Juvenile Idiopathic Arthritis
Gut Microbiota Composition Analyzed in Juvenile Idiopathic Arthritis
January 30, 2019Patients with juvenile idiopathic arthritis demonstrated evidence of dysbiosis and reduced diversity in the gut microbiome.
TNFi Discontinuation During Early Pregnancy Not Linked With Worse RA, JIA Outcomes
January 30, 2019Discontinuing TNFi therapy before 20 weeks gestation was feasible in wo\men with RA and JIA who enter pregnancy with well-controlled disease.
Biologic Therapies in JIA: International Registry Data Combined
January 18, 2019National and international pharmacovigilance registry data pertaining to the use of biologic agents in patients with juvenile idiopathic arthritis have been combined.
Low Muscle Strength, Bone Mineral Density Observed in Juvenile Idiopathic Arthritis
January 02, 2019Muscle strength and bone health were suboptimal in patients with oligo- and polyarticular juvenile idiopathic arthritis compared with controls.
Single-Dose Prefilled Autoinjector for Actemra Approved
November 26, 2018Genentech announced that the FDA has approved ACTPen autoinjector for Actemra as a new formulation for adults with moderate to severe active RA.
Higher Biologic Drug Survival in JIA With Younger Age at Treatment Initiation
November 20, 2018Rates of biologic drug survival and suspension by remission were both higher in those who initiated biologic treatment at <16 years.
Rituximab May Be Effective in Children With Treatment-Resistant Juvenile Idiopathic Arthritis
November 19, 2018Rituximab may be an effective treatment option for many patients with juvenile idiopathic arthritis who did not respond to other therapies.
Determining Risk for New-Onset Uveitis in Juvenile Idiopathic Arthritis
November 08, 2018Researchers sought to quantify the annual incidence of new-onset uveitis following JIA diagnosis and identify associated risk factors.
Psychological Flexibility Improves Resilience in Children With Juvenile Idiopathic Arthritis and Their Parents
November 08, 2018Psychological flexibility in children with juvenile idiopathic arthritis and in their parents may represent resilience factors for dealing with pain and disability associated with the condition.
Canakinumab Treatment Led to Substantial Glucocorticoid Reduction in JIA
November 06, 2018Researchers evaluated the long-term efficacy and safety of canakinumab in patients with active systemic juvenile idiopathic arthritis.
Original vs Expanded Disease Activity Scoring System in JIA Examined
October 02, 2018For a more precise assessment of disease activity and treatment effectiveness in individuals with JIA, inclusion of MCP joints should be considered in the scoring system.
Actemra SC Approved to Treat Active Systemic JIA
September 14, 2018The FDA has approved Actemra SC for the treatment of active systemic JIA alone or in combination with methotrexate in patients ≥2 years old.
Examining Gaps in Mental Health Care Among Youth With Juvenile Rheumatic Disease
August 15, 2018There is an unmet need for mental health interventions that address illness-related issues affecting youth with rheumatologic conditions.
Clinical Assessment of Juvenile Idiopathic Arthritis: Predicting Unfavorable Long-Term Outcomes
June 11, 2018Prediction models of outcomes in juvenile idiopathic arthritis have acceptable precision and require only readily available baseline variables.
Clinical Correlates of JIA Relapse After Biologic Therapy Discontinuation
May 16, 2018The investigators sought to evaluate the time patients were in remission after discontinuing biologic therapy for the treatment of JIA.
Actemra SC Approved to Treat Polyarticular Juvenile Idiopathic Arthritis
May 14, 2018The FDA has approved the subcutaneous formulation of Actemra for the treatment of active polyarticular juvenile idiopathic arthritis.
Depressive Symptoms Predict Future Pain, Disability in Adolescent JIA
May 11, 2018Baseline depressive symptoms were associated with pain and disability in adolescents with juvenile idiopathic arthritis.
Efficacy, Safety of Adalimumab vs Infliximab in JIA-Associated Uveitis
May 08, 2018Researchers evaluated the safety and efficacy of adalimumab and infliximab in the treatment of juvenile idiopathic arthritis-associated uveitis in patients treated for at least 2 years.
Treatment Targets in JIA: Comparing Definitions of Clinically Inactive Disease
April 30, 2018Investigators aimed to examine the use of treatment targets in juvenile idiopathic arthritis in terms of joint limitations, functional ability, psychosocial health, and pain levels.
Managing Uveitis in Juvenile Idiopathic Arthritis: Consensus-Based Recommendations
April 23, 2018The SHARE initiative has provided recommendations for the diagnosis and treatment of juvenile idiopathic arthritis-associated uveitis.
Clinical Features Identified in Enthesitis-Related Juvenile Idiopathic Arthritis, Juvenile Spondyloarthritis
April 20, 2018Results confirm that juvenile spondyloarthritis is characterized by its peripheral pattern at disease onset, with peripheral arthritis and enthesitis.
Genetic Risk Loci Found Within Disease Phenotypes Including SLE, JIA
April 17, 2018The Epstein-Barr virus EBNA2 protein and many coclustering human transcription factors occupied nearly half of SLE risk loci.
Ultrasound Not Predictive of Disease Flares for Inactive Juvenile Idiopathic Arthritis
April 17, 2018Abnormal ultrasound findings were common in patients with juvenile idiopathic arthritis with clinically inactive disease.
Flare Risk Examined in Juvenile Idiopathic Arthritis After Anti-TNF Therapy Discontinuation
April 11, 2018Researchers sought to determine the predictors of disease flare after anti-TNF therapy discontinuation in children with polyarticular forms of juvenile idiopathic arthritis with sustained clinically inactive disease.
Examining the Role of Neutrophils in Systemic-Onset Juvenile Idiopathic Arthritis
March 05, 2018High neutrophil counts decreased after initiation of recombinant interleukin-1 receptor agonist therapy in systemic-onset juvenile idiopathic arthritis.
TNF Inhibitor Therapy Unlikely to Affect Malignancy Risk in Children
February 26, 2018Children with juvenile idiopathic arthritis, pediatric inflammatory bowel disease, and pediatric plaque psoriasis had an increased incidence of childhood malignancies, regardless of TNFi exposure.
Juvenile Idiopathic Arthritis: Baseline Ultrasound Abnormalities May Predict Relapse
February 15, 2018Abnormality on an ultrasound examination significantly increased the risk for flare in patients with juvenile idiopathic arthritis.
Improving Pediatric Rheumatic Disease Care With Consensus-Based Treatment Plans
February 08, 2018The goal of consensus treatment plans is to drive a cycle of innovation and replacement that allows the addition of new treatments and the removal of unused or ineffective strategies.
More Severe Disease Found in Juvenile Myositis With Anti-NT5C1A Autoantibodies
February 07, 2018Autoantibodies that recognize cytosolic 5′-nucleotidase 1A were detected in about 25% of patients with juvenile myositis and juvenile idiopathic arthritis.
Choosing a Biologic Therapy for JIA: Etanercept vs Tocilizumab vs IL-1 Inhibitors
January 31, 2018Treatment response was most significant in patients taking either tocilizumab or an interleukin-1 inhibitor.
Rheumatology Advisor Articles
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- Clinical, Radiographic Benefits of Tofacitinib Sustained for 2 Years in Rheumatoid Arthritis
- Cardiovascular Safety in Gout: Interpreting Data From the CARES Trial
- Axial Disease More Common in Psoriatic Arthritis With Acute Skin Manifestations
- Vaccination Guidelines Released for Patients With Immune-Mediated Disorders
- Does Cold Weather Affect Arthritis and Joint Pain?
- BMD Improved Significantly With Denosumab vs Bisphosphonates in Osteoporosis
- JAK Inhibitor Tapering in Rheumatoid Arthritis: Implications for Patients in Sustained Remission
- Yoga May Help With Rheumatoid Arthritis Symptoms, Severity
- Mycoplasma Pneumonia Increases Risk for Rheumatoid Arthritis
- Effectiveness of Biologic DMARDs in Rheumatoid Arthritis Compared
- Subchondral Pathology Independently Associated With Knee Osteoarthritis
- Yoga May Help With Rheumatoid Arthritis Symptoms, Severity
- Effects of Monetary Bonuses on Physician Care in Chronic Disease