Osteoporosis

Denosumab Reduces Bone Turnover by Inhibiting Osteoclast Formation, Activity in Cortical Bone

Denosumab Reduces Bone Turnover by Inhibiting Osteoclast Formation, Activity in Cortical Bone

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Denosumab inhibits osteoclast formation and activity in cortical bone, and this mechanism of action may be reflected by the reduction of erosion in both depth and surface.

Comparing Osteoporosis Screening, Treatment Strategies in Postmenopausal Women

Comparing Osteoporosis Screening, Treatment Strategies in Postmenopausal Women

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The need for effective osteoporosis screening tools and treatment strategies is high, as the current methods have a low sensitivity for determining postmenopausal women at risk for a major osteoporotic fracture.

Antidepressant Use in Seniors Linked to Risk for Hip Fracture

Antidepressant Use in Seniors Linked to Risk for Hip Fracture

Among older adults, antidepressant users sustain more hip fractures than nonusers both before and after therapy initiation.

Primary Hypertension May Not Affect Prognosis of Postmenopausal Osteoporosis

Primary Hypertension May Not Affect Prognosis of Postmenopausal Osteoporosis

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The presence of primary hypertension does not appear to have an effect on the prognosis of postmenopausal osteoporosis.

Managing Bisphosphonate Drug Holidays in Patients With Osteoporosis

Managing Bisphosphonate Drug Holidays in Patients With Osteoporosis

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Ongoing treatment with bisphosphonate therapy may not be needed to prevent future fractures in certain patients due to the sustained effect of the drug.

Young Breast Cancer Patients Face Higher Risk for Osteoporosis

Young Breast Cancer Patients Face Higher Risk for Osteoporosis

The risk for bone loss rose sharply in young patients with breast cancer who received standard treatment.

Poor Vitamin K Status Linked to Low BMD, Increased Fracture Risk in ESRD

Poor Vitamin K Status Linked to Low BMD, Increased Fracture Risk in ESRD

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Poor vitamin K status is associated with inflammation and low areal bone mineral density (BMD) among patients with end-stage renal disease.

Impact Microindentation May Not Predict Atypical Fracture Risk

Impact Microindentation May Not Predict Atypical Fracture Risk

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Can a common measurement of bone material strength predict future breaks in postmenopausal women with recent atypical fractures?

Bone Indices on CT Scan Predict Fracture Risk in Older Adults

Bone Indices on CT Scan Predict Fracture Risk in Older Adults

HR-pQCT indices improve prediction of fracture beyond bone mineral density and FRAX scores in older adults.

Statin Use May Improve Bone Microstructure in Women With Osteoporosis

Statin Use May Improve Bone Microstructure in Women With Osteoporosis

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Statin use is associated with better cortical bone characteristics in older women with osteoporosis, but results are dependent upon the potency of the statins.

Lateral Spine Imaging for Vertebral Fractures May Improve Osteoporosis Detection

Lateral Spine Imaging for Vertebral Fractures May Improve Osteoporosis Detection

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The use of lateral spine imaging to detect asymptomatic vertebral fractures in older women may improve osteoporosis identification.

Denosumab Promising for TDT-Induced Osteoporosis Treatment

Denosumab Promising for TDT-Induced Osteoporosis Treatment

Denosumab may be beneficial for managing transfusion-dependent thalassemia-induced osteoporosis.

An Intermediary Role for Insulin Resistance in the Adipose-Bone Mass Relationship in Adolescents

An Intermediary Role for Insulin Resistance in the Adipose-Bone Mass Relationship in Adolescents

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Insulin resistance may play an intermediary role in the relationship between adiposity and lumbar spine bone mass in adolescents.

High Bone Mineral Density Predicts Progression of Knee, Hip Osteoarthritis

High Bone Mineral Density Predicts Progression of Knee, Hip Osteoarthritis

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Researchers examined the longitudinal relationship between bone mineral density and the incidence and progression of knee, hip, and hand osteoarthritis.

Vitamin D Supplementation Has No Effect on Musculoskeletal Health

Vitamin D Supplementation Has No Effect on Musculoskeletal Health

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There is little justification for the use of vitamin D supplements to maintain or improve musculoskeletal health.

RAAS Inhibitors Do Not Increase Fracture Risk, Osteoporosis in Postmenopausal Women

RAAS Inhibitors Do Not Increase Fracture Risk, Osteoporosis in Postmenopausal Women

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RAAS inhibitors do not have a deleterious effect on skeletal health in postmenopausal women.

Zoledronate Lowers Fracture Risk in Women With Osteopenia

Zoledronate Lowers Fracture Risk in Women With Osteopenia

The risk for fragility fractures is significantly lower in women with osteopenia who receive zoledronate than in those who receive placebo.

Diabetes Associated With Elevated Risk for Arthritis, Osteoporosis

Diabetes Associated With Elevated Risk for Arthritis, Osteoporosis

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Osteoarthritis was the most common form of arthritis in patients with diabetes but rheumatoid arthritis had the most pronounced association with diabetes.

Bone Mineral Density Improved With Intravenous Ibandronate in Osteoporosis

Bone Mineral Density Improved With Intravenous Ibandronate in Osteoporosis

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Investigators assessed the effectiveness of intravenous ibandronate on bone mineral density in patients with osteoporosis who did not respond to oral bisphosphonates.

Drug Holidays May Reduce Risk for Atypical Femur Fracture

Drug Holidays May Reduce Risk for Atypical Femur Fracture

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Bisphosphonate holidays of 3 to 5 years have been recommended as a means of achieving the antifracture benefit of the medication.

Effects of Vitamin D3 Treatment on Bone Strength in Postmenopausal Women

Effects of Vitamin D3 Treatment on Bone Strength in Postmenopausal Women

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Investigators sought to determine the effects of vitamin D3 supplementation in postmenopausal women with low serum 25(OH)D and high parathyroid hormone levels.

Early Life Exposures Affect Bone Density in Young Adulthood

Early Life Exposures Affect Bone Density in Young Adulthood

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Early life exposures, such as maternal smoking and breastfeeding, may have effects on bone mineral density in young adulthood.

Bone Mineral Density Changes After Anastrozole in Postmenopausal Women

Bone Mineral Density Changes After Anastrozole in Postmenopausal Women

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In postmenopausal women who were randomly assigned anastrozole, bone mineral density showed significant improvement at the lumbar spine.

Glucocorticoids Linked to Significant Bone Deficit in Pediatric Crohn Disease

Glucocorticoids Linked to Significant Bone Deficit in Pediatric Crohn Disease

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Glucocorticoid therapy was linked to significant bone deficits across multiple axial sites, regardless of disease activity.

MicroRNAs Linked to Increased Cortical Bone Porosity in Postmenopausal Women With History of Fracture

MicroRNAs Linked to Increased Cortical Bone Porosity in Postmenopausal Women With History of Fracture

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Findings suggest potential pathomechanistic links between miRNAs and cortical porosity. .

Effects of Concurrent Osteoarthritis, Osteoporosis on Bone Quality in Postmenopausal Women

Effects of Concurrent Osteoarthritis, Osteoporosis on Bone Quality in Postmenopausal Women

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Researchers sought to determine the differences in muscle and bone quality in postmenopausal women with osteoporosis, osteoarthritis, or both.

Consensus-Based Recommendations Released to Improve Osteoporosis Diagnosis, Treatment

Consensus-Based Recommendations Released to Improve Osteoporosis Diagnosis, Treatment

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The ASBMR Secondary Fracture Prevention Initiative Coalition outlined recommendations to improve efforts to increase diagnosis and treatment of individuals who are at high risk for osteoporosis.

Risk for Subsequent Osteoporotic Fracture Elevated in Men vs Women

Risk for Subsequent Osteoporotic Fracture Elevated in Men vs Women

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The risk for subsequent osteoporotic fracture was elevated for both sexes over a 25-year follow-up period.

Fifteen Genetic Determinants of Fracture Identified

Fifteen Genetic Determinants of Fracture Identified

Fifteen genetic determinants of fracture, which are also associated with bone mineral density, have been identified.

Advanced Glycation End Products and esRAGE Predict Hip Fractures in Older Men

Advanced Glycation End Products and esRAGE Predict Hip Fractures in Older Men

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Investigators assess whether circulating advanced glycation end products and esRAGE were associated with bone turnover and risk for fracture.

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