Osteoarthritis News Archive
Investigators examined the effect of an interdisciplinary, combined intervention in patients with hand osteoarthritis.
Patellar mobilization therapy plus exercise has the potential to reduce pain and improve function and quality of life for patients with knee OA.
Higher fibrosis scores were associated with lower radiographic disease severity over time in patients with knee osteoarthritis.
The FDA has granted Fast Track designation for GLPG1972/S201086 for the treatment of osteoarthritis.
Four pain susceptibility phenotypes were identified in patients who had or were at risk for knee osteoarthritis, as well as risk factors for the development of persistent knee pain.
Researchers examined the effect of physical activity on cartilage thickness loss in knee osteoarthritis.
Researchers compared patient-physician discordance in global assessment in patients with osteoarthritis vs patients with rheumatoid arthritis seen in routine care.
Data show that low-dose radiation therapy does not lead to a substantial reduction in symptoms in patients with knee OA compared with sham therapy.
About 1 in 3 adults with prediabetes has arthritis, and half of those with both conditions are physically inactive and/or obese.
Exercise therapy does not increase the concentration of molecular biomarkers related to cartilage turnover and inflammation.
Researchers developed two models to estimate an individual's risk for primary THR and TKR.
Childhood maltreatment was associated with adulthood arthritis, particularly among those who experienced severe or frequent abuse.
Researchers evaluated measurement properties of self-report physical activity instruments for patients with osteoarthritis.
Researchers examined the longitudinal relationship between bone mineral density and the incidence and progression of knee, hip, and hand osteoarthritis.
The use of gentamicin-impregnated beads and/or sponges should be discouraged in early acute periprosthetic joint infection as their use is associated with high failure rates.
Among patients undergoing TKA, aspirin alone may provide protection against postoperative VTE that is similar to that of other anticoagulants.
The presence of 3 common rheumatoid arthritis-associated antibodies were not associated with erosive disease in patients with hand osteoarthritis.
For individuals with knee OA, replacing time not walking with walking at moderate-to-vigorous intensity is associated with reduced risk for TKA over 5 years.
A population-based, cohort study was conducted to identify knee pain in a group of older adults.
Investigators sought to determine if change in knee effusion volume from baseline to 1 year was predictive of cartilage volume loss and osteoarthritis progression in individuals at risk for osteoarthritis of the knee.
Following elective arthroscopic hip surgery, the rate of 7 major clinical comorbidities increases significantly.
Intra-articular injection of triamcinolone acetonide extended-release may be an effective corticosteroid treatment in patients with knee osteoarthritis and comorbid type 2 diabetes.
Pain Severity May Partly Mediate the Association Between Depression and Physical Performance in Knee OA
Pain may partly mediate the observed association between physical performance and depressive symptoms in patients with radiographic knee osteoarthritis.
Researchers assessed quadriceps strength and physical function in individuals with knee osteoarthritis.
Replacing at least 10 minutes a day of time spent sedentary, asleep, or in light physical activity with moderate physical activity may be associated with significant reductions in bodily pain interference and knee pain in adults at risk for osteoarthritis knee pain.
Individuals using statins over 5 years and those using atorvastatin reported a lower risk for future osteoarthritis-related knee pain.
Hyaluronic acid therapy may be more effective when supplemented with intra-articular platelet-rich plasma injections vs alone in treating primary knee osteoarthritis.
Persistence of extensive effusion-synovitis over time was associated with the greatest risk for cartilage damage progression.
The combined effects of pain with insomnia and pain with depression increased diverse types of health care use.
Treatment strategies for late acute prosthetic joint infections should be individualized according to patients' age, comorbidities, clinical presentation, and microorganism causing the infection.
A decrease of pain and a decrease of dynamic knee instability mediated the effect of wearing a soft knee brace on reduction of activity limitations.
Researchers examined the correlation between knee pain and radiographic features of osteoarthritis.
EULAR has released updated guidelines for the management of hand osteoarthritis.
Bilateral hip or knee osteoarthritis was significantly associated with a 16% to 25% increased risk for incident diabetes.
Buckling of the hip joint, also referred to as "giving way," and hip injuries may be associated with hip pain worsening in patients with symptomatic hip osteoarthritis.
The main risk factors leading to knee replacement surgery in patients with osteoarthritis include disease severity, symptoms, and high BMI.
Change in pain and physical function score from baseline were chosen as the co-primary endpoints.
The reliability of retrospective and daily pain measurements was comparable among patients with hip osteoarthritis, except in individuals with severe intermittent pain for whom retrospective measurements may be less reliable.
The use of accelerometry data has led to the discovery of performance phenotypes of lumbar spinal stenosis and osteoarthritis.
Use of cross-linked polyethylene has significantly reduced the revision rate following total hip arthroplasty for osteoarthritis.
Researchers examine the association between the knee adduction moment and increased knee pain during walking in patients with knee osteoarthritis.
Researchers examine the relationship of joint hypermobility with osteoarthritis and symptoms at the foot or ankle.
Higher PainDETECT Scores, Neuropathic Pain Preoperatively May Increase Risk for Chronic Pain Post-TKR
Individuals with knee osteoarthritis who have indicators of high vs low/no levels of neuropathic pain may be at elevated risk for chronic pain after total knee replacement surgery.
Six-minute walking distance was significantly associated with arterial stiffness in individuals with osteoarthritis.
Pfizer and Lilly announced positive results from a study evaluating tanezumab, an investigational humanized monoclonal antibody, for the treatment of OA pain.
Diagnostic prediction modeling for knee osteoarthritis in adolescent men helps calculate the individual and population risk of developing knee osteoarthritis over 40 years.
Neuropathic-like symptoms may affect pain-related quality of life ratings and function in patients with hip and knee osteoarthritis, respectively.
Women with osteoarthritis who reported lower physical activity levels before total joint replacement were more likely to experience mobility limitations in late life.
Researchers observed no association between statin initiation and incident hand osteoarthritis.
Changes in the 20-meter walking test were associated with worsening in bone marrow lesions and effusion volume in adults who developed accelerated knee OA.
Preterm birth and low birth weight have been linked to hip bone shape abnormalities and hip osteoarthritis.
For overweight and obese older adults with knee osteoarthritis, greater weight loss is associated with superior clinical and mechanistic outcomes.
Researchers sought to determine whether central or peripheral adiposity measures are associated with incident radiographic knee osteoarthritis independent of BMI.
Investigators sought to determine whether female reproductive and hormonal factors affect the incidence of total knee arthroplasty for osteoarthritis.
The Reliable Change Index may be an effective method for identifying changes in joint space width in clinical and research settings.
PJI is a challenging complication of joint arthroplasty with few effective treatment options.
Consensi combines amlodipine besylate, a calcium-channel blocker, and celecoxib, a nonsteroidal anti-inflammatory drug.
Investigators sought to evaluate intra-articular onabotulinumtoxinA 400 U and 200 U in reducing symptoms of knee OA in patients with nociceptive pain.
Researchers sought to investigate the cross-sectional association between patient-reported swelling and effusion-synovitis on MRI in patients with OA and meniscal tear.
Baseline obesity is associated with an increased risk for late-life mobility limitations in women undergoing joint replacement for OA.
Risedronate could significantly reduce periprosthetic bone resorption in patients undergoing total hip arthroplasty.
In 2014, healthcare provider counseling for weight loss for adults with arthritis and overweight or obesity was 45.5%, which increased from 10.4% in 2002.
Interim data have been released from a phase 3b, open-label study that evaluated the safety and tolerability of repeat administration of Zilretta in patients with knee osteoarthritis.
Men, non-Hispanic blacks, and participants with low income or obesity had the most pronounced decrease in RA prevalence.
Researchers sought to determine the predictive value of tibiofemoral MRI, patellofemoral MRI, and KLG1 for the incidence of clinical or radiographic knee OA.
In patients with painful hip osteoarthritis, an intramuscular glucocorticoid injection may effectively alleviate hip pain in the short-term.
Intravenous and subcutaneous administration of tanezumab may provide similar analgesia and tolerability in patients with hip or knee osteoarthritis.
Laparoscopic gastric band surgery is associated with more improvement in knee osteoarthritis in younger patients and in patients without prior knee injury.
Intraocular pressure was increased in patients who underwent a triamcinolone steroid knee injection, but not in patients who received a hyaluronic acid knee injection.
Patients aged 45 to 64 had an increase in the total hip arthroplasty revision rate from 2007 to 2013.
Researchers sought to identify associations of female reproductive factors with incidence of total knee arthroplasty in osteoarthritis.
Opioids and nonopioid analgesics were found to provide similar improvements in pain-related function in patients with chronic back pain or knee or hip OA pain.
Reduction in pain and disability for knee OA is linked with minimally invasive, image-guided geniculate artery embolization.
Investigators sought to identify determinants associated with improved response to intra-articular hyaluronic acid treatment in individuals with knee OA.
The effects of glucosamine supplements were not superior to the effects of ibuprofen in the treatment of patients with temporomandibular joint OA.
Researchers sought to investigate the effectiveness of colchicine on pain and function in symptomatic knee osteoarthritis.
Stem cell therapy for knee osteoarthritis is expanding, with costs exceeding $5000 for each therapy.
Low pressure pain thresholds at baseline predicted worse pain outcomes after total knee replacement surgery, but did not predict outcomes after nonsurgical interventions.
The dose-response effects of physical therapy and tai chi for patients with knee OA are approximately linear.
More than half of patients with no or mild radiographic knee osteoarthritis prior to knee replacement surgery progressed to severe osteoarthritis over 4 years of follow-up.
Results from the EPCAT II trial show that aspirin was not significantly different from rivaroxaban for the prevention of deep vein thrombosis or pulmonary embolism after total hip or knee arthroplasty.
Researcher sought to determine the effectiveness of hydroxychloroquine vs placebo as an analgesic treatment of hand osteoarthritis.
The effects of combination COX-2 inhibitor therapy with metformin on joint replacement rates were examined in patients with osteoarthritis and diabetes.
In older patients with knee OA, pain expectancy may affect the pain experience after genuine and sham electroacupuncture.
Patients with end-stage knee or hip osteoarthritis may often experience neuropathic pain, particularly at rest.
Use of the 2006 Orlando criteria vs the 2007 Budapest criteria for diagnosis of CRPS may lead to misdiagnosis of unexplained pain after TKA.
There is a need for programs that are designed to decrease disparities in joint replacement use among various populations.
Many individuals who use nonsteroidal anti-inflammatory drugs tend to exceed the daily dose limit.
The use of celecoxib in patients with OA and RA was associated with a similar or a lower risk for cardiovascular, gastrointestinal, and renal adverse events compared with ibuprofen and naproxen.
Routine rehabilitation therapy along with adjunctive acupuncture may not provide a significant benefit over exercise, after total knee replacement.
Genicular nerve block may not predict pain relief following genicular nerve cooled radiofrequency ablation in patients with chronic knee pain due to OA.
Seven studies were included in a meta-analysis examining the potential benefit of bisphosphonate therapy in knee osteoarthritis.
Insulin resistance may be experienced by patients with T2D who receive an intra-articulate corticosteroid of betamethasone injection at the knee joint.
There was an increase in the age-adjusted prevalence of reporting health care provider counseling for exercise in adults with arthritis.
Patients with rheumatic diseases have a higher risk for dementia.
The use of intra-articular hyaluronic acid injections in patients with osteoarthritis of the knee has shown efficacy in delaying total knee replacement surgery.
A study sought to determine whether physical activity has a protective effect against development of joint symptoms in middle-aged women.
Short-acting opioids are comparable with long-acting opioid medications for managing pain in patients with chronic osteoarthritis.
For patients with osteoarthritis-related knee pain, cooled radiofrequency ablation may provide greater pain relief compared with steroid injections.
Hydroxychloroquine is not significantly more effective in treating osteoarthritis of the hand than placebo.
Rheumatology Advisor Articles
- Synovial Thickening on Ultrasonography May Predict Arthritis Development
- Lutikizumab May Not Improve Outcomes in Erosive Hand Osteoarthritis
- Tender Joint Count May Not Reflect Inflammation Activity in Rheumatoid Arthritis
- Urine Immunoassay Identifies Novel Lupus Nephritis Biomarkers
- Smoking Linked to Increased Disease Activity in Rheumatoid Arthritis
- Using Telemedicine in Rheumatology: Outcomes, Costs, and Patient Satisfaction
- New Appointment Algorithm Helps Clinicians Manage Time Better
- Urine Immunoassay Identifies Novel Lupus Nephritis Biomarkers
- Ultrasound: A Sensitive Imaging Tool for Evaluating Suspected CPPD in Hip Joints
- Managing Bisphosphonate Drug Holidays in Patients With Osteoporosis
- No Clinically Meaningful Safety Differences Between Sarilumab, Tocilizumab in RA
- Biologic Therapies in JIA: International Registry Data Combined
- Risk Factors Associated With Chronic Opioid Use in Musculoskeletal Pain
- DHS, HHS Proposal Set to Upend Health Care for Non-Citizen Children
- Protecting Your Practice From Data Breaches: An Expert Interview