Osteoporosis

Fifteen Genetic Determinants of Fracture Identified

Fifteen Genetic Determinants of Fracture Identified

Fifteen genetic determinants of fracture, which are also associated with bone mineral density, have been identified.

Advanced Glycation End Products and esRAGE Predict Hip Fractures in Older Men

Advanced Glycation End Products and esRAGE Predict Hip Fractures in Older Men

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Investigators assess whether circulating advanced glycation end products and esRAGE were associated with bone turnover and risk for fracture.

Poststroke Statin Therapy Associated With Lower Risk for Osteoporosis, Fractures

Poststroke Statin Therapy Associated With Lower Risk for Osteoporosis, Fractures

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A variety of underlying mechanisms may be attributed to the role of statins in preventing bone-related disorders.

Lower Postoperative Mortality With Hip Fracture Surgery on Day of Admission

Lower Postoperative Mortality With Hip Fracture Surgery on Day of Admission

Postoperative mortality is lower for medically stable older patients who undergo surgery for hip fracture on the day of admission or the following day.

Influence of Weight Loss, Resistance Training, and Aerobic Training on Bone Health

Influence of Weight Loss, Resistance Training, and Aerobic Training on Bone Health

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Investigators assessed the effect of exercise modality during dietary-induced on bone health.

Sedation Level After Hip Fracture Repair May Not Affect Delirium Risk

Sedation Level After Hip Fracture Repair May Not Affect Delirium Risk

For older patients undergoing hip fracture repair, the level of sedation does not affect delirium risk overall.

Real-World Data Show Reduced Fracture Rates in Teriparatide-Treated Osteoporosis

Real-World Data Show Reduced Fracture Rates in Teriparatide-Treated Osteoporosis

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Rates of incident clinical vertebral fracture, incident nonvertebral fracture, hip fracture, and clinical fractures decreased 6 months after initiation of teriparatide.

Genetic Screening May Predict Osteoporosis and Fracture Risk

Genetic Screening May Predict Osteoporosis and Fracture Risk

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Genetic testing may identify individuals with an increased risk for osteoporosis and bone fracture.

One-Third of Canadian Patients Get Hip Fracture Repair Within 24 Hours

One-Third of Canadian Patients Get Hip Fracture Repair Within 24 Hours

Only one-third of Canadian patients received hip fracture repair surgery within the desired 24 hours.

HbA1c-Corrected FRAX Score May Better Predict Fracture Risk in Type 2 Diabetes

HbA1c-Corrected FRAX Score May Better Predict Fracture Risk in Type 2 Diabetes

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A corrected HbA1c factor may improve the ability to predict the risk for fracture by the FRAX algorithm in T2D.

Decreased Osteoporosis Treatment Initiation Observed After Hip Fracture

Decreased Osteoporosis Treatment Initiation Observed After Hip Fracture

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Researchers observed a reduction in subsequent nonvertebral fracture rates in patients who initiated osteoporosis treatment.

Effect of Mediterranean Diet Plus Vitamin D3 on Bone Density in Osteoporosis

Effect of Mediterranean Diet Plus Vitamin D3 on Bone Density in Osteoporosis

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Investigators examined the effect of consuming a Mediterranean-style diet for 1 year on inflammatory response and bone health in the elderly.

Empagliflozin Does Not Increase Fracture Risk in Type 2 Diabetes

Empagliflozin Does Not Increase Fracture Risk in Type 2 Diabetes

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The risk for bone fractures was not increased in patients with type 2 diabetes using empagliflozin compared with placebo or glimepiride.

New Romosozumab BLA Includes Data From Additional Osteoporosis Trials

New Romosozumab BLA Includes Data From Additional Osteoporosis Trials

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The Biologics License Application has been resubmitted for Evenity, an investigational treatment for osteoporosis in postmenopausal women at high risk for fracture.

Romosozumab: Effective in Men With Osteoporosis

Romosozumab: Effective in Men With Osteoporosis

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Romosozumab increased spine and hip bone mineral density after 12 months of treatment.

Treating Osteoporotic Pain: Expert Interview

Treating Osteoporotic Pain: Expert Interview

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Pain resulting from osteoporotic fractures should be treated with a multimodal approach that includes pharmacological and nonpharmacological strategies.

Osteoporosis Fracture Risk Awareness Lacking in Postmenopausal Women

Osteoporosis Fracture Risk Awareness Lacking in Postmenopausal Women

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Postmenopausal women have little awareness of osteoporotic fracture risk and poor understanding that a fragility fracture may be indicative of osteoporosis and that it increases future fracture risk.

USPSTF Favors Osteoporosis Screening to Prevent Fracture

USPSTF Favors Osteoporosis Screening to Prevent Fracture

Screening is recommended for women aged ≥65 years and younger women who have been through menopause and are at increased risk for osteoporosis.

Alendronate May Reduce Risk for CV Events After Hip Fracture

Alendronate May Reduce Risk for CV Events After Hip Fracture

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Use of alendronate in individuals who experience a hip fracture is associated with a reduced risk for cardiovascular mortality, myocardial infarction, and stroke.

Serotonin Levels Predict Increased Risk for Hip Fracture, Nonvertebral Osteoporotic Fracture

Serotonin Levels Predict Increased Risk for Hip Fracture, Nonvertebral Osteoporotic Fracture

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High levels of serotonin are predictive of an increased risk for hip fracture, nonvertebral osteoporotic fracture, and incident fractures in older men.

Romosozumab Followed by Denosumab Effective for BMD Increase in Postmenopausal Women

Romosozumab Followed by Denosumab Effective for BMD Increase in Postmenopausal Women

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Romosozumab increased bone mineral density in postmenopausal women through increased bone formation and decreased bone resorption.

Higher Groin <I>C Avidum</I> Colonization in Obese Patients After Hip Arthroplasty

Higher Groin C Avidum Colonization in Obese Patients After Hip Arthroplasty

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Researchers assessed the incidence of Cutibacterium avidum infection in patients following primary hip arthroplasty.

Examining Bone Microarchitecture, Strength in Older Men With Accelerated Bone Loss

Examining Bone Microarchitecture, Strength in Older Men With Accelerated Bone Loss

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Men with accelerated bone loss have lower estimated bone strength, poorer trabecular microarchitecture, and thinner cortices compared with men without accelerated bone loss.

Associations Between Site-Specific BMD, Anthropometric, Glucose Homeostasis Traits

Associations Between Site-Specific BMD, Anthropometric, Glucose Homeostasis Traits

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Negative effects of 2-hour glucose was pronounced at the cortical-bone-dominant sites in women.

Prolia Approved for Glucocorticoid-Induced Osteoporosis

Prolia Approved for Glucocorticoid-Induced Osteoporosis

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The FDA has approved use of Prolia for the treatment of glucocorticoid-induced osteoporosis in men and women at high risk for fracture.

Effects of the 2 Types of Anorexia Nervosa on Bone Metabolism

Effects of the 2 Types of Anorexia Nervosa on Bone Metabolism

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Investigators sought to determine whether both restrictive and purging types of anorexia nervosa effect bone metabolism.

Adverse Effect of Osteoporosis Drug May Help Treat Hair Loss

Adverse Effect of Osteoporosis Drug May Help Treat Hair Loss

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An osteoporosis treatment may have a positive effect on human hair follicles from those undergoing hair transplantation surgery.

Osteoporosis Drug Shows Cardioprotective Potential at 10-Year Follow-Up

Osteoporosis Drug Shows Cardioprotective Potential at 10-Year Follow-Up

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The 1-year cardiovascular mortality hazard ratio (HR) for alendronate users was 0.33 (95% CI, 0.17 to 0.65) and 0.55 for incident myocardial infarction (95% CI, 0.34 to 0.89).

Subclinical Thyroid Dysfunction Not Associated With Hip Fracture Risk in Older Men

Subclinical Thyroid Dysfunction Not Associated With Hip Fracture Risk in Older Men

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Findings do not support a role for subclinical thyroid dysfunction as a biomarker for bone-related outcomes in older men.

Good Glycemic Control May Influence Bone Metabolism in Type 2 Diabetes

Good Glycemic Control May Influence Bone Metabolism in Type 2 Diabetes

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Researchers showed that improved glycemic control is associated with higher bone resorption, possibly reflecting normalization rather than an abnormal increase in bone resorption.

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