Inflammation

Classical Disease-Modifying Antirheumatic Drugs: A Possible Treatment Option for Dementia?

Classical Disease-Modifying Antirheumatic Drugs: A Possible Treatment Option for Dementia?

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The protective effects of disease-modifying antirheumatic drugs in dementia was evaluated in a retrospective cohort study.

Clinical Outcomes With MTX Monotherapy vs TNFi-MTX Combination Therapy for Early RA

Clinical Outcomes With MTX Monotherapy vs TNFi-MTX Combination Therapy for Early RA

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A randomized study sough to evaluate whether methotrexate monotherapy can safely be started before treatment optimization with a tumor necrosis factor inhibitor in patients with early, active RA.

Chronic Inflammatory Disorders May Increase Cardiometabolic, Mortality Risks

Chronic Inflammatory Disorders May Increase Cardiometabolic, Mortality Risks

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The degree of risk for cardiometabolic events and all-cause mortality appeared to increase in participants who took nonsteroidal anti-inflammatory drugs or corticosteroid drugs.

Psoriatic Arthritis Strongly Linked With Developing Diabetes Mellitus

Psoriatic Arthritis Strongly Linked With Developing Diabetes Mellitus

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Researchers find that higher levels of disease activity predict the development of diabetes mellitus in patients with psoriatic arthritis.

Brief Exercise Sessions Can Reduce Systemic Inflammation

Brief Exercise Sessions Can Reduce Systemic Inflammation

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Small study shows 20 minutes on a treadmill can decrease immune cells tied to inflammation.

Amylase-Trypsin Inhibitors and Systemic Inflammation

Amylase-Trypsin Inhibitors and Systemic Inflammation

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Amylase-trypsin inhibitors (ATIs) found in wheat have been linked to inflammation in the lymph nodes, kidneys, spleen, and brain, and can worsen symptoms of RA, SLE, and MS.

Paradoxical Activation of TNF-Regulatory Functions by Adalimumab

Paradoxical Activation of TNF-Regulatory Functions by Adalimumab

Therapeutic anti-TNF antibodies, long thought to act primarily via blockade of proinflammatory soluble TNF, appear to also bind membrane-bound TNF supporting regulatory T-cell expansion suppressing further inflammation.

No Functional Improvement in Knee OA With Spironolactone

No Functional Improvement in Knee OA With Spironolactone

Knee osteoarthritis treatment with spironolactone did not improve symptoms, physical function, or health-related quality of life in this cohort of patients.

Phase 3 Primary Endpoint Met For New JAK Inhibitor For RA

Phase 3 Primary Endpoint Met For New JAK Inhibitor For RA

The efficacy of baricitinib, an experimental small molecule JAK kinase inhibitor, was assessed in a phase 3 trial of patients with rheumatoid arthritis who had either failed treatment with conventional and synthetic DMARDs, or who were not tolerant of DMARD treatment.

TNF Inhibitors and Risk Factors for Fungal and Mycobacterial Infections

TNF Inhibitors and Risk Factors for Fungal and Mycobacterial Infections

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The use of tumor necrosis factor (TNF) inhibitors is associated with an increased risk for a variety of serious infections because TNF-alpha plays a key role in macrophage and phagosome activation, monocyte differentiation into macrophages, and neutrophil recruitment.

Lipoprotein Changes Associated With RA Treatment Regimens

Lipoprotein Changes Associated With RA Treatment Regimens

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Decreases in RA disease activity were consistently associated with increases in levels of total cholesterol over time.

Effects of Oral Contraceptives on RA Outcomes

Effects of Oral Contraceptives on RA Outcomes

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Current or previous use of oral contraceptives appears to be associated with improvements in measures of rheumatoid arthritis disease activity when measured by self-reported scores such as RAID, PROFAD, RADAI, and FFbH, as well as DAS28.

Association of MTX and Liver Cirrhosis in Patients with Concomittant RA and HBV Infection

Association of MTX and Liver Cirrhosis in Patients with Concomittant RA and HBV Infection

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Chronic MTX therapy among RA patients with CHB was not associated with an increased risk of liver cirrhosis.

Myositis Autoantibodies Associated With Chronic Course in JIIM

Myositis Autoantibodies Associated With Chronic Course in JIIM

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Myositis autoantibodies and some early clinical features are associated with a chronic disease course in juvenile myositis.

Latent CMV Infection Induces Chronic Infection Phenotype in RA

Latent CMV Infection Induces Chronic Infection Phenotype in RA

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A latent cytomegalovirus infection causes chronic infection phenotype in CD8+ cells.

Digital X-ray: Different Periarticular Hand BMD In PsA and RA After Antirheumatic Treatment

Digital X-ray: Different Periarticular Hand BMD In PsA and RA After Antirheumatic Treatment

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Researchers have found that following antirheumatic treatment, individuals with RA demonstrated ongoing bone loss in their hands, but those with PsA maintained their periarticular BMD. This suggests that different mechanisms are involved in bone remodeling of the hand in PsA.

Exercise May Reduce Impairment in Inflammatory Myopathies

Exercise May Reduce Impairment in Inflammatory Myopathies

Five randomized controlled trials including adult patients with polymyositis and dermatomyositis (DM) and additional open studies have demonstrated reduced impairment and activity limitation as well as improved quality of life. Exercise can improve muscle aerobic capacity as shown by increased mitochondrial enzyme activity. These data suggest that intensive aerobic exercise and resistance training could reduce disease activity and inflammation and improve muscle metabolism.

Workplace Exposure to Textile Dust May Increase Risk of Rheumatoid Arthritis

Workplace Exposure to Textile Dust May Increase Risk of Rheumatoid Arthritis

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Exposure to textile dust was associated with increased risk for both ACPA-positive and ACPA-negative rheumatoid arthritis.

Pneumococcal Vaccines Induce Severe Inflammatory Reaction in Patients With CAPS

Pneumococcal Vaccines Induce Severe Inflammatory Reaction in Patients With CAPS

Severe local, inflammatory reaction triggered in those with cryopyrin-associated periodic syndromes

Mortality Rates Decrease for Individuals With RA

Mortality Rates Decrease for Individuals With RA

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Rheumatoid arthritis mortality rates have decreased since 2000 due to better treatment options.

Promising Treatment for Scleroderma-Related Interstitial Lung Disease

Promising Treatment for Scleroderma-Related Interstitial Lung Disease

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Cyclophosphamide and mycophenolate mofetil efficacious for scleroderma-related lung disease, according to trial data reported at ACR/ARHP 2015.

Tocilizumab Improved Periodontal, Rheumatologic Parameters in Patients With RA

Tocilizumab Improved Periodontal, Rheumatologic Parameters in Patients With RA

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Tocilizumab was associated with significant improvement in periodontal inflammation in patients with RA.

FUTURE Trials Lead to Novel Treatment for Psoriatic Arthritis

FUTURE Trials Lead to Novel Treatment for Psoriatic Arthritis

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Results from the FUTURE trials demonstrate significant reduction in disease burden and severity of PsA with secukinumab.

DMARDS Remain First Choice Compared to Biologic Therapies for RA

DMARDS Remain First Choice Compared to Biologic Therapies for RA

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Which agent—DMARD or biologic—or combination is best for a patient with rheumatoid arthritis?

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