Osteoarthritis

Performance Phenotypes of Lumbar Spinal Stenosis and OA With Accelerometry Data

Performance Phenotypes of Lumbar Spinal Stenosis and OA With Accelerometry Data

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The use of accelerometry data has led to the discovery of performance phenotypes of lumbar spinal stenosis and osteoarthritis.

Revision Rates for Arthritis-Related Hip Replacement Down

Revision Rates for Arthritis-Related Hip Replacement Down

Use of cross-linked polyethylene has significantly reduced the revision rate following total hip arthroplasty for osteoarthritis.

Knee Load Associated With Increased Walking Pain in Osteoarthritis

Knee Load Associated With Increased Walking Pain in Osteoarthritis

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Researchers examine the association between the knee adduction moment and increased knee pain during walking in patients with knee osteoarthritis.

Rates of Knee, Hip Arthroplasty Increasing Among Patients With Ankylosing Spondylitis

Rates of Knee, Hip Arthroplasty Increasing Among Patients With Ankylosing Spondylitis

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Researchers observed increased rates of both knee and hip arthroplasties in older patients with ankylosing spondylitis.

Antirheumatic Medication Management for Orthopedic Surgery: An Interdisciplinary Perspective

Antirheumatic Medication Management for Orthopedic Surgery: An Interdisciplinary Perspective

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A rheumatologist and orthopedic surgeon provide an interdisciplinary perspective on the perioperative management of antirheumatic medications in patients undergoing elective orthopedic surgery.

Knee Joint Hypermobility May Be Linked to OA Foot, Ankle Symptoms

Knee Joint Hypermobility May Be Linked to OA Foot, Ankle Symptoms

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Researchers examine the relationship of joint hypermobility with osteoarthritis and symptoms at the foot or ankle.

Higher PainDETECT Scores, Neuropathic Pain Preoperatively May Increase Risk for Chronic Pain Post-TKR

Higher PainDETECT Scores, Neuropathic Pain Preoperatively May Increase Risk for Chronic Pain Post-TKR

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Individuals with knee osteoarthritis who have indicators of high vs low/no levels of neuropathic pain may be at elevated risk for chronic pain after total knee replacement surgery.

Walking Disability Associated With Arterial Stiffness in Osteoarthritis

Walking Disability Associated With Arterial Stiffness in Osteoarthritis

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Six-minute walking distance was significantly associated with arterial stiffness in individuals with osteoarthritis.

Positive Phase 3 Results for Novel OA Pain Treatment Tanezumab

Positive Phase 3 Results for Novel OA Pain Treatment Tanezumab

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Pfizer and Lilly announced positive results from a study evaluating tanezumab, an investigational humanized monoclonal antibody, for the treatment of OA pain.

Neuropathic Symptoms Worsen Quality of Life, Function in Hip, Knee Osteoarthritis

Neuropathic Symptoms Worsen Quality of Life, Function in Hip, Knee Osteoarthritis

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Neuropathic-like symptoms may affect pain-related quality of life ratings and function in patients with hip and knee osteoarthritis, respectively.

Risk for Knee Osteoarthritis in Adolescent Men Predicted in Modified Nottingham Model

Risk for Knee Osteoarthritis in Adolescent Men Predicted in Modified Nottingham Model

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Diagnostic prediction modeling for knee osteoarthritis in adolescent men helps calculate the individual and population risk of developing knee osteoarthritis over 40 years.

Increased Physical Activity Improves Mobility After Joint Replacement in Older Women

Increased Physical Activity Improves Mobility After Joint Replacement in Older Women

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Women with osteoarthritis who reported lower physical activity levels before total joint replacement were more likely to experience mobility limitations in late life.

Statin Initiation Not Associated With Incident Hand Osteoarthritis

Statin Initiation Not Associated With Incident Hand Osteoarthritis

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Researchers observed no association between statin initiation and incident hand osteoarthritis.

Slower Walking Speed Linked to Increased BML in Accelerated Knee Osteoarthritis

Slower Walking Speed Linked to Increased BML in Accelerated Knee Osteoarthritis

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Changes in the 20-meter walking test were associated with worsening in bone marrow lesions and effusion volume in adults who developed accelerated knee OA.

Preterm Birth, Low Birth Weight Associated With Hip Osteoarthritis

Preterm Birth, Low Birth Weight Associated With Hip Osteoarthritis

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Preterm birth and low birth weight have been linked to hip bone shape abnormalities and hip osteoarthritis.

Expert Q&A: A Clinical Update on the Prevention, Treatment of Periprosthetic Joint Infections

Expert Q&A: A Clinical Update on the Prevention, Treatment of Periprosthetic Joint Infections

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Alberto V. Carli, MD, and Ashley E. Levack, MD, MAS, discuss preventive and treatment options for periprosthetic joint infections.

Greater Weight Loss Linked to Superior Outcomes in Knee OA

Greater Weight Loss Linked to Superior Outcomes in Knee OA

For overweight and obese older adults with knee osteoarthritis, greater weight loss is associated with superior clinical and mechanistic outcomes.

Sprifermin Improved Cartilage Morphology, Thickness in Knee Osteoarthritis

Sprifermin Improved Cartilage Morphology, Thickness in Knee Osteoarthritis

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Sprifermin has a positive effect on cartilage morphology and cartilage thickness in radiographic knee osteoarthritis.

Depressive Symptom Onset Linked to Disease Severity in Knee OA

Depressive Symptom Onset Linked to Disease Severity in Knee OA

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To effectively treat individuals with radiographic knee OA and comorbid depressive disorder, it is necessary to use a combined treatment strategy of 2 interventions delivered in parallel to simultaneously target each condition.

RA Associated With Greater Reduction in Short-Term Disease Burden vs Osteoarthritis

RA Associated With Greater Reduction in Short-Term Disease Burden vs Osteoarthritis

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Investigators analyzed MDHAQ/RAPID3 scores in patients with osteoarthritis or rheumatoid arthritis to assess disease burden associated with each rheumatic disease.

Zoledronic Acid May Not Improve Knee Osteoarthritis-Related Pain, Function Long-Term

Zoledronic Acid May Not Improve Knee Osteoarthritis-Related Pain, Function Long-Term

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Zoledronic acid did not significantly reduce knee pain or bone marrow lesion size overall in patients with knee osteoarthritis over 24 months.

NSAID Use Mediates CVD Risk in Osteoarthritis

NSAID Use Mediates CVD Risk in Osteoarthritis

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Nonsteroidal anti-inflammatory drug use mediated a substantial amount of cardiovascular disease risk in osteoarthritis.

BMI May Sufficiently Capture Knee OA Risk Associated With Increased Localized Adiposity

BMI May Sufficiently Capture Knee OA Risk Associated With Increased Localized Adiposity

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Researchers sought to determine whether central or peripheral adiposity measures are associated with incident radiographic knee osteoarthritis independent of BMI.

Hormonal, Reproductive Factors Associated With Knee Osteoarthritis in Women

Hormonal, Reproductive Factors Associated With Knee Osteoarthritis in Women

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Investigators sought to determine whether female reproductive and hormonal factors affect the incidence of total knee arthroplasty for osteoarthritis.

The Reliable Change Index: A Novel Approach to Estimate Osteoarthritis Progression

The Reliable Change Index: A Novel Approach to Estimate Osteoarthritis Progression

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The Reliable Change Index may be an effective method for identifying changes in joint space width in clinical and research settings.

Treatment for Prosthetic Joint Infections Gets FDA's QIDP Designation

Treatment for Prosthetic Joint Infections Gets FDA's QIDP Designation

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PJI is a challenging complication of joint arthroplasty with few effective treatment options.

New Combination Drug Approved to Treat Hypertension and OA Pain

New Combination Drug Approved to Treat Hypertension and OA Pain

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Consensi combines amlodipine besylate, a calcium-channel blocker, and celecoxib, a nonsteroidal anti-inflammatory drug.

Efficacy, Safety of OnabotulinumtoxinA Assessed for Knee OA Treatment

Efficacy, Safety of OnabotulinumtoxinA Assessed for Knee OA Treatment

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Investigators sought to evaluate intra-articular onabotulinumtoxinA 400 U and 200 U in reducing symptoms of knee OA in patients with nociceptive pain.

Patient-Reported Swelling vs MRI-Defined Effusion-Synovitis in OA With Meniscal Tear

Patient-Reported Swelling vs MRI-Defined Effusion-Synovitis in OA With Meniscal Tear

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Researchers sought to investigate the cross-sectional association between patient-reported swelling and effusion-synovitis on MRI in patients with OA and meniscal tear.

Late-Life Mobility Limitations Linked to Obesity After Arthroplasty for OA in Women

Late-Life Mobility Limitations Linked to Obesity After Arthroplasty for OA in Women

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Baseline obesity is associated with an increased risk for late-life mobility limitations in women undergoing joint replacement for OA.

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