Juvenile Idiopathic Arthritis

Juvenile Idiopathic Arthritis: Baseline Ultrasound Abnormalities May Predict Relapse

Juvenile Idiopathic Arthritis: Baseline Ultrasound Abnormalities May Predict Relapse

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Abnormality on an ultrasound examination significantly increased the risk for flare in patients with juvenile idiopathic arthritis.

Improving Pediatric Rheumatic Disease Care With Consensus-Based Treatment Plans

Improving Pediatric Rheumatic Disease Care With Consensus-Based Treatment Plans

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The goal of consensus treatment plans is to drive a cycle of innovation and replacement that allows the addition of new treatments and the removal of unused or ineffective strategies.

More Severe Disease Found in Juvenile Myositis With Anti-NT5C1A Autoantibodies

More Severe Disease Found in Juvenile Myositis With Anti-NT5C1A Autoantibodies

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Autoantibodies that recognize cytosolic 5′-nucleotidase 1A were detected in about 25% of patients with juvenile myositis and juvenile idiopathic arthritis.

Choosing a Biologic Therapy for JIA: Etanercept vs Tocilizumab vs IL-1 Inhibitors

Choosing a Biologic Therapy for JIA: Etanercept vs Tocilizumab vs IL-1 Inhibitors

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Treatment response was most significant in patients taking either tocilizumab or an interleukin-1 inhibitor.

Adalimumab Effective in JIA-Associated Uveitis Unresponsive to Methotrexate

Adalimumab Effective in JIA-Associated Uveitis Unresponsive to Methotrexate

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Adalimumab was well tolerated and associated with persistent uveitis improvement in most cases.

Juvenile Idiopathic Arthritis Disease Activity Low but Stable During Pregnancy

Juvenile Idiopathic Arthritis Disease Activity Low but Stable During Pregnancy

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An increase in disease activity 6 weeks postpartum suggests the need for tight follow-up of women with juvenile idiopathic arthritis.

Fluorescence Optical Imaging for Diagnosis of Pediatric Rheumatologic Conditions

Fluorescence Optical Imaging for Diagnosis of Pediatric Rheumatologic Conditions

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Chronic inflammatory rheumatologic diseases benefit from early anti-inflammatory treatment; however, interdisciplinary approaches may be necessary for identifying and managing noninflammatory joint pain.

Clinical Juvenile Arthritis Disease Activity Score Use in Treat-to-Target Therapy

Clinical Juvenile Arthritis Disease Activity Score Use in Treat-to-Target Therapy

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The objective of this study is to determine whether the JADAS or cJADAS would accurately predict patients with JIA in need of treatment escalation to anti-TNF after starting MTX.

Internet Intervention Improves Pain, QoL in Juvenile Idiopathic Arthritis

Internet Intervention Improves Pain, QoL in Juvenile Idiopathic Arthritis

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Psychoeducational treatments can aid in the transition to adult care, but this is often lacking for teens due to access issues.

Pregnancy Outcomes in SLE vs Other Connective Tissue, Inflammatory Rheumatic Conditions

Pregnancy Outcomes in SLE vs Other Connective Tissue, Inflammatory Rheumatic Conditions

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Real-world data indicate that although most patients with systemic lupus erythematosus or connective tissue diseases have successful pregnancies, more adverse pregnancy outcomes occur.

Evolving Technologic Strategies for Managing Juvenile Idiopathic Arthritis

Evolving Technologic Strategies for Managing Juvenile Idiopathic Arthritis

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Technological advances may assist children and adolescents with JIA, who are both more forgetful and more resistant to therapy.

Juvenile Idiopathic Arthritis Subcutaneous Golimumab in Active Polyarticular-Course

Juvenile Idiopathic Arthritis Subcutaneous Golimumab in Active Polyarticular-Course

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Golimumab use in children with active polyarticular-course JIA resulted in rapid, clinically meaningful improvements.

Juvenile Idiopathic Arthritis Increases Risk of Postpartum Complications

Juvenile Idiopathic Arthritis Increases Risk of Postpartum Complications

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Ongoing inflammation related to JIA may put first-time mothers at risk for complications.

Guidelines for Peri-Op Care in Rheumatic Disease

Guidelines for Peri-Op Care in Rheumatic Disease

These guidelines address the use of antirheumatic drugs for adults with RA, SpA, JIA, and SLE undergoing THA or TKA.

ANG-2 as Disease Marker in Children With Juvenile Idiopathic Arthritis

ANG-2 as Disease Marker in Children With Juvenile Idiopathic Arthritis

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When combined with ultrasound examination, ANG-2 can help lead to the appropriate therapy for JIA.

Juvenile Idiopathic Arthritis Treatment With TNFIs Linked to Infection Risk

Juvenile Idiopathic Arthritis Treatment With TNFIs Linked to Infection Risk

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Clinicians should consider the risk/benefit of prescribing TNFIs to children with idiopathic arthritis.

MTX + Adalimumab Effective in JIA-Associated Uveitis

MTX + Adalimumab Effective in JIA-Associated Uveitis

In children with active juvenile idiopathic arthritis, the treatment combination controls eye inflammation.

Tocilizumab Highly Effective in Refractory Juvenile Idiopathic Arthritis-associated Uveitis

Tocilizumab Highly Effective in Refractory Juvenile Idiopathic Arthritis-associated Uveitis

Tocilizumab therapy showed rapid improvement in ocular parameters for uveitis in juvenile idiopathic arthritis patients.

The Handoff: Your Week in Rheumatology News - 2/24/17

The Handoff: Your Week in Rheumatology News - 2/24/17

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Juvenile idiopathic arthritis highlights this week's edition, plus other news in the world of rheumatic disease.

Juvenile Arthritis with Sleep Apnea Impairs Neurobehavioral Performance

Juvenile Arthritis with Sleep Apnea Impairs Neurobehavioral Performance

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Study examines children with juvenile idiopathic arthritis who underwent overnight polysomnography and neurobehavioral assessments.

EULAR/PReS Standards for Transitional Care of Juvenile-Onset Rheumatic Diseases

EULAR/PReS Standards for Transitional Care of Juvenile-Onset Rheumatic Diseases

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Panel advises that up to 50% of young patients with juvenile-onset rheumatic diseases fail to successfully transition to adult rheumatology services.

Challenges in Transitioning from Pediatric to Adult Rheumatology Care

Challenges in Transitioning from Pediatric to Adult Rheumatology Care

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The process of transition from pediatric to adult rheumatology care represents a vulnerable period. The patient, physicians, and the patient's family must collaborate in advance planning and preparation to ensure a smooth transfer of care.

ADA Dosed Weekly Safe in Pediatric JIA, Chronic Uveitis

ADA Dosed Weekly Safe in Pediatric JIA, Chronic Uveitis

Most commonly used to treat chronic uveitis, weekly adalimumab was linked to a positive clinical response in 93% of patients.

Shift Towards Prescribing Alternative Biologics for JIA

Shift Towards Prescribing Alternative Biologics for JIA

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Researchers have noted a prescribing shift towards the use of alternative biologics that they believe is mostly driven by disease subtype and history of chronic anterior uveitis.

What is Association Between Preterm Delivery and JIA Development?

What is Association Between Preterm Delivery and JIA Development?

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While no association was found between previously reported risk factors of JIA, including exposure to smoking, infection early in life, or lack of breastfeeding, an association was found between JIA and premature birth.

Abatacept Autoinjector Product Now Available for RA

Abatacept Autoinjector Product Now Available for RA

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Bristol-Myers Squibb announced the launch of Orencia (abatacept) ClickJect Autoinjector, a new autoinjector that features push button operation and step-by-step instructions to assist in the injection process.

Transthyretin Autoantibodies in Juvenile Idiopathic Arthritis

Transthyretin Autoantibodies in Juvenile Idiopathic Arthritis

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An increase in transthyretin (TTR) autoantibodies was found in the JIA population as compared with controls.

Role of Periodontitis in the Development of CCP-Positive JIA

Role of Periodontitis in the Development of CCP-Positive JIA

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This study investigated antibody responses to oral pathogens and the clinical features of periodontitis in children with CCP-positive juvenile idiopathic arthritis (JIA). The results of this study supported the hypothesis that P gingivalis may play a role in the pathogenesis of CCP-positive JIA.

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