Ernest Maningding, M.D., M.P.H., from University of California in San Francisco, and colleagues used data from the California Lupus Surveillance Project (residents of San Francisco County from 2007 to 2009) to assess racial and ethnic differences in SLE manifestations among 724 patients.

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The researchers found that blacks, Asians/Pacific Islanders (APIs), and Hispanics had an increased prevalence of renal manifestations (prevalence ratios [PRs], 1.74, 1.68, and 1.35, respectively). Additionally, there was an increased prevalence of neurologic manifestations among blacks (PR, 1.49) and an increased prevalence of hematologic manifestations among both blacks and APIs (PRs, 1.09 and 1.07, respectively). There was a higher risk for developing lupus nephritis among blacks (hazard ratio [HR], 2.4), APIs (HR, 4.3), and Hispanics (HR, 2.3), as well as a higher risk for thrombocytopenia among these groups (HRs, 2.3, 2.3, and 2.2, respectively). A higher risk for antiphospholipid syndrome was seen among APIs (HR, 2.5) and Hispanics (HR, 2.6).

“Alleviating these racial/ethnic disparities requires a multilevel approach, and as providers we need to be more vigilant about new symptoms in these patients and ensure communication that is culturally competent and breeds trust,” Maningding said in a statement.

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