Osteoarthritis

Radiographic Knee OA Not Correlated With Diabetes, Altered Glucose Metabolism

Radiographic Knee OA Not Correlated With Diabetes, Altered Glucose Metabolism

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Investigators examined whether there is a connection between diabetes and increased risk for knee osteoarthritis.

Elderly Patients Underrepresented in Clinical Trials for Rheumatoid Arthritis, Osteoarthritis

Elderly Patients Underrepresented in Clinical Trials for Rheumatoid Arthritis, Osteoarthritis

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Data show that the elderly are underrepresented in randomized clinical trials for rheumatoid arthritis and osteoarthritis.

One-Session Intervention for Hand OA Improved Grip Strength, Patient Satisfaction

One-Session Intervention for Hand OA Improved Grip Strength, Patient Satisfaction

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Investigators examined the effect of an interdisciplinary, combined intervention in patients with hand osteoarthritis.

Joint Mobilization Plus Exercise Beneficial for Knee Osteoarthritis

Joint Mobilization Plus Exercise Beneficial for Knee Osteoarthritis

Patellar mobilization therapy plus exercise has the potential to reduce pain and improve function and quality of life for patients with knee OA.

Higher Fibrosis Scores Associated With Lower Radiographic Severity in Knee OA

Higher Fibrosis Scores Associated With Lower Radiographic Severity in Knee OA

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Higher fibrosis scores were associated with lower radiographic disease severity over time in patients with knee osteoarthritis.

Knee Pain May Be Predictive of Structural Progression in Patients With OA

Knee Pain May Be Predictive of Structural Progression in Patients With OA

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Knee pain predicted accelerated cartilage volume loss and increased risk for incident radiographic osteoarthritis.

Pain Profiling May Predict Response to NSAID Plus Paracetamol in Knee Osteoarthritis

Pain Profiling May Predict Response to NSAID Plus Paracetamol in Knee Osteoarthritis

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Mechanistic pain profiling may help predict response to treatment for knee osteoarthritis with nonsteroidal anti-inflammatory drugs plus paracetamol.

FDA Fast Track Designation Granted for Investigational Osteoarthritis Treatment

FDA Fast Track Designation Granted for Investigational Osteoarthritis Treatment

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The FDA has granted Fast Track designation for GLPG1972/S201086 for the treatment of osteoarthritis.

Four Pain Susceptibility Phenotypes Identified in Knee Osteoarthritis

Four Pain Susceptibility Phenotypes Identified in Knee Osteoarthritis

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Four pain susceptibility phenotypes were identified in patients who had or were at risk for knee osteoarthritis, as well as risk factors for the development of persistent knee pain.

Moderate Physical Activity Slows Cartilage Loss in Women With Knee Osteoarthritis

Moderate Physical Activity Slows Cartilage Loss in Women With Knee Osteoarthritis

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Researchers examined the effect of physical activity on cartilage thickness loss in knee osteoarthritis.

Physician-Patient Discordance of Global Assessment Higher in Osteoarthritis vs Rheumatoid Arthritis

Physician-Patient Discordance of Global Assessment Higher in Osteoarthritis vs Rheumatoid Arthritis

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Researchers compared patient-physician discordance in global assessment in patients with osteoarthritis vs patients with rheumatoid arthritis seen in routine care.

No Benefit Found for Low-Dose Radiation Therapy for in Treatment of Knee Osteoarthritis

No Benefit Found for Low-Dose Radiation Therapy for in Treatment of Knee Osteoarthritis

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Data show that low-dose radiation therapy does not lead to a substantial reduction in symptoms in patients with knee OA compared with sham therapy.

CDC: About 1 in 3 Adults With Prediabetes Has Arthritis

CDC: About 1 in 3 Adults With Prediabetes Has Arthritis

About 1 in 3 adults with prediabetes has arthritis, and half of those with both conditions are physically inactive and/or obese.

Effects of Exercise Therapy on Molecular Biomarkers in Knee Osteoarthritis

Effects of Exercise Therapy on Molecular Biomarkers in Knee Osteoarthritis

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Exercise therapy does not increase the concentration of molecular biomarkers related to cartilage turnover and inflammation.

Prediction Models Developed to Predict Risk for Total Hip, Knee Replacements

Prediction Models Developed to Predict Risk for Total Hip, Knee Replacements

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Researchers developed two models to estimate an individual's risk for primary THR and TKR.

Childhood Maltreatment Associated With Arthritis in Adulthood

Childhood Maltreatment Associated With Arthritis in Adulthood

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Childhood maltreatment was associated with adulthood arthritis, particularly among those who experienced severe or frequent abuse.

Assessing Measurement Properties of Self-Report Physical Activity Instruments for Osteoarthritis

Assessing Measurement Properties of Self-Report Physical Activity Instruments for Osteoarthritis

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Researchers evaluated measurement properties of self-report physical activity instruments for patients with osteoarthritis.

Examining the Effects of Weight Loss in Patients With Knee OA, Obesity

Examining the Effects of Weight Loss in Patients With Knee OA, Obesity

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Weight loss in patients who are overweight or obese may improve symptoms through pathologic mechanisms in addition to reduction of joint burden.

High Bone Mineral Density Predicts Progression of Knee, Hip Osteoarthritis

High Bone Mineral Density Predicts Progression of Knee, Hip Osteoarthritis

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Researchers examined the longitudinal relationship between bone mineral density and the incidence and progression of knee, hip, and hand osteoarthritis.

Local Gentamicin Application Ineffective in Treatment of Periprosthetic Joint Infection

Local Gentamicin Application Ineffective in Treatment of Periprosthetic Joint Infection

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The use of gentamicin-impregnated beads and/or sponges should be discouraged in early acute periprosthetic joint infection as their use is associated with high failure rates.

Aspirin, Anticoagulants Similarly Prevent VTE After TKA

Aspirin, Anticoagulants Similarly Prevent VTE After TKA

Among patients undergoing TKA, aspirin alone may provide protection against postoperative VTE that is similar to that of other anticoagulants.

Prevalence of RA-Associated Autoantibodies Not Associated With Erosive Hand Osteoarthritis

Prevalence of RA-Associated Autoantibodies Not Associated With Erosive Hand Osteoarthritis

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The presence of 3 common rheumatoid arthritis-associated antibodies were not associated with erosive disease in patients with hand osteoarthritis.

Walking Each Day May Cut Risk for TKA Over 5 Years

Walking Each Day May Cut Risk for TKA Over 5 Years

For individuals with knee OA, replacing time not walking with walking at moderate-to-vigorous intensity is associated with reduced risk for TKA over 5 years.

 Novel, Intra-articular Wnt Pathway Inhibitor May Improve Knee Osteoarthritis

Novel, Intra-articular Wnt Pathway Inhibitor May Improve Knee Osteoarthritis

Yusuf Yazici, MD, discusses results from a trial evaluating a small molecule inhibitor of the Wnt pathway for the treatment of knee osteoarthritis.

Validating Clinical Risk Score of NSAID Toxicity in Osteoarthritis, RA

Validating Clinical Risk Score of NSAID Toxicity in Osteoarthritis, RA

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Data from the PRECISION trial were used to develop and validate a clinical risk score for NSAID toxicity in OA and RA.

Physical Therapy, Surgery Provide Similar Pain Relief After Meniscal Tear With OA

Physical Therapy, Surgery Provide Similar Pain Relief After Meniscal Tear With OA

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Patients generally experienced pain relief over 5 years regardless of whether they received physical therapy or arthroscopic partial menisectomy.

Metabolic Syndrome May Be Associated With Radiographic Knee Osteoarthritic-Related Pain

Metabolic Syndrome May Be Associated With Radiographic Knee Osteoarthritic-Related Pain

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Metabolic syndrome, and specifically the component of abdominal obesity, may be associated with pain intensity and number of painful sites in adults with radiographic knee osteoarthritis.

Osteoarthritis Prevention: Important Considerations for Population-Based Strategies

Osteoarthritis Prevention: Important Considerations for Population-Based Strategies

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David T. Felson, MD, MPH, and Jos Runhaar, PhD, reflect on important population-based osteoarthritis prevention strategies and knowledge gaps that still exist in this field.

Differentiation of Knee Pain Phenotypes Among Older Adults

Differentiation of Knee Pain Phenotypes Among Older Adults

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A population-based, cohort study was conducted to identify knee pain in a group of older adults.

Knee Effusion Volume Predicts Osteoarthritis Progression and Knee Replacement

Knee Effusion Volume Predicts Osteoarthritis Progression and Knee Replacement

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Investigators sought to determine if change in knee effusion volume from baseline to 1 year was predictive of cartilage volume loss and osteoarthritis progression in individuals at risk for osteoarthritis of the knee.

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