Osteoarthritis

Subchondral Pathology Independently Associated With Knee Osteoarthritis

Subchondral Pathology Independently Associated With Knee Osteoarthritis

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Data show that subchondral pathology was associated with symptomatic knee OA independently of chondropathy and synovitis.

Lutikizumab May Not Improve Pain, Inflammation in Knee Osteoarthritis

Lutikizumab May Not Improve Pain, Inflammation in Knee Osteoarthritis

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Lutikizumab may not improve pain or inflammation in patients with knee osteoarthritis and concomitant synovitis.

Opioid Use Varies by State Among Patients With Osteoarthritis

Opioid Use Varies by State Among Patients With Osteoarthritis

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Researchers observed substantial statewide variation in rates of treatment with long-term opioid therapy in osteoarthritis.

Heberden Nodes Linked to Structural Progression in Knee Osteoarthritis

Heberden Nodes Linked to Structural Progression in Knee Osteoarthritis

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The presence of Heberden nodes may be predictive of increased MRI-based periarticular bone area expansion.

Tanezumab Beneficial in Second Phase 3 Osteoarthritis Pain Trial

Tanezumab Beneficial in Second Phase 3 Osteoarthritis Pain Trial

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Tanezumab is a humanized monoclonal antibody that selectively targets, binds to, and inhibits nerve growth factor (NGF).

Texting Intervention Engages Patients After Joint Arthroplasty

Texting Intervention Engages Patients After Joint Arthroplasty

A text-messaging bot is effective for increasing patient engagement after primary total knee or hip arthroplasty.

Pain Catastrophizing Associated With Quality of Life in Hip Osteoarthritis

Pain Catastrophizing Associated With Quality of Life in Hip Osteoarthritis

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Pre-surgical pain catastrophizing may be independently associated with quality of life in patients with severe hip osteoarthritis.

LDL Cholesterol, BMI May Be Linked to Risk for Osteoarthritis

LDL Cholesterol, BMI May Be Linked to Risk for Osteoarthritis

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Data show a causal association between lower LDL cholesterol and increased risk for osteoarthritis.

Meniscal Damage Predicts Development of Accelerated Knee Osteoarthritis

Meniscal Damage Predicts Development of Accelerated Knee Osteoarthritis

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Investigators suggest a possible link between accelerated knee osteoarthritis and destabilizing meniscal tears in ≥2 areas along with other pathologies.

Radiographic Knee Osteoarthritis Tied to Increased Mortality Risk

Radiographic Knee Osteoarthritis Tied to Increased Mortality Risk

Radiographic knee osteoarthritis is associated with an increased risk for mortality from cardiovascular disease, diabetes, and renal diseases, but self-reported OA is not.

TriVisc Now Available in the US to Treat Osteoarthritis Knee Pain

TriVisc Now Available in the US to Treat Osteoarthritis Knee Pain

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TriVisc contains highly purified hyaluronic acid that helps supplement the viscous properties of the fluid in the knee joint.

Hormone Therapy Linked to Reduced Symptomatic Knee OA in Postmenopausal Women

Hormone Therapy Linked to Reduced Symptomatic Knee OA in Postmenopausal Women

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Hormone therapy in postmenopausal women may be protective against knee OA.

Lutikizumab May Not Improve Outcomes in Erosive Hand Osteoarthritis

Lutikizumab May Not Improve Outcomes in Erosive Hand Osteoarthritis

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Treatment with lutikizumab did not result in significantly better improvements in hand joint pain.

Longitudinal Reliability Validated for OMERACT Thumb Base Osteoarthritis MRI Scoring System

Longitudinal Reliability Validated for OMERACT Thumb Base Osteoarthritis MRI Scoring System

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Researchers assessed the longitudinal reliability of the OMERACT thumb base osteoarthritis magnetic resonance imaging scoring system.

Comprehensive Care for Joint Replacement Model Cuts Costs

Comprehensive Care for Joint Replacement Model Cuts Costs

The Medicare-implemented Comprehensive Care for Joint Replacement bundled-payment model reduces spending for hip or knee replacement.

Effect Sizes Uncertain for Medication vs Placebo in Knee OA Pain

Effect Sizes Uncertain for Medication vs Placebo in Knee OA Pain

For patients with knee osteoarthritis and at least 12 months of follow-up, there is uncertainty around estimates of effect size for the change in pain in association with medications vs placebo.

Massage Offers Short-Term Relief of Knee Pain in Patients  With Arthritis

Massage Offers Short-Term Relief of Knee Pain in Patients With Arthritis

Weekly massage sessions may provide short-term symptom relief for patients with knee osteoarthritis, but the benefit is not maintained over 1 year of follow-up.

Several Factors Tied to Early Readmission After Hip Fracture Surgery

Several Factors Tied to Early Readmission After Hip Fracture Surgery

Several comorbidities are associated with an increased risk for early readmission after hip fracture surgery.

BMI May Mediate Inverse Link Between Fiber Intake, Knee OA

BMI May Mediate Inverse Link Between Fiber Intake, Knee OA

The inverse association between fiber intake and the risk for incident symptomatic knee osteoarthritis may be partially mediated by body mass index.

Ultrasound Effusion, Synovial Hypertrophy Thresholds Vary in Men vs Women With Knee OA

Ultrasound Effusion, Synovial Hypertrophy Thresholds Vary in Men vs Women With Knee OA

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Ultrasound effusion and synovial hypertrophy differ by gender in community-derived people without painful knee OA.

Radiographic Knee OA Not Correlated With Diabetes, Altered Glucose Metabolism

Radiographic Knee OA Not Correlated With Diabetes, Altered Glucose Metabolism

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Investigators examined whether there is a connection between diabetes and increased risk for knee osteoarthritis.

Elderly Patients Underrepresented in Clinical Trials for Rheumatoid Arthritis, Osteoarthritis

Elderly Patients Underrepresented in Clinical Trials for Rheumatoid Arthritis, Osteoarthritis

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Data show that the elderly are underrepresented in randomized clinical trials for rheumatoid arthritis and osteoarthritis.

One-Session Intervention for Hand OA Improved Grip Strength, Patient Satisfaction

One-Session Intervention for Hand OA Improved Grip Strength, Patient Satisfaction

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Investigators examined the effect of an interdisciplinary, combined intervention in patients with hand osteoarthritis.

Joint Mobilization Plus Exercise Beneficial for Knee Osteoarthritis

Joint Mobilization Plus Exercise Beneficial for Knee Osteoarthritis

Patellar mobilization therapy plus exercise has the potential to reduce pain and improve function and quality of life for patients with knee OA.

Higher Fibrosis Scores Associated With Lower Radiographic Severity in Knee OA

Higher Fibrosis Scores Associated With Lower Radiographic Severity in Knee OA

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Higher fibrosis scores were associated with lower radiographic disease severity over time in patients with knee osteoarthritis.

Knee Pain May Be Predictive of Structural Progression in Patients With OA

Knee Pain May Be Predictive of Structural Progression in Patients With OA

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Knee pain predicted accelerated cartilage volume loss and increased risk for incident radiographic osteoarthritis.

Pain Profiling May Predict Response to NSAID Plus Paracetamol in Knee Osteoarthritis

Pain Profiling May Predict Response to NSAID Plus Paracetamol in Knee Osteoarthritis

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Mechanistic pain profiling may help predict response to treatment for knee osteoarthritis with nonsteroidal anti-inflammatory drugs plus paracetamol.

FDA Fast Track Designation Granted for Investigational Osteoarthritis Treatment

FDA Fast Track Designation Granted for Investigational Osteoarthritis Treatment

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The FDA has granted Fast Track designation for GLPG1972/S201086 for the treatment of osteoarthritis.

Four Pain Susceptibility Phenotypes Identified in Knee Osteoarthritis

Four Pain Susceptibility Phenotypes Identified in Knee Osteoarthritis

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Four pain susceptibility phenotypes were identified in patients who had or were at risk for knee osteoarthritis, as well as risk factors for the development of persistent knee pain.

Moderate Physical Activity Slows Cartilage Loss in Women With Knee Osteoarthritis

Moderate Physical Activity Slows Cartilage Loss in Women With Knee Osteoarthritis

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Researchers examined the effect of physical activity on cartilage thickness loss in knee osteoarthritis.

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