Lupus Nephritis

Case Study: Systemic Lupus Erythematosus With Lupus Nephritis and Thrombotic Microangiopathy

Case Study: Systemic Lupus Erythematosus With Lupus Nephritis and Thrombotic Microangiopathy

A 19-year-old woman presents with complaints of progressive shortness of breath, chest pain, and lower extremity edema over the past month.

Lupus Nephritis Therapy Response Predicts Survival Odds

Lupus Nephritis Therapy Response Predicts Survival Odds

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Complete response to induction therapy is associated with significant 82% decreased odds of death at 12 months.

Kidney Transplantation Increases Survival in Lupus Nephritis Cases

Kidney Transplantation Increases Survival in Lupus Nephritis Cases

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In a nationwide study, renal transplant recipients with lupus nephritis had a 70% lower risk for all-cause mortality than nonrecipients.

Urine Immunoassay Identifies Novel Lupus Nephritis Biomarkers

Urine Immunoassay Identifies Novel Lupus Nephritis Biomarkers

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Using electrochemiluminescence, researchers found 5 urinary proteins that have "reasonable specificity" for lupus nephritis.

Similar Long-Term Outcomes in Early- vs Late-Onset Lupus Nephritis

Similar Long-Term Outcomes in Early- vs Late-Onset Lupus Nephritis

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Researchers observed comparable long-term outcomes between patients with late- and early-onset lupus nephritis.

Low-Dose Leflunomide Effective for Treatment of Proliferative Lupus Nephritis

Low-Dose Leflunomide Effective for Treatment of Proliferative Lupus Nephritis

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Data support the clinical efficacy of low-dose leflunomide combined with prednisone for the treatment of proliferative lupus nephritis.

Lupus Nephritis With Impaired Renal Function Linked to Atherosclerosis in SLE

Lupus Nephritis With Impaired Renal Function Linked to Atherosclerosis in SLE

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Lupus nephritis in combination with impaired renal function is strongly associated with the presence of atherosclerosis in patients with systemic lupus erythematosus.

Comparing Factors Associated With Tubulointerstitial Inflammation in Lupus Nephritis

Comparing Factors Associated With Tubulointerstitial Inflammation in Lupus Nephritis

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Routinely available serologic markers have no correlation with tubulointerstitial damage in patients with lupus nephritis.

Examining Trends of Histologic Presentation, Renal Outcomes in Lupus Nephritis

Examining Trends of Histologic Presentation, Renal Outcomes in Lupus Nephritis

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Investigators sought to evaluate changes in demographic, clinical, and histologic presentation in patients with lupus nephritis between 1970 and 2016.

Examining Remission Status as a Predictor of Long-Term Renal Survival in Lupus Nephritis

Examining Remission Status as a Predictor of Long-Term Renal Survival in Lupus Nephritis

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Remission status was a significant and useful predictor of renal survival, in patients with lupus nephritis.

Autoimmune Reactivity to Malondialdehyde in SLE Linked to High Disease Activity, Lupus Nephritis

Autoimmune Reactivity to Malondialdehyde in SLE Linked to High Disease Activity, Lupus Nephritis

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Researchers investigated serum IgG anti-MDA expression and associations with disease activity in patients with systemic lupus erythematosus.

Mortality, ESRD Incidence Measured in Men vs Women With Lupus Nephritis

Mortality, ESRD Incidence Measured in Men vs Women With Lupus Nephritis

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No significant differences were observed in the incidence of ESRD and mortality among men vs women with lupus nephritis.

The Handoff: Your Week in Rheumatology News - 4/14/17

The Handoff: Your Week in Rheumatology News - 4/14/17

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This week, a phase III trial for investigational drug voclosporin for lupus nephritis treatment was approved, prolonged insomnia may lead to less robust bone formation — causing osteoporosis and bone fractures — and researchers found that women who drink a moderate amount of alcohol daily have a reduced risk of developing systemic lupus erythmatosus.

SLE Patients With Lupus Nephritis Have Higher Cardiovascular Event Risk

SLE Patients With Lupus Nephritis Have Higher Cardiovascular Event Risk

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Lupus nephritis a risk factor for some, but not all, cardiovascular outcomes in study of patients with SLE.

Targeted IL-6 Inhibition With Sirukumab Ineffective in Lupus Nephritis

Targeted IL-6 Inhibition With Sirukumab Ineffective in Lupus Nephritis

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Targeted IL-6 inhibition with sirukumab did not demonstrate efficacy or acceptable safety in patients with active lupus nephritis concomitantly receiving immunosupprsant therapy.

SLE Pregnancy Outcomes Impacted by Maternal Race, Ethnicity

SLE Pregnancy Outcomes Impacted by Maternal Race, Ethnicity

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Researchers found significant disparities in pregnancy complications rates and hospitalization costs among white, black, and Hispanic women with systemic lupus erythematosus

Improving Sensitivity of LN Urinary Markers by Combining Panels

Improving Sensitivity of LN Urinary Markers by Combining Panels

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Panels of urinary biomarkers were shown to be have increased diagnostic power in predicting complete clinical responses when compared with individual biomarkers.

SLE Renal Outcomes With Mixed LN and Pure Proliferative LN Compared

SLE Renal Outcomes With Mixed LN and Pure Proliferative LN Compared

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The association between mixed proliferative lupus nephritis (MPLN), pure proliferative lupus nephritis (PPLN), and short-term renal outcomes was examined in new research.

Anti-Smith Antibodies Indicative of Poor Prognosis in Biopsy-Proven LN

Anti-Smith Antibodies Indicative of Poor Prognosis in Biopsy-Proven LN

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The predictive value for future need for immunosuppression of anti-smith antibodies found on biopsy-proven lupus nephritis was evaluated in a retrospective analysis

Prognostic Significance of Renal Crescents in Lupus Nephritis

Prognostic Significance of Renal Crescents in Lupus Nephritis

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In lupus nephritis, a higher proportion of crescents found on kidney biopsy increased the risk for unfavorable outcomes.

Allograft Survival After Renal Transplantation for Lupus Nephritis

Allograft Survival After Renal Transplantation for Lupus Nephritis

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Transplantation is a suitable option for some patients with end-stage renal disease associated with lupus nephritis after careful consideration of several factors.

Renal Biopsy: Impact on Diagnosis, Prognosis, and Clinical Decision Making in Lupus Nephritis

Renal Biopsy: Impact on Diagnosis, Prognosis, and Clinical Decision Making in Lupus Nephritis

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Although renal biopsy is relatively safe and serious complications are uncommon, the risk of bleeding and other adverse events remains a key concern.

IL-6, IL-17 Accurate Biomarkers for Systemic Lupus Erythematosus Disease Activity

IL-6, IL-17 Accurate Biomarkers for Systemic Lupus Erythematosus Disease Activity

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Systemic lupus erythematosus disease activity can be assessed using IL-6 and IL-17 baseline serum levels as biomarkers.

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