Short-Form Patient-Reported Outcomes Tool Effective in SLE

The PROMIS10 patient-reported outcome measure is a valid and reliable tool in routine systemic lupus erythematosus care.

The Patient Reported Outcomes Measurement Information System Global Health Short Form (PROMIS10) is a valid and reliable tool for measuring patient-reported outcomes in routine systemic lupus erythematosus (SLE) care, according to a study published in The Journal of Rheumatology.1

PROMIS10 is a 10-item patient-reported outcome instrument for measuring physical and mental health domains that can be used across diseases and has been implemented in orthopedic, cardiovascular, and primary care populations.2,3 However, it has not been evaluated in rheumatic diseases, including SLE.

Researchers enrolled 204 outpatients with SLE who completed the PROMIS10, as well as the Medical Outcomes Study Short Form-36 (SF-36), the LupusQoL-US, and selected PROMIS computerized adaptive tests at routine visits at an SLE Center of Excellence in New York.1

They found that the PROMIS10 physical health scores strongly correlated with physical function, pain, and social health domains in the PROMIS computerized adaptive test, the SF-36, and the LupusQoL. They also found that the PROMIS10 mental health scores strongly correlated with the PROMIS depression computerized adaptive test, the SF-36, and the LupusQoL mental health domains. However, active arthritis, comorbid fibromyalgia, and anxiety were associated with worse PROMIS10 scores, but sociodemographic factors and physician-assessed flare status were not. It took patients less than 2 minutes to complete the PROMIS10, and the test-retest reliability for the physical and mental health scores was high.

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The authors conclude that PROMIS10 can efficiently screen for impaired physical function, pain, and emotional distress in outpatients with SLE.1 , “With strong correlations to LupusQoL and SF-36 but significantly reduced responder burden, PROMIS10 is a promising tool for measuring patient-reported outcomes in routine SLE clinical care and value-based healthcare initiatives,” they stated. Future studies should be include other populations of patients with rheumatic disease, and longitudinal studies of PROMIS10 in SLE should also be conducted.

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  1. Kasturi S, Szymonifka J, Burket JC, et al. Feasibility, validity, and reliability of the 10-item patient reported outcomes measurement information system global health short form in outpatients with systemic lupus erythematosus [published online February 1, 2018]. J Rheumatol. doi:10.3899/jrheum.170590
  2. Intro to PROMIS. Health Measures. Accessed February 16, 2018.
  3. Eton DT, Beebe TJ, Hagen PT, et al. Harmonizing and consolidating the measurement of patient-reported information at health care institutions: a position statement of the Mayo Clinic. Patient Relat Outcome Meas. 2014;5:7-15.